Cited by Principles of Nutrition in Patients with Nonalcoholic Fatty Liver Disease

The Impact of Dietary Interventions on Metabolic Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Comorbid Conditions, Including Obesity and Type 2 Diabetes DOI

Joanna Michalina Jurek,

Katarzyna Zablocka-Sowinska,

Helena Clavero Mestres

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1257 - 1257

Published: April 3, 2025

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a public health concern, linked with immune-metabolic dysfunction. While lifestyle and dietary modifications remain the cornerstone of MASLD management, optimal approach remains uncertain. Objectives: This systematic review aims to investigate impact model patterns on metabolic outcomes in patients evaluate their effects individuals coexisting conditions, such as obesity, syndrome, type 2 diabetes mellitus (T2DM). Methods: To conduct review, PubMed, Scopus, Google Scholar, Cochrane CENTRAL, ClinicalTrials.gov databases were searched for Randomized Controlled Trials (RCTs) adult population, published between January 2019 September 2024, following PRISMA principles. The quality included RCTs was assessed qualitatively based study characteristics. Results: main findings this demonstrated that use interventions Mediterranean diet (MED) intermittent fasting (IF) approaches, alternative-day (ADF) time-restricted feeding regimens (TRF) may have potential reducing body weight, BMI, waist circumference, additional benefits improving glycemic control inflammation. hepatic functions, although limited, be reduced enzyme activity stiffness. Additionally, lacto-ovo-vegetarian (LOV-D) Dietary Approaches Stop Hypertension (DASH) offer benefits, including blood pressure management. Conclusions: suggests MED IF-based strategies reduce BW, improve control, lower inflammation, function. Further long-term studies are needed confirm these underlying mechanisms, which will allow optimization protocols ensure safety MASLD.

Language: Английский

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Clinical Study of Intelligent Tongue Diagnosis and Oral Microbiome for Classifying TCM Syndromes in MASLD DOI

Juncai Deng,

Shixuan Dai,

Shi Liu

et al.

Published: April 23, 2025

Abstract Background This study aimed to analyze the tongue image features and oral microbial markers in different TCM syndromes related metabolic dysfunction-associated steatotic liver disease (MASLD). Methods involved 34 healthy volunteers 66 MASLD patients [36 with Dampness-Heat (DH) 30 Qi-Deficiency (QD) syndrome]. Oral microbiome analysis was conducted through 16S rRNA sequencing. Tongue feature extraction used Uncertainty Augmented Context Attention Network (UACANet), while syndrome classification performed using five machine learning methods based on microbiota. Results Significant differences color, coating, microbiota were noted between DH band QD patients. exhibited a red-crimson color greasy coating enriched Streptococcus Rothia tongue. In contrast, displayed pale higher abundances of Neisseria, Fusobacterium, Porphyromonas Haemophilus. Combining characteristics differentiated an AUC 0.939 accuracy 85%. Conclusion suggests that are metabolism, possess distinct biomarkers, supporting classification.

Language: Английский

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Targeting Metabolism: Innovative Therapies for MASLD Unveiled DOI

Weixin Wang, Xin Gao, Wei Niu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4077 - 4077

Published: April 25, 2025

The recent introduction of the term metabolic-dysfunction-associated steatotic liver disease (MASLD) has highlighted critical role metabolism in disease’s pathophysiology. This innovative nomenclature signifies a shift from previous designation non-alcoholic fatty (NAFLD), emphasizing condition’s progressive nature. Simultaneously, MASLD become one most prevalent diseases worldwide, highlighting urgent need for research to elucidate its etiology and develop effective treatment strategies. review examines delineates revised definition MASLD, exploring epidemiology pathological changes occurring at various stages disease. Additionally, it identifies metabolically relevant targets within provides summary latest targeted drugs under development, including those clinical some preclinical stages. finishes with look ahead future therapy goal summarizing providing fresh ideas insights.

Language: Английский

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Unlocking the gut-liver axis: microbial contributions to the pathogenesis of metabolic-associated fatty liver disease DOI

Mykhailo Buchynskyi, Iryna Kamyshna, Iryna Halabitska

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex metabolic disorder characterized by hepatic lipid accumulation and subsequent inflammation. This condition closely linked to syndrome obesity, with its prevalence rising due sedentary lifestyles high-calorie diets. The pathogenesis of MAFLD involves multiple factors, including insulin resistance, lipotoxicity, oxidative stress, inflammatory responses. gut microbiota plays crucial role in development, dysbiosis contributing inflammation through various mechanisms, such as enhanced intestinal permeability the translocation bacterial products like lipopolysaccharide (LPS). Microbial metabolites, short-chain acids (SCFAs) bile acids, influence function immune responses, potential implications for progression. Specific microbiome signatures have been identified patients, offering diagnostic therapeutic targets. Moreover, gut-derived toxins, endotoxins, lipopolysaccharides, trimethylamine-N-oxide significantly damage inflammation, highlighting interplay between health. review comprehensively examines MAFLD, focusing on underlying pathogenic biomarkers, emerging microbiome-targeted strategies management.

Language: Английский

Citations

Addressing the alarming link between nonalcoholic fatty liver disease and cardiovascular mortality in men DOI

Wen‐Rui Hao, Chun‐Han Cheng,

Tzu-Hurng Cheng

et al.

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(9), P. 502 - 507

Published: Sept. 19, 2024

This editorial discusses the key findings presented in Batta and Hatwal’s recent paper titled “Excess cardiovascular mortality men with non-alcoholic fatty liver disease: A cause for concern!”, which was published World Journal of Cardiology . Their original article highlights a notable correlation between nonalcoholic disease (NAFLD) increased risk men. The present commentary explores implications their findings, discussing potential mechanisms, factors, urgent need integrated clinical approaches to mitigate dual burden these diseases. Emphasis should be placed on importance early detection, lifestyle modifications, interdisciplinary collaboration improving patient outcomes. aims highlight broad NAFLD health advocate awareness proactive management strategies within medical community.

Language: Английский

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Inhibiting DPP4 activity protects hiPSC-derived steatotic HLCs by supporting fatty acid and purine metabolism and dampening inflammation DOI

Christiane Loerch,

Wasco Wruck,

R. J. Julian

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Background and Aim Metabolic dysfunction-associated steatotic liver disease (MASLD/MAFLD) has a high prevalence co-morbidity for other diseases. Due to the complexity of this multifactorial disease, therapy options are still rather limited. We employed an in vitro pluripotent stem cell-based model decipher basic disease-associated molecular pathways study mode action potential drugs. Methods induced steatosis phenotype human cell (iPSC) derived hepatocyte-like cells (HLCs) by oleic acid (OA)-feeding confirmed regulation clinically relevant NGS-based global transcriptomic analyses. Analysis secretome HLCs revealed Dipeptidyl peptidase 4 (DPP4) as key mediator disease. To further elucidate its role development MAFLD, we inhibited DPP4 activity with Vildagliptin (VILDA) analyzed transcriptome changes well specific gene protein expression steatosis-associated genes without inhibition. Results MAFLD-associated such PPAR– TNF signaling were differentially regulated hiPSC-derived HLCs. found increased hepatic secretion upon OA. Fatty purine metabolism inflammation response improved Conclusion Our HLC-model clinically-relevant association which foster MAFLD. Inhibiting VILDA partially relieved phenotype. Impact implications Given difficulties identifying suitable anti-MAFLD drugs, novel systems urgently needed. reproduced DPP4-dependent aspects responded positively treatment. Further elucidation etiology MAFLD is warranted.

Language: Английский

Citations

Principles of Nutrition in Patients with Nonalcoholic Fatty Liver Disease DOI

Narges Mobasheri, Leila Ghahremani, Mahin Nazari

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

This chapter will comprehensively address the nutritional principles essential for managing nonalcoholic fatty liver disease (NAFLD). It explore critical role of diet in prevention and treatment NAFLD, providing evidence-based dietary recommendations to improve health overall well-being patients. Key topics include importance balanced macronutrient intake, specific nutrients food groups (e.g., antioxidants, fiber, healthy fats), impact patterns such as Mediterranean Dietary Approaches Stop Hypertension (DASH) on fat reduction inflammation. Additionally, discuss significance weight management, outlining standard amount loss beneficial NAFLD Practical guidelines how implement these changes, overcome common barriers, maintain long-term adherence be provided. aims equip healthcare professionals patients with knowledge tools necessary effectively manage through diet, ultimately improving patient outcomes quality life.

Language: Английский

Citations