Hepatoprotective, Lipid-Lowering and Antioxidant Effects of Mangaba Powder (Hancornia speciosa) Administered to Rats Fed a High-Fat Diet DOI Creative Commons

Bernadete de Lourdes de Araújo Silva,

Margarida Angélica da Silva Vasconcelos, Kamila Sabino Batista

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3773 - 3773

Published: Nov. 25, 2024

The aim of this study was to evaluate the potential effects administering mangaba powder on liver function and somatic, oxidative lipid metabolism parameters in rats fed a high-fat diet. Prepared has important amounts phenolic compounds, vitamin C, dietary fiber oligosaccharides. A total 32 adult Wistar were initially randomized into two groups for biological assay: normal-fat (NF, n = 16) (HF, diets 21 days. These subsequently subdivided four groups: NF (n 8), HF diet with administration (NFMG, 8) (HFMG, 8). treatment (400 mg/kg) lasted an additional 28 Compared rats, HFMG showed 8% reduction body mass index. Treatment reduced serum cholesterol by 18%, as well hepatic deposition triacylglycerides 26% 25%, addition increasing bile acid synthesis 77% organ. Mangaba consumption attenuated degree steatosis, peroxidation increased antioxidant capacity rats. results show that had lipid-lowering, hepatoprotective effects, especially which may be associated additive synergistic action between bioactive compounds present product.

Language: Английский

Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols DOI Creative Commons

Raissa Bulaty Tauil,

Paula Takano Golono, Enzo Pereira de Lima

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

Citations

12
Hemp seed protein exerts its hypoglycemic and hypolipidemic effects through degradation into short peptides DOI
Mingchen Liu, Yicheng Li, Wentao Li

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144406 - 144406

Published: April 1, 2025

Language: Английский

Citations

0
Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond DOI Creative Commons
Ting Tai,

Yuan-Yuan Shao,

Y. H. Zheng

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 23, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) frequently confers an increased risk of vascular thrombosis; however, the marketed antiplatelet drugs are investigated for prevention and treatment MASLD in patients with these coexisting diseases.

Language: Английский

Citations

1
Pea Albumin Alleviates Oleic Acid-Induced Lipid Accumulation in LO2 Cells Through Modulating Lipid Metabolism and Fatty Acid Oxidation Pathways DOI Creative Commons
Bing Fang, Jie Luo,

Zhengwu Cui

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3482 - 3482

Published: Oct. 30, 2024

Excessive lipid accumulation in the liver can cause NAFLD, leading to chronic injury. To relieve by dietary proteins, this study used oleic acid (OA) induction establish a stable vitro LO2 cell model. This model was explore mechanism which pea albumin (PA) regulates levels cells. PA has been shown ameliorate OA-induced cells reducing aggregation of intracellular droplets and lowering TG TC levels. In addition, it alleviate damage oxidative stress, reduce cellular ALT AST secretion, lower MDA levels, increase GSH-Px viability. Regulation metabolism involves inhibiting synthesis pathway activating expression proteins related triglyceride catabolic fatty oxidation pathways. contributes regulating provides new insights into alleviating fat theoretical basis for exploring protein regulation metabolism.

Language: Английский

Citations

1
Hepatoprotective, Lipid-Lowering and Antioxidant Effects of Mangaba Powder (Hancornia speciosa) Administered to Rats Fed a High-Fat Diet DOI Creative Commons

Bernadete de Lourdes de Araújo Silva,

Margarida Angélica da Silva Vasconcelos, Kamila Sabino Batista

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3773 - 3773

Published: Nov. 25, 2024

The aim of this study was to evaluate the potential effects administering mangaba powder on liver function and somatic, oxidative lipid metabolism parameters in rats fed a high-fat diet. Prepared has important amounts phenolic compounds, vitamin C, dietary fiber oligosaccharides. A total 32 adult Wistar were initially randomized into two groups for biological assay: normal-fat (NF, n = 16) (HF, diets 21 days. These subsequently subdivided four groups: NF (n 8), HF diet with administration (NFMG, 8) (HFMG, 8). treatment (400 mg/kg) lasted an additional 28 Compared rats, HFMG showed 8% reduction body mass index. Treatment reduced serum cholesterol by 18%, as well hepatic deposition triacylglycerides 26% 25%, addition increasing bile acid synthesis 77% organ. Mangaba consumption attenuated degree steatosis, peroxidation increased antioxidant capacity rats. results show that had lipid-lowering, hepatoprotective effects, especially which may be associated additive synergistic action between bioactive compounds present product.

Language: Английский

Citations

1