Peanut Shell Extract Improves Markers of Glucose Homeostasis in Diabetic Mice by Modulating Gut Dysbiosis and Suppressing Inflammatory Immune Response DOI Open Access

Matthew Bender,

Julianna Santos,

Jannette M. Dufour

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4158 - 4158

Published: Nov. 30, 2024

There is strong evidence that the tripartite interaction between glucose homeostasis, gut microbiota, and host immune system plays a critical role in pathophysiology of type 2 diabetes mellitus (T2DM). We reported previously peanut shell extract (PSE) improves mitochondrial function db/db mice by suppressing oxidative stress inflammation liver, brain, white adipose tissue. This study evaluated impacts PSE supplementation on liver histology, intestinal microbiome composition, innate response diabetic mice. Fourteen were randomly assigned to group (DM, AIN-93G diet) (1% wt/wt for 5 weeks. Six C57BL/6J received diet weeks (control group). Parameters homeostasis included serum insulin, HOMA-IR, HOMA-B, analysis pancreatic tissues insulin glucagon. assessed colon using microarray. Gut composition cecal contents was analyzed 16S rRNA gene amplicon sequencing. improved (decreased concentration, HOMA-B) reduced hepatic lipidosis reversed DM-induced shifts relative abundance sequence variants Enterorhabdus, Staphylococcus, Anaerotruncus, Akkermansia. Relative DM mice, had suppressed expression levels Cd8α, Csf2, Irf23 increased Tyk2, Myd88, Gusb liver. demonstrates T2DM-associated disorders part due suppression inflammation.

Language: Английский

Beneficial Effects of Ginger Root Extract on Pain Behaviors, Inflammation, and Mitochondrial Function in the Colon and Different Brain Regions of Male and Female Neuropathic Rats: A Gut–Brain Axis Study DOI Open Access

Julianna Santos,

Hemalata Deshmukh,

Moamen M. Elmassry

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3563 - 3563

Published: Oct. 21, 2024

Neuroinflammation and mitochondrial dysfunction have been implicated in the progression of neuropathic pain (NP) but can be mitigated by supplementation with gingerol-enriched ginger (GEG). However, exact benefits GEG for each sex treating neuroinflammation homeostasis different brain regions colon remain to determined.

Language: Английский

Citations

4
Alzheimer’s disease and diabetes-associated cognitive dysfunction: the microglia link? DOI
Yaqiong Liu, Li Tao, Jun Xiong

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 4, 2025

Language: Английский

Citations

0
Peanuts (Arachis hypogea L.) in Food Industry and their Benefits for Human Health – a Review of the Current Literature DOI

Nathalia. M. Mendes,

Yandra Cervelim Nunes,

Enzo Pereira de Lima

et al.

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107574 - 107574

Published: April 1, 2025

Language: Английский

Citations

0
Peanut Shell Extract Improves Markers of Glucose Homeostasis in Diabetic Mice by Modulating Gut Dysbiosis and Suppressing Inflammatory Immune Response DOI Open Access

Matthew Bender,

Julianna Santos,

Jannette M. Dufour

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4158 - 4158

Published: Nov. 30, 2024

There is strong evidence that the tripartite interaction between glucose homeostasis, gut microbiota, and host immune system plays a critical role in pathophysiology of type 2 diabetes mellitus (T2DM). We reported previously peanut shell extract (PSE) improves mitochondrial function db/db mice by suppressing oxidative stress inflammation liver, brain, white adipose tissue. This study evaluated impacts PSE supplementation on liver histology, intestinal microbiome composition, innate response diabetic mice. Fourteen were randomly assigned to group (DM, AIN-93G diet) (1% wt/wt for 5 weeks. Six C57BL/6J received diet weeks (control group). Parameters homeostasis included serum insulin, HOMA-IR, HOMA-B, analysis pancreatic tissues insulin glucagon. assessed colon using microarray. Gut composition cecal contents was analyzed 16S rRNA gene amplicon sequencing. improved (decreased concentration, HOMA-B) reduced hepatic lipidosis reversed DM-induced shifts relative abundance sequence variants Enterorhabdus, Staphylococcus, Anaerotruncus, Akkermansia. Relative DM mice, had suppressed expression levels Cd8α, Csf2, Irf23 increased Tyk2, Myd88, Gusb liver. demonstrates T2DM-associated disorders part due suppression inflammation.

Language: Английский

Citations

0