Effect of a novel food rich in miraculin on the oral microbiome of malnourished oncologic patients with dysgeusia

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 14, 2024

Abstract Dysgeusia contributes to the derangement of nutritional status in patients with cancer, as well worsening quality life. The pharmaceutical industry has failed provide effective treatments for suffering from taste disorders. present study provided a novel strategy reduce side effects cancer through administration food supplement approved by European Union, Dried Miracle Berries (DMB), containing taste-modifying glycoprotein miraculin, an adjuvant medical-nutritional treatment. This was done pilot randomized, parallel, triple-blind, and placebo-controlled intervention clinical trial which 31 malnourished dysgeusia receiving antineoplastic treatment were randomized into three arms [standard dose DMB (150 mg DMB/tablet), high (300 DMB/tablet) or placebo freeze-dried strawberry)] months. Patients consumed tablet before each main meal. Using Nanopore methodology, we analyzed oral microbiome using saliva samples. All had dysbiosis terms lower bacterial diversity richness. consumption associated changes composition. Neither selected bacteria, nor perception, type diet, cytokine levels mucositis. Likewise, alcohol tobacco general digestive toxicity due systemic therapy not specific microbiota. standard resulted greater relative abundance Enterococcus Veillonella compared placebo. In particular, some species such Granulicatella elegans , adiacens Streptococcus mutans Gemella morbillorum showed higher abundances standard-dose group; contrast, parasanguinis parvula australis cristatus less abundant. Additionally, revealed negative association between concentrations TNF-α thermophilus pneumoniae dysgalactiae agalactiae. Accordingly, regular changed dysgeusia, may contribute maintaining appropriate immune response without changing perception. However, involved small number participants, further studies are necessary draw robust conclusions data. Highlights exhibit dysbiotic state rich meal months treatment, improves composition dysgeusia. Several i.e., show abundant is negatively highly represented bacteria presence absence mucositis, toxicity, use change perception at end intervention.

Language: Английский

Effect of a novel food rich in miraculin on the intestinal microbiome of malnourished patients with cancer and dysgeusia

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Abstract Dysgeusia contributes to nutritional derangement and worsens the quality of life patients with cancer. Despite different strategies, there is no effective treatment for suffering from taste disorders provided by pharmaceutical industry. We developed a novel strategy reducing side effects in cancer providing food supplement tastemodifying glycoprotein miraculin, which approved European Union, as an adjuvant medical-nutritional therapy. A pilot randomized, parallel, triple-blind, placebo-controlled intervention clinical trial was carried out 31 malnourished dysgeusia receiving antineoplastic treatment, were randomized into three arms: standard dose DMB (150 mg DMB/tablet), high (300 DMB/tablet) or placebo freeze-dried strawberry) months. Patients consumed tablet before each main meal (breakfast, lunch dinner). Using stool samples cancer, we analyzed intestinal microbiome via nanopore methodology. detected differences relative abundances genera Phocaeicola Escherichia depending on treatment. Nevertheless, only Solibaculum genus more abundant standard-dose group after 3 At species level, Bacteroides sp. PHL 2737 presented relatively low abundance both groups, Vescimonas coprocola groups Furthermore, positively associated TNF-α levels Lachnoclostridium Mediterraneibacter abundances, whereas negatively . After DMB, erythrocyte polyunsaturated fatty acids correlated Roseburia , positive association between acetic acid concentration feces. The intake together individualized dietary advice results changes There negative perception group. Changes observed microbiota might contribute maintaining appropriate immune response patients. Since present study involved few participants, further research needed draw robust conclusions.

Language: Английский

Effect of a Novel Food Rich in Miraculin on the Oral Microbiome of Malnourished Oncologic Patients with Dysgeusia

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3414 - 3414

Published: Oct. 8, 2024

Dysgeusia contributes to the derangement of nutritional status in patients with cancer as well worsening quality life. There has been a lack effective treatments for taste disorders provided by pharmaceutical industry.

Language: Английский