Food Phytochemicals as Epigenetic Modulators in Diabetes: A Systematic Review

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101873 - 101873

Published: March 1, 2025

Language: Английский

Cruciferous vegetables improve glycaemic control compared to root/squash vegetables in a randomized, controlled, crossover trial: The VEgetableS for vaScular hEaLth (VESSEL) study

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Abstract Aims Higher cruciferous vegetable (e.g., broccoli) intake is associated with lower risk of type 2 diabetes and cardiovascular disease, but limited causal evidence exists. We investigated if improved glycaemic control compared to root/squash vegetables in non‐diabetic adults elevated blood pressure. Materials Methods This randomized, controlled, crossover trial consisted two 2‐week dietary interventions (300 g/day [active] [control] soups standardized lunch/dinner meals) separated by a washout. Participants were blinded the intervention allocation. Glycaemic measures pre‐specified secondary outcome. Flash glucose monitoring measured interstitial every 15‐min throughout both interventions. Mealtimes consumption recorded food diaries. Differences continuous glucose, variability (coefficient variation [CV]), overall, lunch, dinner postprandial response (PPGR; 2‐h mean [PPGR 2‐h] area under curve [AUC]) assessed using linear mixed‐effects regression. Results Eighteen participants (female = 89%) completed study (median [IQR] age: 68 [66–70 years]). was active versus (mean difference: −2.0%, 95% CI −2.8, −1.1, p < 0.001). Overall PPGR AUC −0.14 mmol/L, −0.24, −0.04, 0.005 −20.1 mmol/L × min, −34.1, −6.1, 0.005, respectively), driven ( 0.004 0.003, respectively). There no difference for 0.411). Conclusions Cruciferous vegetables. The clinical impact remains uncertain warrants further investigation, particularly individuals impaired control. Clinical Trial Registry registered at www.anzctr.org.au (ACTRN12619001294145).

Language: Английский

New horizons for promising influences of sulforaphane in the management of metabolic syndrome: a mechanistic review

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский