Tryptophan metabolites profile predict remission with dietary therapy in pediatric Crohn’s disease

Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Background: Crohn’s disease (CD) exclusion diet combined with partial enteral nutrition (CDED + PEN) or exclusive (EEN) is effective in inducing remission mild-to-moderate pediatric CD. Although CDED PEN better tolerated and has higher compliance compared to EEN, a subset of patients does not achieve remission. Diet-induced shown be positively associated specific changes tryptophan-metabolites. Objectives: To investigate whether the abundance baseline fecal tryptophan-metabolites predicts dietary therapy outcomes Design: Diagnostic accuracy study secondary analysis previously conducted Randomized Controlled Trial (RCT). Methods: Twenty-six from performed RCT CD were included. The classified as having clinical (R) ( n = 19 total; 10 EEN 9) No-Remission (NR) 7 3 4) following 6 weeks therapy, based on Pediatric Disease Activity Index score (⩽10 remission). We targeted quantitative 21 t 0) samples both groups, utilizing liquid chromatography coupled quadrupole mass spectrometry. Receiver operator characteristic curve (ROC) random forest (RFA) used assess predictive power for at baseline. Ratios different downstream tryptophan pathways. Results: Baseline kynurenine level was significantly NR R p 0.02) 0.04). ROC highlighted robust (area under (AUC 0.97)) 0.88)-induced RFA corroborated these observations. ratio serotonin/kynurenine strongest predictor PEN-induced 1). 5-hydroxytryptophan/kynurenine 0.88) predicted EEN-induced By combining data 0.91) ratios quinolinic acid/kynurenine 0.93) kynurenine/indole-3-acetic acid demonstrated strong performance therapy-induced Conclusion: metabolites have potential serve biomarker Some metabolite showed most promising capabilities. If confirmed validation studies, markers may able provide much-needed guidance personalize intervention within management registration: NCT01728870.

Language: Английский

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Maternal consumption of urbanized diet compromises early-life health in association with gut microbiota

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 2, 2025

Urbanization has significantly transformed dietary habits worldwide, contributing to a globally increased burden of non-communicable diseases and altered gut microbiota landscape. However, it is often overlooked that the adverse effects these changes can be transmitted from mother offspring during early developmental stages, subsequently influencing predisposition various later in life. This review aims delineate detrimental maternal urban-lifestyle diet (urbanized diet) on early-life health assembly, provide mechanistic insights how urbanized mediates mother-to-offspring transfer bioactive substances both intrauterine extrauterine thus affects fetal neonatal development. Moreover, we also further propose framework for developing microbiome-targeted precision nutrition strategies specifically pregnant lactating women. The establishment such knowledge help develop proactive preventive measures beginning life, ultimately reducing long-term risk disease improving public outcomes.

Language: Английский

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Placental Bioenergetics and Antioxidant Homeostasis in Maternal Obesity and Gestational Diabetes

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 858 - 858

Published: July 18, 2024

Maternal obesity has been associated with short- and long-term risks of pregnancy-perinatal adverse events, possibly due to alterations placental mitochondrial bioenergetics. However, several detrimental mechanisms occurring in the placentas women still need be clarified. Here, we analyzed features oxidative environment 46 pregnancies relation pre-pregnancy BMI. Seventeen Caucasian normal-weight (NW) twenty-nine who were obese (OB) enrolled. The protein expression CypD electron transfer chain complexes (C) I–V measured, as well ATP production oxygen consumption rates (OCRs). levels pro/anti-oxidant enzymes TXNIP, SOD2, PON2 also analyzed. Despite no differences expression, OCRs significantly lower OB vs. NW women. Accordingly, synthase (CV) content decreased women, positively correlating efficiency, suggesting a link between deficiency dysfunction. SOD2 negatively correlated maternal BMI, indicating possible impairment antioxidant defenses increasing These changes worsened 10 presenting gestational diabetes mellitus. Overall, these results suggest bioenergetics obesity, leading dysfunction altered fetal development programming.

Language: Английский

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Short-chain fatty acids in fetal development and metabolism

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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