Aqueous Pistacia lentiscus Leaves Extract Protects Against Ethanol-Induced Gastroduodenal Ulcers in Rat DOI

Yasmina Zahouani,

Abdelhafidh Khazri,

Samir Touaylia

et al.

Biomarkers, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: May 5, 2025

The protective effects of aqueous extract Pistacia lentiscus leaves (AELPL) against gastric and duodenal ulcers induced by alcohol oral gavage administration in Wistar rats were investigated this study. divided into six groups control, ethanol single, + AEPL (25-50-100) famotidine ethanol. HPLC-MS analysis allowed the identification numerous phenolic compounds P. such as flavonoids (isoquercetin luteolin), flavonols (catechin, rutin kaempferol), acids (ellagic dicaffeoylquinic) tannins. Ethanol significant ulcerative lesions, while AELPL pretreatment (25, 50 100 mg/kg) provided a dose-dependent mucosal protection comparable to famotidine, widely used drug for treatment ulcers. like also restored pH volume, counteracting ethanol-induced acidity. Biochemical analyses demonstrated that mitigated oxidative stress reducing lipid peroxidation, carbonylated proteins hydrogen peroxide levels, whereas it non-protein thiols content stomach, duodenum plasma manner. Additionally, antioxidant enzyme activities including catalase, superoxide dismutase, glutathione peroxidase glutathione-S-transferase. reduced increase free iron, ionized calcium interleukin-6 indicating its anti-inflammatory potential. These findings suggest exhibits gastroduodenal damage, with efficacy famotidine. Protective mechanisms likely involve modulation inflammation, supporting AELPL's potential therapeutic agent injuries.

Language: Английский

Beyond the Nut: Pistacia Leaves as Natural Food Preservatives DOI Creative Commons
Daniela Batovska, Moshe Inbar

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3138 - 3138

Published: Sept. 30, 2024

The pistachio tree (Pistacia vera) is globally renowned for its nutritious nuts, while leaves remain an underutilized source of chemicals with significant potential value as food preservatives. Similar may be found in the other wild Pistacia species common Central Asia, Levant, and around Mediterranean. Some species’ have been used natural preservatives, demonstrating their effectiveness highlighting rich bioactive components. This review investigates antioxidant antimicrobial properties leaves, comparing both cultivated species. A comprehensive search was performed across several scientific databases, including PubMed, Scopus, Web Science, Google Scholar, utilizing a combination keywords related to compounds. inclusion criteria focused on articles published English from 2017 till end June 2024, analyzing activities employing relevant extraction methods. total 71 literature sources were included, covering such P. vera, atlantica, terebinthus, others sourced countries Iran, Turkey, Italy. that are polyphenolic compounds exhibit robust properties, certain outperforming suggesting species-specific traits enhance preservative potential. major findings indicate extracts superior bioactivity, which could harnessed preservation. These insights underscore promising role further research needed address challenges application. Exploring synergistic effects preservatives lead innovative solutions preservation fostering local economic growth.

Language: Английский

Citations

3
Chemical Analysis and Antioxidant Activities of Resin Fractions from Pistacia lentiscus L. var. Chia in Neuroblastoma SH-SY5Y Cells DOI Creative Commons

Achilleas Georgantopoulos,

Foteini D. Kalousi,

Federica Pollastro

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 997 - 997

Published: Feb. 21, 2025

Chios mastiha is the natural aromatic resin of Pistacia lentiscus L. var. Chia, Anacardiaceae, which exclusively cultivated in southern part Greek island Chios. (P. lenticonus/Chios mastiha) well-known for its distinctive taste and aroma has been known since ancient times due to healing properties gastrointestinal inflammatory disorders because anti-bacterial anti-fungal activities. In this study, chemical composition, applying LC-QTOF-MS/MS analysis, antioxidant activities three different polarity P. fractions, apolar, medium polar, were characterized human neuroblastoma SH-SY5Y cells. Chemical analysis fractions unveiled new components mastiha, mainly fatty acids compounds, their activity regulatory effects on lipid metabolism. By MTT assay confocal microscopy we showed that especially apolar polar enriched triterpenes acids, caused suppression H2O2-induced reduction cell viability, ROS production, depolarization mitochondrial membrane potential, Moreover, Western blot revealed fraction, induced expression PPARα, crucial role Induction a GR target gene, was also accompanied by an increase protein levels. Enhanced fraction may be correlated with triterpenoids. Thus, our results indicate neuroprotective actions highlighting potential application as agents neurodegenerative diseases.

Language: Английский

Citations

0
Comprehensive assessment of antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts from Pistacia lentiscus L. leaves: a potential natural source for managing oxidative stress and diabetes-related complications DOI Creative Commons
Hasnae El Allaoui, Khadija Haboubi,

Kawthar El Ahmadi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

This study evaluates the phenolic and flavonoid contents, as well antioxidant, antidiabetic, anti-glycation properties of aqueous methanolic extracts from Pistacia lentiscus L. leaves. The antioxidant activity was assessed using DPPH, ABTS, FRAP, iron-chelation assays, revealing superior in extract. Both exhibited potent antidiabetic effects by inhibiting digestive enzyme alpha-amylase, with IC50 values 2,291 ± 0.002 μg/mL (aqueous) 2,889 (methanolic). Additionally, demonstrated significant activity, reducing advanced glycation end-product (AGE) formation, fructosamine levels, protecting thiol groups, extract providing greater protection. These findings underscore potential P. a natural source bioactive compounds for managing oxidative stress diabetes-related complications.

Language: Английский

Citations

0
The Moroccan Meska Horra: A Natural Candidate for Food and Therapeutic Applications DOI Creative Commons
Abdessamad Beraich, Burak Dikici, Hammadi El Farissi

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1158 - 1158

Published: March 26, 2025

Mastic gum (Pistacia lentiscus L. resin), traditionally known as Meska Horra in Morocco, is valued for its bioactive properties, although composition varies depending on geographical origin. The essential oil profile also influenced by the extraction method used. This study evaluates chemical composition, bioactivity, and efficiency of from eastern Morocco. Specifically, it explores potential a natural preservative functional food ingredient comparing various methods their impact profiles volatile compounds. obtained through hydrodistillation yielded 1.4% met standards European Pharmacopoeia despite differing quantity Chios mastic gum. major constituents were α-pinene, β-pinene, D-limonene, comprising 55% oil. demonstrated significant antioxidant antimicrobial activity, supporting application preservation. Molecular docking indicated that caryophyllene oxide are key compounds, effectiveness may be enhanced synergistic interactions. Comparative analysis showed headspace (HS) captured highly monoterpenes, while solid-phase microextraction (SPME) ultrasound-assisted SPME (US-SPME) more effective at extracting compounds such cis-ocimene limonene. US-SPME extracted higher levels m-cymene but lower α-pinene. These findings highlights importance optimizing further investigating role effects foods pharmaceutical applications.

Language: Английский

Citations

0
Optimization of bacterial inhibition by Pistacia lentiscus essential oils using experimental design methodology DOI
Sarra Bachkouel, Mariem Ben Jemaa, Soumaya Bourgou

et al.

Euro-Mediterranean Journal for Environmental Integration, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Aqueous Pistacia lentiscus Leaves Extract Protects Against Ethanol-Induced Gastroduodenal Ulcers in Rat DOI

Yasmina Zahouani,

Abdelhafidh Khazri,

Samir Touaylia

et al.

Biomarkers, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: May 5, 2025

The protective effects of aqueous extract Pistacia lentiscus leaves (AELPL) against gastric and duodenal ulcers induced by alcohol oral gavage administration in Wistar rats were investigated this study. divided into six groups control, ethanol single, + AEPL (25-50-100) famotidine ethanol. HPLC-MS analysis allowed the identification numerous phenolic compounds P. such as flavonoids (isoquercetin luteolin), flavonols (catechin, rutin kaempferol), acids (ellagic dicaffeoylquinic) tannins. Ethanol significant ulcerative lesions, while AELPL pretreatment (25, 50 100 mg/kg) provided a dose-dependent mucosal protection comparable to famotidine, widely used drug for treatment ulcers. like also restored pH volume, counteracting ethanol-induced acidity. Biochemical analyses demonstrated that mitigated oxidative stress reducing lipid peroxidation, carbonylated proteins hydrogen peroxide levels, whereas it non-protein thiols content stomach, duodenum plasma manner. Additionally, antioxidant enzyme activities including catalase, superoxide dismutase, glutathione peroxidase glutathione-S-transferase. reduced increase free iron, ionized calcium interleukin-6 indicating its anti-inflammatory potential. These findings suggest exhibits gastroduodenal damage, with efficacy famotidine. Protective mechanisms likely involve modulation inflammation, supporting AELPL's potential therapeutic agent injuries.

Language: Английский

Citations

0