Differential association of seven adiposity parameters with cognitive impairment in the elderly DOI Creative Commons
Jiajun Liu,

Xueshan Jin,

Hongqiang Huang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Background Over the past few years, several studies have indicated that overweight may contribute to decline in cognitive function. This study aimed evaluate how seven adiposity parameters are associated with impairment older adults. Methods In this cross-sectional study, we included data from National Health and Nutrition Examination Survey (NHANES) 2011–2014. Logistic regression was employed relations between various parameters, including body mass index (BMI), arm circumference (AC), waist (WC), waist-to-height ratio (WHtR), roundness (BRI), weight-adjusted (WWI), a shape (ABSI). The best predictor of evaluated using receiver operating characteristic (ROC) curve. Results final 2,909 participants, 726 diagnosed impairment. We found WWI ABSI were significantly positively related (RR: 1.76, 95% CI: 1.50–2.07; RR: 1.09, 1.06–1.12), while AC negatively correlated 0.95, 0.92–0.98). ROC curve results showed Conclusions These suggest clinical practice public health settings, can be used as valid indicators assess

Language: Английский

Associations between heavy metal exposure and vascular age: a large cross-sectional study DOI Creative Commons
Yuntao Feng,

Chengxing Liu,

Lei Huang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 3, 2025

Heavy metal exposure is an emerging environmental risk factor linked to cardiovascular disease (CVD) through its effects on vascular ageing. However, the relationship between heavy and age have not been fully elucidated. This cross-sectional study analyzed data from 3,772 participants in National Health Nutrition Examination Survey (NHANES) 2005 2016. We measured urinary concentrations of nine metals assessed their associations with age, estimated pulse wave velocity (ePWV) heart (HVA). Additionally, sex-stratified analyses, Weighted Quantile Sum (WQS) regression Bayesian Kernel Machine Regression were conducted explore individual mixed exposures. Exposure such as cadmium (Cd) cesium (Cs), cobalt (Co), lead (Pb) was significantly associated increased odds ratios (OR) ranging 1.05 3.48 full adjusted models. Sex-stratified analyses indicated that including (Co) exposures had a more substantial impact males. WQS analysis consistently showed combined stronger men (OR for HVA = 3.89, 95% CI 2.91–5.28). highlights significant association age. Stratified illustrated might be susceptible multiple exposure. The findings underscore importance considering sex-specific responses interventions measures assessments managements. Further research needed validate these develop precise public health strategies targeting risks.

Language: Английский

Citations

1
Association between novel adiposity parameters and hyperuricemia: a cross-sectional study DOI Creative Commons

Baoan Wang,

Chuncheng Ma,

Jinhua Wu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Objectives Body mass index (BMI) is a commonly used parameters to measure obesity, but it cannot well reflect the distribution of body fat, which has limitations in clinical practice. Novel adiposity have emerged as substitution BMI assess obesity. This study aimed comprehensively investigate association between hyperuricemia and novel parameters. Methods We included data from National Health Nutrition Examination Survey 1999–2006. Weighted logistic regression was employed evaluate relations parameters, including roundness (BRI), weight-adjusted waist (WWI), shape (ABSI), conicity (CoI). To most diagnostic factor for hyperuricemia, receiver operating characteristic (ROC) curve analysis employed. The area under (AUC) power each parameter. Results 24,763 participants, 3,528 whom were diagnosed with hyperuricemia. Compared first quartile (Q1), fourth quartile’s (Q4) BRI, WWI, ABSI CoI linked an increased risk (OR: 9.34, 95% CI: 7.73–11.28; OR: 4.67, 3.97–5.49; 2.61, 2.26–3.02; 7.34, 6.12–8.81, respectively). relationship persisted after adjusting confounding factors. Among four obesity BRI had largest AUC good (AUC = 0.697 male 0.751 female). Conclusion In general population, larger are higher high value can be new evaluation provides basis prevention monitoring

Language: Английский

Citations

1
Health effects of mixed metal exposure on accelerating aging among the elderly population DOI Creative Commons

Chuanli Yang,

Jijun Zhang, Haohan Liu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117760 - 117760

Published: Feb. 1, 2025

Human exposure to heavy metals occurs through multiple pathways in daily life. However, the effects of mixed metal on accelerated aging elderly U.S. population remains unclear. This study aims investigate association between concentrations blood and urine onset aging. A total 2530 individuals were included analysis 716 this study. GrimAge acceleration (AgeAccelGrim) was calculated as residuals from regressing DNA methylation chronological age. Weighted multivariable logistic regression models applied analyze relationship with AgeAccelGrim. Bayesian kernel machine (BKMR) performed estimate individual or mixtures We found that cadmium (Cd) concentration positively associated an increased risk AgeAccelGrim both females males, odds ratios (OR) 5.73 (95 % confidence interval CI): 1.88-17.41, P trend = 0.008) 14.25 CI: 4.88-41.62, < 0.001), respectively. Moreover, these associations more pronounced for urinary Cd compared Cd. Blood lead (Pb) also a 3.52-fold 1.21-10.24, 0.007) increase among males. BKMR confirmed aforementioned findings, identifying most significant contributor Exposure metals, either individually mixture, biological These

Language: Английский

Citations

0
Exposure to toxic metals might accelerate aging DOI
Wenqing Wang, Kaixuan Yang, Jiayi Li

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121180 - 121180

Published: Feb. 1, 2025

Language: Английский

Citations

0
The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age DOI Creative Commons
Jiajun Liu, Yihui Fu, Pengpeng Liang

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 28, 2025

Triglyceride glucose index (TyG) serves as an effective parameter for assessing metabolic status. However, it remains uncertain whether TyG and other parameters can predict clinical outcomes in people with syndrome (MetS). We investigated the association of TyG, triglyceride glucose-waist to height ratio (TyG-WHtR), score insulin resistance (METS-IR) all-cause cardiovascular mortality MetS cohort determined this changes age. Participants enrolled National Health Nutrition Examination Survey (NHANES) between 2001 2018 were selected categorized into two groups: younger individuals (age < 65 years) older ≥ years). Three new indices TyG-WHtR, METS-IR constructed. The weighted Cox proportional hazards model restricted cubic spline (RCS) models employed evaluate relation three outcomes. time-dependent receiver operating characteristic (ROC) curve assessed ability different mortality. Sensitivity analysis was conducted robustness reliability findings. study comprised a total 8271 participants, including 5456 participants 2815 1407 deaths observed over median follow-up period 8.3 years. Compared first quartile (Q1), fourth quartile's (Q4) linked increased risk (HR 1.63, 95% CI 1.12–2.39; HR 2.78, 1.68–4.61; 1.36, 1.12–2.02, respectively) 2.04, 1.15–4.90; 4.99, 1.76–14.11; 2.69, 1.89–8.15, group but not group. RCS results showed no significant non-linear associations METS-IR, (P = 0.082; P 0.712; 0.062, or 0.176; 0.793; 0.482, age TyG-WHtR demonstrated highest area under predicting 3-year group, values 0.653 0.688 Our highlight predictive value population, providing evidence medical practice public health. A study, 100 months. Weighted COX regression (left), (upper right), (cut-off 36 months) (lower right). index; WHtR ratio; Metabolic resistance; syndrome.

Language: Английский

Citations

0
Association Between Multiple Plasma Toxic Metal and Metalloid Exposures and Hypertension in Elderly Chinese Adults DOI
Yiwen Zhang, Xin Mu,

Junpu Yu

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism status DOI
Jiajun Liu,

Jinhua Kang,

Pengpeng Liang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Objectives The triglyceride-glucose index (TyG) is a significant parameter for evaluating metabolic health, but its link to mortality across various glucose metabolism statuses still uncertain. purpose of this study was investigate the relationship between TyG and risk all-cause cardiovascular in normoglycemia, dysglycemia, diabetic populations. Methods Participants who took part NHANES nine cycles were chosen divided into three categories: diabetes. Cox regression restricted cubic spline (RCS) models used assess linear nonlinear relations mortality, respectively. To evaluate predictive power atherogenic plasma (AIP) time-dependent ROC curve utilized. Subgroup analyses carried out separately based on age, sex, blood-pressure status. Results After median observation period 9.2 years, 2,199 deaths from all causes 606 cardiovascular-related recorded. In normoglycemic group, single standard unit rise correlated with 37% increase 42% mortality. Among diabetics, RCS revealed U-shaped relation all-cause/cardiovascular threshold value 9.1. No associations identified dysglycemia. outperformed AIP predicting 3-year groups. age-specific interaction TyG-mortality association, significance individuals <65 not ≥65 years age. Conclusion Our findings highlight TyG's role populations different metabolism, contributing new evidence public fields medical practice.

Language: Английский

Citations

0
Differential association of seven adiposity parameters with cognitive impairment in the elderly DOI Creative Commons
Jiajun Liu,

Xueshan Jin,

Hongqiang Huang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Background Over the past few years, several studies have indicated that overweight may contribute to decline in cognitive function. This study aimed evaluate how seven adiposity parameters are associated with impairment older adults. Methods In this cross-sectional study, we included data from National Health and Nutrition Examination Survey (NHANES) 2011–2014. Logistic regression was employed relations between various parameters, including body mass index (BMI), arm circumference (AC), waist (WC), waist-to-height ratio (WHtR), roundness (BRI), weight-adjusted (WWI), a shape (ABSI). The best predictor of evaluated using receiver operating characteristic (ROC) curve. Results final 2,909 participants, 726 diagnosed impairment. We found WWI ABSI were significantly positively related (RR: 1.76, 95% CI: 1.50–2.07; RR: 1.09, 1.06–1.12), while AC negatively correlated 0.95, 0.92–0.98). ROC curve results showed Conclusions These suggest clinical practice public health settings, can be used as valid indicators assess

Language: Английский

Citations

0