Microbiome-based therapies for Parkinson’s disease DOI Creative Commons
Mudassir Alam,

Kashif Abbas,

Mohd Rais Mustafa

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 6, 2024

The human gut microbiome dysbiosis plays an important role in the pathogenesis of Parkinson’s disease (PD). bidirectional relationship between enteric nervous system (ENS) and central (CNS) under mediation gut-brain axis control gastrointestinal functioning. This review article discusses key mechanisms by which modifications composition function microbiota (GM) influence PD progression motor loss. Increased intestinal permeability, chronic inflammation, oxidative stress, α-synuclein aggregation, neurotransmitter imbalances are some factors that govern pathology progression. bacterial taxa associated with development discussed emphasis on (ENS), as well impact bacteria dopamine production levodopa metabolism. pathophysiology course several inflammatory markers, including TNF-α, IL-1β, IL-6. Emerging therapeutic strategies targeting include probiotics, prebiotics, synbiotics, postbiotics, fecal transplantation (FMT). explored how dietary changes may affect ways can (PD), a focus nutrition-based, Mediterranean, ketogenic diets. comprehensive synthesizes current evidence explores its potential target. Understanding these complex interactions assist novel diagnostic tools treatment options for this neurodegenerative disorder.

Language: Английский

The effect of synbiotics on liver enzymes, obesity indices, blood pressure, lipid profile, and inflammation in patients with non-alcoholic fatty liver: a systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Vali Musazadeh,

Kimia Assadian,

Fatemeh Rajabi

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107398 - 107398

Published: Sept. 4, 2024

Language: Английский

Citations

11
Diet and the Gut Microbiome as Determinants Modulating Metabolic Outcomes in Young Obese Adults DOI Creative Commons
E.N. Livantsova, Georgy Leonov, Antonina V. Starodubova

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1601 - 1601

Published: July 18, 2024

Obesity, along with metabolic disorders such as dyslipidemia and insulin resistance, increases the risk of cardiovascular disease, diabetes, various cancers, other non-communicable diseases, thereby contributing to higher mortality rates. The intestinal microbiome plays a crucial role in maintaining homeostasis influencing human metabolism. This study enrolled 82 young obese individuals, who were stratified into groups or without disturbances. No significant differences alpha beta diversity microbiota observed among groups. Insulin resistance was characterized by an increase number Adlercreutzia Dialister well decrease Collinsella, Coprococcus Clostridiales. dyslipidemia+insulin had no gut microbiota. Dietary patterns also influenced microbial composition, high protein intake increasing Leuconostoc Akkermansia, fiber boosting Lactobacillus Streptococcus. genus Erwinia associated visceral fat serum glucose high-density lipoprotein cholesterol. Our findings highlight association between composition disturbances they suggest that dietary modifications may promote healthy reduce developing disorders.

Language: Английский

Citations

4
Role of Antioxidants in Modulating the Microbiota–Gut–Brain Axis and Their Impact on Neurodegenerative Diseases DOI Open Access
Natalia Kurhaluk, Piotr Kamiński, Rafał Bilski

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3658 - 3658

Published: April 12, 2025

This narrative review presents the role of antioxidants in regulating gut microbiota and impact on gut–brain axis, with a particular focus neurodegenerative diseases, such as Alzheimer’s (AD) Parkinson’s disease (PD). These diseases are characterised by cognitive decline, motor dysfunction, neuroinflammation, all which significantly exacerbated oxidative stress. elucidates contribution damage to progression explores potential mitigate these pathological processes through modulation associated pathways. Based recent studies retrieved from reputable databases, including PubMed, Web Science, Scopus, this article outlines mechanisms influence health exert neuroprotective effects. Specifically, it discusses how antioxidants, polyphenols, vitamins, flavonoids, contribute reduction reactive oxygen species (ROS) production thereby promoting neuronal survival minimising brain. In addition, modulating key molecular pathways involved stress NF-κB, Nrf2, MAPK, PI3K/AKT pathways, regulate ROS generation, inflammatory cytokine expression, antioxidant responses essential for maintaining cellular homeostasis both central nervous system. complex relationship between gut-derived metabolites, stress, highlighting dysbiosis—an imbalance microbiota—can exacerbate accelerating AD PD. The also examines short-chain fatty acids (SCFAs) produced beneficial bacteria attenuate neuroinflammation damage. Furthermore, therapeutic microbiota-targeted interventions, delivery probiotics prebiotics, innovative strategies restore microbial support brain health. By synthesising current knowledge interplay underlying neurodegeneration, highlights promise antioxidant-based interventions mitigating progression. It need further research into antioxidant-rich dietary microbiota-focused therapies promising avenues prevention treatment diseases.

Language: Английский

Citations

0
Microbiome-based therapies for Parkinson’s disease DOI Creative Commons
Mudassir Alam,

Kashif Abbas,

Mohd Rais Mustafa

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 6, 2024

The human gut microbiome dysbiosis plays an important role in the pathogenesis of Parkinson’s disease (PD). bidirectional relationship between enteric nervous system (ENS) and central (CNS) under mediation gut-brain axis control gastrointestinal functioning. This review article discusses key mechanisms by which modifications composition function microbiota (GM) influence PD progression motor loss. Increased intestinal permeability, chronic inflammation, oxidative stress, α-synuclein aggregation, neurotransmitter imbalances are some factors that govern pathology progression. bacterial taxa associated with development discussed emphasis on (ENS), as well impact bacteria dopamine production levodopa metabolism. pathophysiology course several inflammatory markers, including TNF-α, IL-1β, IL-6. Emerging therapeutic strategies targeting include probiotics, prebiotics, synbiotics, postbiotics, fecal transplantation (FMT). explored how dietary changes may affect ways can (PD), a focus nutrition-based, Mediterranean, ketogenic diets. comprehensive synthesizes current evidence explores its potential target. Understanding these complex interactions assist novel diagnostic tools treatment options for this neurodegenerative disorder.

Language: Английский

Citations

2