Causal Relationship Between Gluten-Free Diet and Autoimmune-Related Disease Risk: A Comprehensive Mendelian Randomization Study DOI Creative Commons
Yi Peng, Chenxi Liu, Wei Liu

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 22(2), P. 432 - 440

Published: Dec. 31, 2024

While the gluten-free diet (GFD) is primarily used to treat celiac disease (CD), recent research suggests it may also offer benefits for autoimmune-related diseases (ARDs), though findings remain inconsistent.This study aimed investigate potential protective effect of a GFD against ARDs by Mendelian Randomization (MR) analysis.Utilizing data from over 500,000 samples UK Biobank and other publicly available genome-wide association studies (GWAS), MR analysis revealed significant negative causal relationship between risk developing rheumatoid arthritis (RA) (OR = 0.782, 95% CI [0.727-0.841],p < 0.001).Mediation identified immune cells such as CD14+ CD16+ monocyte absolute count (mediating 2.441% effect), percentage (2.346%), CD20 on IgD+ CD38^dim B (3.119%) mediators in RA.These suggest that help reduce RA modulating specific cell populations.However, further necessary clarify exact mechanisms underlying these associations.

Language: Английский

Causal Relationship Between Gluten-Free Diet and Autoimmune-Related Disease Risk: A Comprehensive Mendelian Randomization Study DOI Creative Commons
Yi Peng, Chenxi Liu, Wei Liu

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 22(2), P. 432 - 440

Published: Dec. 31, 2024

While the gluten-free diet (GFD) is primarily used to treat celiac disease (CD), recent research suggests it may also offer benefits for autoimmune-related diseases (ARDs), though findings remain inconsistent.This study aimed investigate potential protective effect of a GFD against ARDs by Mendelian Randomization (MR) analysis.Utilizing data from over 500,000 samples UK Biobank and other publicly available genome-wide association studies (GWAS), MR analysis revealed significant negative causal relationship between risk developing rheumatoid arthritis (RA) (OR = 0.782, 95% CI [0.727-0.841],p < 0.001).Mediation identified immune cells such as CD14+ CD16+ monocyte absolute count (mediating 2.441% effect), percentage (2.346%), CD20 on IgD+ CD38^dim B (3.119%) mediators in RA.These suggest that help reduce RA modulating specific cell populations.However, further necessary clarify exact mechanisms underlying these associations.

Language: Английский

Citations

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