Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

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Association between the triglyceride-glucose index and liver fibrosis in adults with metabolism-related fatty liver disease in the United States: a cross-sectional study of NHANES 2017–2020

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 2, 2025

This study aimed to examine the association between triglyceride-glucose (TyG) index and liver fibrosis (LF) in U.S. adults with Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD). Using data from 2017 2020 National Health Nutrition Examination Survey (NHANES) database, we conducted a population-based cross-sectional 1,324 participants. MAFLD was defined as controlled attenuation parameter (CAP) score ≥ 248 dB/m accompanied by metabolic dysfunction. A median stiffness measurement 8.2 kPa used identify significant (≥ F2). Multivariable logistic regression employed assess impact of TyG on LF outcomes. restricted cubic spline (RCS) model explore nonlinear effects, receiver operating characteristic (ROC) curves were applied evaluate effectiveness predicting. Among participants, 716 men 608 women, aged 20 80 years, representing various racial groups. Significant observed 137 out After adjusting for confounding factors, higher significantly associated an increased incidence MAFLD-related (OR = 2.18, 95% CI, 1.14–4.18; p < 0.05). Elevated levels showed positive correlation fibrosis, odds ratio (OR) exceeding 1 when above 8.054. Subgroup analyses stratified sex, age, body mass (BMI) revealed differences after confounders. The stronger women 2.53, 1.16–5.53) than 1.95, 0.81–4.72). also found obesity status (overweight: OR 4.80, 1.27–18.2; obese: 2.26, 1.20–5.53). In patients 40–59, strongly 2.85, 1.16–6.79). Furthermore, area under ROC curve (AUC) predicting 0.73 (95% 0.68–0.78), indicating moderate predictive ability. general population, elevated positively risk patients.

Language: Английский

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Correlation of sarcopenia with progression of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: a study from two cohorts in China and the United States

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 14, 2025

The objective of this study was to investigate the association between sarcopenia and liver fibrosis in patients aged 18–59 years with metabolic dysfunction-associated steatotic disease (MASLD) assess potential as a risk factor for progression fibrosis. included 821 MASLD US cohort 3,405 Chinese cohort. Liver controlled attenuation parameters (CAP) stiffness measurements (LSM) were assessed by vibration-controlled transient elastography (VCTE) evaluate extent hepatic steatosis Sarcopenia measuring appendicular skeletal muscle mass (ASM) calculating ASMI. To analyze relationship sarcopenia, ASMI, fibrosis, logistic regression models, multivariate-adjusted restricted cubic spline (RCS) models employed, stratification interaction analyses. results demonstrated that exhibited markedly elevated significant advanced cirrhosis compared those without both cohorts. After adjusting confounding variables, identified an independent MASLD. A negative correlation observed ASMI severity progressive reduction associated increasing Additionally, non-linear feature evident some indicators. Subgroup analysis further corroborated finding harmful effect on consistent across all subgroups. may be Monitoring assist identifying individuals at patients.

Language: Английский

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Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3191 - 3191

Published: Sept. 20, 2024

Background: Consumption of flavonoid-rich orange juice has been shown to reduce adiposity and liver steatosis in murine models diet-induced obesity. However, little is known about the effects whole intake, independent body weight changes, on function individuals with metabolic dysfunction-associated steatotic disease (MASLD). The goal understand direct impact consumption health. Methods: Sixty-two men women aged 30–65 MASLD (Controlled Attenuation Parameter, (CAP) > 275 dB/m) were randomly assigned consume either 400 g oranges or non-citrus fruits daily for 4 weeks. Baseline evaluations included medical assessments, blood tests, composition. Liver health was assessed using transient elastography (FibroScan®) fibrosis, conducted by blinded personnel. This clinical trial registered at ClinicalTrials.gov (NCT05558592). Results: After weeks supplementation, decreased treatment group, 70.9% showing compared 100% controls (p < 0.004), indicating a 30% reduction prevalence. There no significant changes fibrosis plasma enzymes, though gamma glutaril transferase (GGT) levels significantly. Body weight, waist circumference, composition, lipid profile, fasting glucose, insulin, C-reactive protein remained unchanged. Dietary analysis revealed change caloric but vitamins C, A, thiamine, riboflavin increased group. Conclusions: Our findings suggest that phytochemical-rich foods, especially like oranges, may enhance as an adjunct MASLD. notable prevalence occurred independently changes. Further studies are needed investigate long-term supplementation progression identify specific bioactive compounds mechanisms involved.

Language: Английский

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Potential mechanisms and therapeutic prospects of the association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 6, 2025

Helicobacter pylori (H. pylori) infection is a known inducer of various gastrointestinal diseases, including gastritis, gastric ulcers, and cancer. However, in recent years, research on the potential association between H. metabolic dysfunction-associated steatohepatitis (MASH) has been scarce. This large-scale multicenter study, covering more than 360 hospitals across 26 medical systems United States, systematically evaluated MASH. paper reviews innovative aspects this discusses its significance current field liver analyzes molecular mechanisms, suggests future directions therapeutic prospects.

Language: Английский

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Impact of bariatric surgery on liver fibrosis indices among type 2 diabetes patients in a national cohort

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

Obesity is related to liver fibrosis, a condition marked by the collection of scar tissue in due development profibrotic environment, which includes increased hepatocellular death and elevated reactive oxygen species production. The aim study evaluate effect bariatric surgery on association between fibrosis indices obesity. This retrospective cohort, evaluating 1205 individuals diagnosed with type 2 diabetes (T2D) living obesity, who experienced surgery. These patients T2D obesity were monitored after for two years. trajectory biochemical markers evaluated at five visits. Fibrosis-4 (FIB-4) index, aspartate aminotransferase (AST) platelet ratio non-alcoholic fatty disease (NAFLD) score. FIB-4 index demonstrated notable trends based its values. It showed an initial increase observed three-months visit, followed decline up one year slight last follow-up (P-trend < 0.001). should be mentioned that, mean ≥ 1.3 (pre-operation) did not exceed value 2.00, lower than cut-off high risk cirrhosis (FIB-4 2.67). In addition, NAFLD score (NFS) substantial from − 0.32 ± 1.32 pre-operation -0.86 1.15 two-year mark Finally, AST (APRI) decreased 0.27 0.20 0.23 0.12 12-month follow-up. Bariatric significantly improves NFS cause alterations APRI Fib-4 levels without increasing among

Language: Английский

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Inhibiting DPP4 activity protects hiPSC-derived steatotic HLCs by supporting fatty acid and purine metabolism and dampening inflammation

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Background Metabolic dysfunction-associated steatotic liver disease (MAFLD) has a high prevalence and co-morbidity for other diseases. Due to the complexity of this multifactorial disease, therapy options are still rather limited. We employed an in vitro pluripotent stem cell-based model decipher basic disease-associated molecular pathways study mode action potential drugs. Methods induced steatosis phenotype in human cell (iPSC) derived hepatocyte-like cells (HLCs) by oleic acid (OA)-feeding confirmed regulation clinically relevant NGS-based global transcriptomic analyses. Analysis secretome HLCs revealed Dipeptidyl peptidase 4 (DPP4) as key mediator disease. To further elucidate its role development MAFLD, we inhibited DPP4 activity with Vildagliptin (VILDA) analyzed transcriptome changes well specific gene protein expression steatosis-associated genes without inhibition. Results MAFLD-associated such PPAR- TNF signaling were differentially regulated hiPSC-derived HLCs. found increased hepatic secretion upon OA. Fatty purine metabolism inflammation response improved Conclusions Our HLC-model clinically-relevant association which foster MAFLD. Inhibiting VILDA partially relieved phenotype. Trial registration Not applicable Impact implications: Given difficulties identifying suitable anti-MAFLD drugs, novel systems urgently needed. reproduced DPP4-dependent aspects responded positively treatment. Further elucidation etiology MAFLD is warranted.

Language: Английский

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Lipids dysregulation in diseases: core concepts, targets and treatment strategies

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 21, 2025

Lipid metabolism is a well-regulated process essential for maintaining cellular functions and energy homeostasis. Dysregulation of lipid associated with various conditions, including cardiovascular diseases, neurodegenerative disorders, metabolic syndromes. This review explores the mechanisms underlying metabolism, emphasizing roles key species such as triglycerides, phospholipids, sphingolipids, sterols in physiology pathophysiology. It also examines genetic environmental factors contributing to dysregulation challenges diagnosing managing lipid-related disorders. Recent advancements lipid-lowering therapies, PCSK9 inhibitors, ezetimibe, bempedoic acid, olpasiran, provide promising treatment options. However, these are accompanied by related cost, accessibility, patient adherence. The highlights need personalized medicine approaches address interplay between genetics metabolism. As lipidomics advanced diagnostic tools continue progress, deeper understanding disorders could pave way more effective therapeutic strategies.

Language: Английский

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Research Progress of the Relationship between Metabolic-Associated Fatty Liver Disease and Colorectal Neoplasia

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1996 - 2004

Published: Jan. 1, 2025

Language: Английский

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Healthy adipose tissue after menopause: contribution of balanced diet and physical exercise

Published: March 14, 2025

The accumulation of adipose tissue is associated with metabolic disorders, including insulin resistance, type 2 diabetes (T2D), dyslipidemia, syndrome, and cardiovascular diseases (CVD). Menopause might predispose women to increase body weight tissue, decrease lean muscle mass. Furthermore, postmenopausal display fat mass redistribution greater in the visceral area mainly due hormonal shifts that result a higher testosterone/estradiol ratio. These effects are less favorable adipokine profile, cardiac dysfunction after menopause. Fat determined by balance between storage triacylglycerol (TAG) (lipogenesis) removal stored TAG (lipolysis) combination differentiation new adipocytes (adipogenesis). Disturbances dynamics lead an lipogenesis (hypertrophy) and/or adipogenesis (hyperplasia) accommodate excess energy intake. While large dysfunctional have secretion inflammatory adipocytokines, small healthier improvements. Different strategies can be used prevent or reduce gain mass, as well maintain healthy tissue; however, robust evidence, lifestyle interventions should pillars this process. This review provides comprehensive summary findings on role balanced diet physical exercise improving composition promoting women.

Language: Английский

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