Erosive tooth wear, dental decay, and periodontal health in obese and normal weight children and adolescents DOI Open Access
Aslı Soğukpınar Önsüren, Eda Çetın Özdemır, Fatih Temiz

et al.

Special Care in Dentistry, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 21, 2024

Abstract Aim This study aimed to compare the oral health status between normal weight (NW) and obese (OW) children/adolescents. Methods Eighty‐two participants aged 6–16 years were included in this cross‐sectional study. The children/adolescents classified according body mass index (BMI): NW ( n = 41) OW 41). Caries experience was assessed by International Detection Assessment System (ICDAS‐II), decay, missing, filling teeth (dmft) for primary (DMFT) permanent teeth, erosive tooth wear using Basic Erosive Wear Examination (BEWE), Plaque Index (PI) Gingival (GI), probing depth (PD). Also, relationship procalcitonin (PCT), C‐reactive protein (CRP), parathyroid hormone (PTH), 25(OH)D blood biochemistry evaluated Results Evaluation made of a sum 82 children/adolescents, comprising 43 females 39 males, with median age 14 group 13 group. Significant differences determined patients those who obese, particularly BMI, family income level, brushing habits. results indicate that individuals obesity tend exhibit significantly higher scores PI, GI as compared p < .05) Conclusion Oral hygiene children systemic diseases should be treated multidisciplinary approach under regular control pediatrician pediatric dentist, it may also affect medical

Language: Английский

Lin28b-let-7 Modulates mRNA Expression of GnRH1 Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells DOI Creative Commons

Yujing Xie,

Xin Li, Meng Wang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(2), P. 120 - 120

Published: Jan. 7, 2025

Lin28b and let-7 miRNA regulate mammalian pubertal initiation Gonadotropin-releasing hormone (GnRH) production. However, it remains unclear which signaling pathways regulates to modulate GnRH In this study, the mRNA expression levels of in juvenile goat hypothalamus pituitary gland were detected, decreased significantly compared with that tissues. It was predicted might inhibit GnRH1 expression, verified GnRH-producing cell model GT1-7 cells. inhibited promoted Kiss1/Gpr54 signaling. The pyruvate content Hif1a Hk2, related glycolysis, also by overexpression. Additionally, 77 differentially expressed miRNAs (DEMIs) Lin28b-overexpressed cells identified. Bioinformatics analysis target genes DEMIs revealed MAPK PI3K-AKT-mTOR key involved regulatory effect on GnRH. cells, suppressed blocking mTOR rapamycin, rescued These results indicate Lin28b-let-7 through several pathways, including Kiss1/Gpr54, MAPK, are all glucose metabolism provide new insights into molecular mechanism role

Language: Английский

Citations

0
Lipidomic Analysis of Serum Lipid Profiles in Idiopathic Central Precocious Puberty and the Potential Regulatory Role of GnRHa in Lipid Metabolism DOI Open Access
Lixia Yang, Hui Chen,

Yanhua Jiang

et al.

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 5, 2025

Idiopathic central precocious puberty (ICPP) is an endocrine disorder increasingly observed in children, commonly treated with gonadotropin-releasing hormone agonists (GnRHa). However, the serum lipid profiles girls ICPP and potential regulatory effects of GnRHa metabolism remain unclear. This research analyzed lipidomic samples from younger than 10 years age, including 37 patients ICPP, 32 GnRHa, 30 age-matched healthy controls. Using UHPLC-Q-Exactive Orbitrap/MS, we identified a total 898 differential lipids both positive negative modes, covering classes such as phosphatidylcholine (PC, EtherPC), acylcarnitine (CAR), triglyceride (TG), N-acyl ethanolamines (NAEs), diacylglycerol (DG), sphingomyelin (SM), phosphatidylethanolamine (PE), ceramide (Cer), fatty acids (FAs). In cohort, 105 exhibited significant differences compared controls, increased levels CAR, SM, PC, PE, TG, FA (p < 0.05), notably decreased NAE 0.05). Specifically, 20:1 (AUC: 1.0), 18:2 0.948), 20:0 0.895) were diagnostic biomarkers for ICPP. Following treatment, peak LH FSH decreased, alongside reversible changes 44 lipids, predominantly NAE, TG. conclusion, this study demonstrates that associated alterations metabolism. The induced by therapy suggest link between treatment homeostasis, which warrants further investigation to refine therapeutic approaches potentially mitigate metabolic disorders.

Language: Английский

Citations

0
Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats DOI Creative Commons
Julio Sierra, Timothy B. Simon,

Darine Abu Hilal

et al.

Hormones and Behavior, Journal Year: 2025, Volume and Issue: 171, P. 105744 - 105744

Published: April 18, 2025

Language: Английский

Citations

0
Insights into the Sex-Related Effects of Dietary Polyphenols and Metabolic Disruptors on Inflammatory and (Neuro) Endocrine Pathways in Obesity: The HEAL Project DOI Open Access
Carmela Santangelo, Beatrice Scazzocchio, Rosaria Varı́

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3595 - 3595

Published: Oct. 23, 2024

this study was performed under the umbrella of Health Extended Alliance for Innovative Therapies, Advanced Lab Research, and Integrated Approaches Precision Medicine (HEAL ITALIA) partnership funded National Recovery Resilience Plan, Mission 4 Component 2 Investment 1.3, by European Union.

Language: Английский

Citations

1
Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats DOI Creative Commons
Julio Sierra, Timothy B. Simon,

Darine Abu Hilal

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Childhood obesity is a multifactorial disease affecting more than 160 million adolescents worldwide. Adolescent exposure to obesogenic environments, characterized by access high-fat diets and stress, precipitates maladaptive eating habits in adulthood such as binge eating. Evidence suggests strong association between Western-like high-saturated-fat (WD) food consumption dysregulated hormone fluctuations. However, few studies have explored the long-term impact of adolescent WD psychosocial stress on brain behavior. This longitudinal study aimed investigate an diet resiliency increased susceptibility for binge-like behaviors. male Lewis rats were given (41% fat; n=40) or control (CD, 16% n=38) 4 weeks before undergoing paradigm predator social instability (CDE, WDE, CDU, WDU; n=16/group). Subjects provided intermittent (24 h/week) evaluate eating-like behavior adulthood. Fecal corticosterone testosterone measured at four timepoints throughout adolescence exhibited body weight (p = 0.0217) elevated mid-adolescence (p=0.0312) blunted stress-induced response mid-late (CDE:WDE, p=0.028). levels negatively correlated with bingeing explained variability adult expressing hyperphagic hypophagic These results demonstrate that disrupts fluctuations responsivity, effects persisting into underscores importance addressing environments early mitigate their lasting regulation responsiveness.

Language: Английский

Citations

0
Erosive tooth wear, dental decay, and periodontal health in obese and normal weight children and adolescents DOI Open Access
Aslı Soğukpınar Önsüren, Eda Çetın Özdemır, Fatih Temiz

et al.

Special Care in Dentistry, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 21, 2024

Abstract Aim This study aimed to compare the oral health status between normal weight (NW) and obese (OW) children/adolescents. Methods Eighty‐two participants aged 6–16 years were included in this cross‐sectional study. The children/adolescents classified according body mass index (BMI): NW ( n = 41) OW 41). Caries experience was assessed by International Detection Assessment System (ICDAS‐II), decay, missing, filling teeth (dmft) for primary (DMFT) permanent teeth, erosive tooth wear using Basic Erosive Wear Examination (BEWE), Plaque Index (PI) Gingival (GI), probing depth (PD). Also, relationship procalcitonin (PCT), C‐reactive protein (CRP), parathyroid hormone (PTH), 25(OH)D blood biochemistry evaluated Results Evaluation made of a sum 82 children/adolescents, comprising 43 females 39 males, with median age 14 group 13 group. Significant differences determined patients those who obese, particularly BMI, family income level, brushing habits. results indicate that individuals obesity tend exhibit significantly higher scores PI, GI as compared p < .05) Conclusion Oral hygiene children systemic diseases should be treated multidisciplinary approach under regular control pediatrician pediatric dentist, it may also affect medical

Language: Английский

Citations

0