Cited by The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches

The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches DOI

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 18 - 18

Published: Dec. 26, 2024

The biological process of aging is influenced by a complex interplay genetic, environmental, and epigenetic factors. Recent advancements in the fields epigenetics senolytics offer promising avenues for understanding addressing age-related diseases. Epigenetics refers to heritable changes gene expression without altering DNA sequence, with mechanisms like methylation, histone modification, non-coding RNA regulation playing critical roles aging. Senolytics, class drugs targeting eliminating senescent cells, address accumulation dysfunctional cells that contribute tissue degradation chronic inflammation through senescence-associated secretory phenotype. This scoping review examines intersection senolytic therapies aging, focusing on their combined potential therapeutic interventions. Senescent display distinct signatures, such as hypermethylation modifications, which can be targeted enhance efficacy. Epigenetic reprogramming strategies, induced pluripotent stem may further complement rejuvenating aged cells. Integrating modulation therapy offers dual approach improving healthspan mitigating pathologies. narrative underscores need continued research into molecular underlying these interactions suggests future directions development, including clinical trials, biomarker discovery, combination synergistically target processes.

Language: Английский

Effects of fermented bamboo fiber on intestinal health and fecal pollutants in weaned piglets DOI

Yubiao Jia,

Qian Huang, Rui Song

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Introduction Weaning stress adversely affects piglet growth and development, thereby reducing the economic efficiency of pig farming operations. Furthermore, feces are a major source environmental pollution, underscoring need for effective strategies to mitigate fecal output at its source. Methods This study investigated effects dietary supplementation with fermented bamboo fiber (FBF) on performance, intestinal barrier integrity, gut microbiota composition, pollutant levels in weaned piglets. A total 144 Duroc × Landrace Yorkshire piglets, 21 days age, were randomly assigned 4 groups, six replicates per group 6 piglets replicate. The control (CON) received basal diet, while three treatment groups fed diet supplemented 1, 1.5, 2% FBF, respectively. trial lasted 30 days. Results findings revealed that FBF fortified barrier, modulated colonic microbial communities, decreased levels. Among 1.5% produced most significant improvements piglets’ performance function, as well strongest interactions greatest reduction pollutants. Discussion These results suggest can alleviate weaning impact feces, identified optimal level.

Language: Английский

Citations

Vitamin B12 Deficiency and Cognitive Impairment: A Comprehensive Review of Neurological Impact DOI