Gluten-Free Diet Adherence Evaluation in Adults with Long-Standing Celiac Disease DOI Creative Commons
Marek Kowalski, Danuta Domżał-Magrowska, Piotr Szcześniak

et al.

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 76 - 76

Published: Dec. 31, 2024

Background: Celiac disease (CD) is an autoimmune that results from the interaction of genetic, immune, and environmental factors. According to 2020 European Society for Pediatric Gastroenterology Hepatology Nutrition (ESPGHAN) guidelines, elimination diet (i.e., excluding products may contain gluten) basic method treating celiac disease. Following a gluten-free extremely problematic, patients often make unconscious deviations diet. current Oslo definitions disease, depending on clinical picture adequate tests, several forms have been identified: typical, atypical, asymptomatic, potential, refractory. Objective: The aim study was assess frequency conscious mistakes in group with long-standing their impact typical atypical symptoms. Methods: included 57 people diagnosed between 1980 2010. After verifying history according ESPGHAN guidelines 2020, we excluded 19 who had Marsh grade 1 at time diagnosis or those without HLA DQ2 DQ8 haplotypes detected. verification, 38 patients, 30 women 8 men, verified effectiveness assessed all participants. Blood collected determine IgA anti-tissue transglutaminase II antibodies (anti-tTG) IgG against deamidated gliadin peptides by ELISA. All survey participants provided data concerning gastrointestinal systemic symptoms, bowel habits, comorbidities, dietary physical activity, socioeconomic conditions. Results: A total 25 (65.78%) declared strict adherence However, this group, seven (18.4%) significantly increased levels anti-tTG (mean 82.3 RU/mL ± 78.9 SD N < 20 RU/mL). Among consciously made mistakes, six (46.2%) demonstrated antibodies. analysis did not reveal any difference intestinal extraintestinal symptoms making following Conclusions: More than half unconsciously which indicates urgent need increase general knowledge CD appropriate Regardless whether followed, both observed among patients.

Language: Английский

Gluten-Free Diet Adherence Evaluation in Adults with Long-Standing Celiac Disease DOI Creative Commons
Marek Kowalski, Danuta Domżał-Magrowska, Piotr Szcześniak

et al.

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 76 - 76

Published: Dec. 31, 2024

Background: Celiac disease (CD) is an autoimmune that results from the interaction of genetic, immune, and environmental factors. According to 2020 European Society for Pediatric Gastroenterology Hepatology Nutrition (ESPGHAN) guidelines, elimination diet (i.e., excluding products may contain gluten) basic method treating celiac disease. Following a gluten-free extremely problematic, patients often make unconscious deviations diet. current Oslo definitions disease, depending on clinical picture adequate tests, several forms have been identified: typical, atypical, asymptomatic, potential, refractory. Objective: The aim study was assess frequency conscious mistakes in group with long-standing their impact typical atypical symptoms. Methods: included 57 people diagnosed between 1980 2010. After verifying history according ESPGHAN guidelines 2020, we excluded 19 who had Marsh grade 1 at time diagnosis or those without HLA DQ2 DQ8 haplotypes detected. verification, 38 patients, 30 women 8 men, verified effectiveness assessed all participants. Blood collected determine IgA anti-tissue transglutaminase II antibodies (anti-tTG) IgG against deamidated gliadin peptides by ELISA. All survey participants provided data concerning gastrointestinal systemic symptoms, bowel habits, comorbidities, dietary physical activity, socioeconomic conditions. Results: A total 25 (65.78%) declared strict adherence However, this group, seven (18.4%) significantly increased levels anti-tTG (mean 82.3 RU/mL ± 78.9 SD N < 20 RU/mL). Among consciously made mistakes, six (46.2%) demonstrated antibodies. analysis did not reveal any difference intestinal extraintestinal symptoms making following Conclusions: More than half unconsciously which indicates urgent need increase general knowledge CD appropriate Regardless whether followed, both observed among patients.

Language: Английский

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