Effects of a 12‐Week Mediterranean‐Type Time‐Restricted Feeding Protocol in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Controlled Trial—The ‘CHRONO‐NAFLD Project’

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

ABSTRACT Background The Mediterranean diet (MD) is considered the best dietary approach for patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). Recently, time‐restricted feeding (TRF) has gained attention its lifestyle compatibility and health benefits. Aims This study aimed to compare effects of a hypocaloric MD 10‐h TRF protocol an unrestricted in MASLD overweight/obesity evaluate differences between early late TRF. Methods 12‐week randomised controlled trial consisted three groups, all following Mediterranean‐type diet. control group had no eating time restrictions. (eTRF) (lTRF) groups window, from 8 AM 6 PM 12 10 PM, respectively. Various parameters were measured. Compliance was tracked via food diaries, 8‐week follow‐up occurred post‐intervention. Results Fifty‐nine individuals (27 males; 52.9 years; body mass index 32.1 kg/m 2 ) completed (control, n = 19; eTRF, 20; lTRF, 20). All showed significant reductions weight, anthropometry blood pressure. Glycated haemoglobin A 1c insulin resistance, as measured by Matsuda index, homeostatic model assessment resistance fasting glucose‐to‐insulin ratio, improved eTRF at weeks. Conclusions corroborates efficacy ameliorating cardiometabolic risk factors such weight pressure patients. combination may improve glycaemic (NCT05866744). Trial Registration registered clinicaltrials.gov (NCT05866744)

Language: Английский

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Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 169 - 169

Published: Jan. 2, 2025

Aims: To evaluate the effectiveness of a dual approach involving time-restricted eating (TRE) at different times day combined with physical activity (PA) on functional capacity and metabolic health in overweight or obese women. Methods: Random allocation sixty-one participants into four groups: early plus (ETRE-PA, n = 15, 31.8 ± 10.76 years, 89.68 13.40 kg, 33.5 5.53 kg/m2), late (LTRE-PA, 30.60 7.94 94.45 15.36 34.37 7.09 only (LTRE, 27.93 9.79 88.32 10.36 32.71 5.15 kg/m2) control group (CG, 36.25 11.52 89.01 11.68 33.66 6.18 kg/m2). The intervention lasted for 12 weeks all groups. Both ETRE-PA LTRE-PA groups engaged rigorous aerobic resistance-training program. Results: Significant reductions body weight mass index were observed compared to CG LTRE post-intervention (p < 0.0005). Only exhibited significant decrease fat 0.02), low-density lipoprotein cholesterol 0.01), aspartate aminotransferase 0.002). alanine levels 0.004) 0.02) These two latter achieved higher performances 6-min walking test, bench press, 30-s squat, crunch vertical jump 0.0005 both), leg extension 0.02 both) when Conclusion: integration TRE PA leads greater improvements composition, lipid profile, performance, no differences between approaches. This strategy offers promising solution

Language: Английский

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Early Time-Restricted Eating Improves Weight Loss While Preserving Muscle: An 8-Week Trial in Young Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1022 - 1022

Published: March 14, 2025

Background: Time-restricted eating (TRE) has gained attention as a novel dietary intervention that restricts the daily window, potentially offering improved metabolic health and body composition. Nevertheless, whether early TRE (eTRE) or delayed (dTRE) best enhances resistance training (RT) adaptations remains unclear. Methods: In this 8-week randomized study, 24 healthy young women with limited RT experience were assigned into one of three groups: eTRE (an 8:00 AM–2:00 PM feeding window), dTRE (12:00 PM–6:00 PM), control (8:00 AM–8:00 PM). Apart from timing restrictions, no further guidance was provided. All participants performed standardized knee-supported push-ups (4 sets × 10 reps, sessions/week). The primary outcomes included weight, thickness triceps brachii long head (measured via ultrasound), push-up endurance. Results: group achieved significant reduction in weight (−2.61 ± 1.06 kg; p < 0.001), which surpassed changes observed both (−1.44 1.12 kg) (−0.48 0.64 groups. However, between-group differences emerged for muscle performance. groups showed comparable improvements (a 1.36–1.55 mm increase) endurance (62–74 additional repetitions). Conclusions: Early PM) appears to be more beneficial than management when combined RT, yet regimens result similar These findings suggest optimizing meal alignment circadian rhythms may enhance without hindering adaptations, providing practical approach individuals seeking lose while preserving increasing their muscular fitness. Future research involving larger samples diverse populations is warranted confirm these results clarify underlying mechanisms.

Language: Английский

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Impact of bedroom light exposure on glucose metabolic markers and the role of circadian-dependent meal timing: A population-based cross-sectional study

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117589 - 117589

Published: Dec. 26, 2024

Language: Английский

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