Microbiota modifications in prehabilitation – the next step towards comprehensive preparation for surgery. The scoping review DOI Open Access

Igor Łoniewski,

Tomasz Banasiewicz,

Jerzy Sieńko

et al.

Gastroenterology Review, Journal Year: 2024, Volume and Issue: 19(4), P. 347 - 361

Published: Jan. 1, 2024

This scoping review highlights the role of microbiota modifications in prehabilitation for surgical patients. It emphasises importance optimising gut through probiotics, synbiotics, and postbiotics to reduce complications, such as site infections (SSIs). The that dysbiosis, worsened by surgery, stress, antibiotics, poor diet, can lead increased infection risk slower recovery. Evidence from systematic reviews, meta-analyses, randomised controlled trials suggests microbiota-targeted interventions SSIs, enhance immune responses, promote quicker advocates an individualised approach prehabilitation, incorporating based on patient-specific factors surgery type. However, it also notes need further research standardise therapeutic regimens confirm safety efficacy these clinical practice.

Language: Английский

Fecal Microbiota Characteristics in Constipation-Predominant and Mixed-Type Irritable Bowel Syndrome DOI Creative Commons
Mariya Gryaznova, Yuliya Smirnova, Inna Burakova

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1414 - 1414

Published: July 12, 2024

Irritable bowel syndrome (IBS) is a common condition that affects the lifestyle of patients. It associated with significant changes in composition gut microbiome, but underlying microbial mechanisms remain to be fully understood. We study fecal microbiome patients constipation-predominant IBS (IBS-C) and mixed-type (IBS-M).

Language: Английский

Citations

9
Function and therapeutic potential of Amuc_1100, an outer membrane protein of Akkermansia muciniphila: A review DOI
Xuhui Wu, Dahai Yu, Yixuan Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142442 - 142442

Published: March 1, 2025

Language: Английский

Citations

0
The Impact of Diet on the Colonization of Beneficial Microbes from an Ecological Perspective DOI
Zelin Chen,

Chuntao Xiao,

Jintun Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

With growing recognition of the pivotal role gut microbiota in human health, probiotics have gained widespread attention for their potential to restore microbial homeostasis. However, a critical challenge persists: limited colonization efficiency among most probiotic strains compromises therapeutic efficacy. This overview synthesizes ecological principles with cutting-edge microbiome research elucidate dynamic interplay between dietary components and within intestinal niche. systematically analyzes: (1) stage-specific mechanisms spanning introduction, establishment, proliferation; (2) nutrient-driven modulation composition function; (3) dual common patterns as both facilitators disruptors persistence. Notably, this identifies key strategies, including precision delivery prebiotic fibers polyphenol-microbiota crosstalk, that enhance niche adaptation through pH optimization, adhesion potentiation, competitive exclusion pathogens. Furthermore, critically evaluates current limitations research, particularly strain-specific variability methodological constraints simulating host-microbe-diet tripartite interactions. To bridge these gaps, proposes an interdisciplinary framework integrating omics-driven strain selection, engineered systems, personalized nutrition models. Collectively, work advances mechanistic understanding diet-microbiota interactions while providing actionable insights developing targeted therapies evidence-based interventions optimize ecosystem resilience.

Language: Английский

Citations

0
Broad-Spectrum Antibacterial Activity of Antioxidant Octyl Gallate and Its Impact on Gut Microbiome DOI Creative Commons

Junshu Yang,

Trevor J. Gould, Byeonghwa Jeon

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 731 - 731

Published: Aug. 4, 2024

In this study, we investigated the antibacterial activity of octyl gallate (OG), an antioxidant food additive, against both Gram-positive and Gram-negative bacterial pathogens. OG demonstrated robust bactericidal pathogens with minimum inhibitory concentrations (MIC) 4 to 8 µg/mL (MBC) 16 in vitro. However, exhibited limited bacteria, including

Language: Английский

Citations

3
Akkermansia muciniphila helps in the recovery of lipopolysaccharide-fed mice with mild intestinal dysfunction DOI Creative Commons
Yue Hu,

Jun Zhou,

Xiaoqi Lin

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Background Mild intestinal dysfunction, linked to subtle yet significant health issues, can be induced by lipopolysaccharide (LPS), a Gram-negative bacterial component that disrupts gut function and triggers inflammation. Akkermansia muciniphila has shown promise as probiotic for due its roles in mucin degradation short-chain fatty acid production. This study explores the therapeutic effects of on LPS-induced mild dysfunction mice. Methods Thirty-eight 6-week-old C57BL/6 mice were split into control ( n = 19) LPS-treated groups. received 300 μg/kg/day LPS 4 weeks, followed supplementation at 41 mg/kg/day (Akk1) or 82 (Akk2) another weeks. Gut microbiota was analyzed via metagenomic sequencing, gene expression evaluated through transcriptomics. Results significantly altered microbiota, reducing diversity increasing pathogenic genera like Lachnoclostridium. supplementation, particularly higher doses, partially restored beneficial such Muribaculum. Transcriptomics showed immune inflammatory responses, while reduced these modulating pathways TNF NF-kappa B signaling. Conclusion mitigates restoring balance highlighting potential agent health.

Language: Английский

Citations

0
Gut-Vascular Axis and Postbiotics: The Need for Clear Definitions and Further Research DOI Creative Commons
Karolina Skonieczna‐Żydecka, Igor Łoniewski, Mariusz Kaczmarczyk

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107405 - 107405

Published: Sept. 11, 2024

Language: Английский

Citations

0
Studies on the Probiotic, Adhesion, and Induction Properties of Artisanal Lactic Acid Bacteria: to Customize a Gastrointestinal Niche to Trigger Anti-obesity Functions DOI
Aslıhan KAMBER, Çisem Bulut Albayrak,

H S Harsa

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Language: Английский

Citations

0
Akkermansia muciniphila- and Pathogenic Bacteria-Derived Endotoxins Differently Regulate Human Dendritic Cell Generation and γδ T Lymphocyte Activation DOI Creative Commons

Veronica Fertitta,

Barbara Varano, Manuela Del Cornò

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1571 - 1571

Published: Dec. 9, 2024

Lipopolysaccharide (LPS) is a potent endotoxin released at high concentrations in acute infections, causing massive host inflammatory response. Accumulating evidence indicates that dysbiosis-associated chronic low levels of circulating LPS can sustain prolonged sterile low-grade inflammation increases the risk several non-communicable diseases. Interventions aimed increasing abundance beneficial/probiotic bacteria, including Akkermansia muciniphila, result reduced inflammation, favoring metabolic and immune health. Immunosuppression common feature conditions dendritic cells (DCs) represent key targets given their ability to shift balance toward immunity or tolerance. In this study, effects from pathogenic (Escherichia coli Salmonella enterica) probiotic (Akkermansia muciniphila) bacterial species on human DC generation functions were compared. We report monocyte precursor priming with Escherichia enterica forces differentiation PD-L1-expressing DCs, releasing IL-6 IL-10, impairs capacity drive full TCR-Vδ2 T cell activation. Conversely, comparable muciniphila promoted DCs preserved activating potential immunostimulatory properties. These results shed light mechanisms underlying impact endotoxemia disease pathogenesis, increase our understanding immunomodulatory muciniphila.

Language: Английский

Citations

0
Microbiota modifications in prehabilitation – the next step towards comprehensive preparation for surgery. The scoping review DOI Open Access

Igor Łoniewski,

Tomasz Banasiewicz,

Jerzy Sieńko

et al.

Gastroenterology Review, Journal Year: 2024, Volume and Issue: 19(4), P. 347 - 361

Published: Jan. 1, 2024

This scoping review highlights the role of microbiota modifications in prehabilitation for surgical patients. It emphasises importance optimising gut through probiotics, synbiotics, and postbiotics to reduce complications, such as site infections (SSIs). The that dysbiosis, worsened by surgery, stress, antibiotics, poor diet, can lead increased infection risk slower recovery. Evidence from systematic reviews, meta-analyses, randomised controlled trials suggests microbiota-targeted interventions SSIs, enhance immune responses, promote quicker advocates an individualised approach prehabilitation, incorporating based on patient-specific factors surgery type. However, it also notes need further research standardise therapeutic regimens confirm safety efficacy these clinical practice.

Language: Английский

Citations

0