Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

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Effects of Plant-Based Diet on Metabolic Parameters, Liver and Kidney Steatosis: A Prospective Interventional Open-label Study

British Journal Of Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 10, 2025

Abstract This interventional single-center prospective open-label study aims to evaluate the effects of a vegan diet, compared vegetarian and omnivorous on metabolic parameters, insulin sensitivity, liver kidney steatosis in healthy adults. The included 53 participants aged 18-40 years, body-mass index 18-30 kg/m2, without any chronic disease, medication use, active smoking, or significant alcohol consumption. All were at baseline selected continue an diet transition with follow-up over six months. Anthropometric measurements, biochemical assessed after months using magnetic resonance imaging-proton density fat fraction (MRI-PDFF). Primary outcomes changes steatosis, while secondary alterations anthropometric markers. Among participants, 18 followed 21 adopted 14 transitioned diet. Dietary interventions did not result statistically body mass index, mass, percentage, muscle However, improvements systolic diastolic blood pressure, favoring observed. We aimed control for potentially confounding variables ensure reliability these findings. have demonstrated better decline lower pole, total hilus Liver 6 vegans. that plant-based is associated several parameters may reduce steatosis.

Language: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 241 - 241

Published: Jan. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Language: Английский

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YouTube as a Source of Information for Dietary Guidance and Advisory Content in the Management of Non-Alcoholic Fatty Liver Disease

Healthcare, Journal Year: 2025, Volume and Issue: 13(4), P. 351 - 351

Published: Feb. 7, 2025

Background/Objectives: Fatty liver disease (FLD), particularly non-alcoholic fatty (NAFLD), is a growing global health concern that underscores the need for effective dietary management strategies. With over 25% of patients seeking advice through platforms like YouTube, quality and reliability this information remain critical. However, disparity in educational value engagement metrics between professional non-professional content remains underexplored. This study evaluates YouTube's role disseminating FLD management, focusing on reliability, metrics, videos. Methods: cross-sectional systematically analyzed 183 YouTube videos advice. Videos were selected based relevance, English language, non-promotional content. Scoring systems, including DISCERN, Global Quality Score (GQS), Video Information Index (VIQI), employed to assess quality, value. Engagement such as views, likes, dislikes, interaction rates across uploader categories, healthcare professionals, patients, undefined sources. Results: uploaded by professionals demonstrated significantly higher DISCERN scores (4.2 ± 0.8) GQS ratings (4.1 0.6) compared patient-generated (DISCERN: 2.8 0.9; GQS: 3.0 0.7). achieved rates, with median views reaching 340,000 (IQR: 15,000-1,000,000) 450,050 23,000-1,800,000) Nutritional recommendations spanned diverse approaches, low-carb diets, Mediterranean guidance avoid processed foods sugars. A significant proportion lacked evidence-based content, among uploads. Conclusions: represents widely accessed but inconsistent source FLD. While exhibit value, achieves broader engagement, revealing critical gap trusted, accessible guidance. These findings highlight clinicians creators collaborate curating ensuring receive accurate, actionable managing

Language: Английский

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Adherence to the planetary health diet index and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 20, 2025

Adherence to the Planetary Health Diet Index (PHDI) has been shown benefit both individual health and planet. However, its impact on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains unclear. This study aimed investigate relationship between PHDI adherence MASLD risk. We analyzed a cohort of 15,865 adults (aged ≥18 years) using data from National Nutrition Examination Survey (NHANES, 2005-2018). The was derived 24-h dietary assessments comprised scores 15 food groups. Multivariate logistic regression used association MASLD, while restricted cubic spline (RCS) threshold analysis were employed explore potential non-linear relationship. Subgroup analyses conducted assess influence various demographic clinical characteristics observed associations. Mediation performed evaluate indirect effect weighted quantile sum (WQS) nutrients MASLD. Among cohort, 6,125 individuals diagnosed with revealed that higher quintile significantly associated reduced risk in fully adjusted model (OR = 0.610, 95%CI 0.508-0.733, p < 0.001). Notably, nonlinear relationships through RCS (p 0.002). indicated particularly effective reducing among females, those education attainment, living partner. WQS identified saturated fatty acids as most significant factor contributing (weight 0.313). Additionally, BMI waist circumference (81.47 87.66%, respectively) partially mediated risk, suggesting operates, part, circumference. remained robust across multiple sensitivity analyses. Our findings indicate is linked lower providing crucial insights for strategies at mitigating epidemic simultaneously fostering environmental sustainability.

Language: Английский

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Sex-Specific Biochemical and Histopathological Effects of Chronic Meat-Based vs. Plant-Based Burger Consumption in a Rodent Model

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 888 - 888

Published: March 5, 2025

The growing consumption of processed foods, including meat-based and plant-based burgers (PBM), raises concerns about their long-term health effects. While PBM are marketed as healthier alternatives, biochemical histological impacts remain unclear. This study investigates the effects chronic burger on metabolic organ health, considering sex differences. Thirty-six Wistar rats (18 males 18 females) were divided into three groups: control (standard chow), meat burger-fed, burger-fed. Improved chow was prepared using lyophilized powder. Over eight weeks, food intake, weight gain, efficiency ratio (FER) monitored. Serum markers, AST, ALT, urea, creatinine, lipid profile (TG, CHOL, HDL, LDL), leptin, analyzed, alongside histopathological evaluation liver, kidneys, heart. PBM-fed exhibited significantly higher FER than group (p < 0.05). AST ALT levels slightly elevated in meat-fed rats, while had increased urea levels. Triglyceride group, but cholesterol did not differ significantly. leptin both experimental groups, suggesting resistance. Histological findings showed mild hepatic inflammation microvacuolar changes, with minor cardiac fibrosis. These highlight need for further research PBM's

Language: Английский

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Advancing precision medicine in metabolic dysfunction-associated steatotic liver disease

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: May 6, 2025

Language: Английский

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Lights and Shadows of a Vegetarian Diet in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1644 - 1644

Published: May 12, 2025

The prevalence and socioeconomic impact of Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing. Despite the recent Food Drug Administration (FDA) approval Resmetirom as first drug for patients with steatohepatitis (MASH) significant fibrosis, several ongoing clinical trials, lifestyle changes aimed at achieving sustained weight loss remain a cornerstone in management these patients. In addition to regular structured physical activity, diet crucial. Several studies have demonstrated benefits Mediterranean this regard, there also emerging evidence on vegetarian its different patterns. This review aims summarize currently available potential MASLD, well exploring limitations.

Language: Английский

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