Effects of Saffron Supplementation on Glycolipid Metabolism and Blood Pressure in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

ABSTRACT Saffron is a traditional herbal medicine used to treat conditions associated with metabolic syndrome (MetS). However, the conclusions of relevant clinical studies have been inconsistent. This study aimed assess impact saffron supplementation on metabolism glycolipids and blood pressure in individuals MetS related disorders. Web Science, PubMed, Cochrane Library, Scopus, Embase were comprehensively searched for investigating disorders up February 2024. Stata 17.0 was conduct Meta‐analysis. Twenty‐five randomized controlled trials (RCTs) included this study, involving 1486 participants conditions. Compared placebo, triggered significant reductions fasting glucose (FBG) (WMD: −6.67 mg/dL; 95% CI: −10.55, −2.78; p = 0.001; I 2 50.0%), glycosylated hemoglobin A1c (HbA1c) −0.25%; −0.35, −0.14; < 0.0%), total cholesterol (TC) −4.77 −8.83, −0.71; 0.021; 31.8%), systolic (SBP) −1.15 mmHg; −1.66, −0.64; 41.8%), diastolic (DBP) −1.61 −1.88, −1.34; 7.0%). no changes observed homeostatic model assessment insulin resistance (HOMA‐IR), triglyceride (TG), low‐density lipoprotein (LDL‐C), high‐density (HDL‐C), body mass index (BMI), waist circumference (WC). has an improving effect FBG, HbA1c, TC, DBP, SBP patients Nonetheless, additional high‐quality RCTs diverse ethnic populations are necessary validate effect.

Language: Английский

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Sustainability and role of plant-based diets in chronic kidney disease prevention and treatment

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 31, 2025

Chronic kidney disease (CKD) affects 10% of the world's population (namely, 800 million people) and an increase in CKD prevalence has been observed over years. This phenomenon developed countries is related to spread chronic degenerative non-communicable diseases (CDNCDs), such as diabetes mellitus, arterial hypertension, obesity, etc., while low-income middle-income countries, attributable not only CDNCDs, but also infection conditions (like HIV, hepatitis, etc.). Another important difference lies age onset CKD, which about 20 years lower developing compared ones. Therefore, becoming a public health problem, requiring preventive treatment strategies counteract its slow progression. Moreover, healthcare costs for management progresses. In this regard, approach prevent reduce progression involves pharmacological nutritional treatments Mediterranean Diet, MedRen diet, Flexitarian Vegetarian Diet Plant-dominant Low Protein Diet) order improve patients' quality life and, at same time, promote environmental sustainability. Recent studies have highlighted benefits these diets individuals, environment. particular, plant-based increasingly gained role prevention diseases, including CKD. fact, recent scientific how greater adherence predominantly diets, associated with risk slowing With regard sustainability, it known our food choices influence climate crisis, since sector contributes 25% greenhouse gas emissions. consumption animal proteins replace them are key sustainability health, supported by European policies. context, industries starting offer products that similar characteristics, both sensorial nutritional, those origin. innovation, presents difficulties due perception taste organoleptic appearance products. An additional challenge concerns resistance traditional industry lack awareness consumer. The paradigm shift dictated obtained Life cycle assessment land footprint, carbon footprint blue water origin pointed out impact former. conclusion, adoption sustainable models will down positively impacting on human planet, significantly reducing resources National Health Systems, they absorb up 70%-80% costs.

Language: Английский

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Recycling Agricultural Waste: Sustainable Solutions for Enhancing Livestock Nutrition

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(3)

Published: March 29, 2025

ABSTRACT The increasing demand for sustainable agricultural practices prompts a reevaluation of feeding strategies in ruminant nutrition. Agricultural waste, often viewed as by‐product (BP), presents promising opportunity to enhance the sustainability livestock production systems. This review explores potential incorporating various BPs into diets. Utilizing these reduces environmental impact farming and contributes circular economy by recycling nutrients back food system. nutritional composition wastes varies widely, their inclusion diets improves feed efficiency, animal performance overall health. Research indicates that specific treatments, such fermentation ensiling, digestibility nutrient availability materials. Moreover, waste nutrition leads financial benefits farmers reducing reliance on conventional sources. However, key challenges remain, particularly need further research optimize rates address anti‐nutritional factors found some wastes. Notably, adding materials results 10%–30% reductions costs improvements 5%–20% metrics, weight gain milk production. These findings highlight economic utilizing practices. emphasizes necessity developing innovative leverage calling interdisciplinary approaches combine nutrition, agronomy science. By adopting practices, sector security while minimizing its ecological footprint. Future focuses processing techniques, effective management factors, assessing long‐term impacts health productivity. Additionally, examining aspects commonly used BPs, pomegranate, grape, pistachio, saffron, raisin, olive tomato, is essential fully understanding guiding development targeted strategies.

Language: Английский

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Revitalizing Marginal Areas of Basilicata (Southern Italy) with Saffron: A Strategy Approach Mixing Alternative Cultivation System and Land Suitability Analysis

Land, Journal Year: 2025, Volume and Issue: 14(4), P. 902 - 902

Published: April 19, 2025

The abandonment of farmland in Europe is a significant issue due to its environmental, socio-economic, and landscape consequences. This tendency mainly impacts marginal inner areas, located far from large urban districts, because biophysical and/or socio-economic factors. Although European national regulations try turn the fragility these territories into an opportunity for sustainable development, many especially southern Europe, continue suffer disparities. For this reason, it necessary consider regional district-wide initiatives that can economically revitalize areas while safeguarding their natural capital. Alternative cropping systems, capable optimizing quality some food crops, play essential role economic development populations living areas. These represented by inland zones often abandoned difficulty applying mechanized agriculture, represent rediscover profitable practices. Among high-value saffron (Crocus sativus L.), “red gold” “king spices”, stands out potential. Indeed, thanks use tuff tubs, more eco-sustainable choice compared plastic pots already mentioned literature, possible improve spice. Furthermore, Crocus L. not only lends itself multiple uses but also represents valid supplement agricultural income. made high profitability beneficial properties human health, offering way diversify production with positive social impacts. It known market Italy suffers competition developing countries (Iran, Morocco, India) producing at lower costs than countries, cost labor. Therefore, study seeks identify be recovered valorized through cultivation system potential enhance spice, making unique resilient competition. Specifically, paper organized on dual scale investigation: (a) local level demonstrate economic-ecological feasibility adoption alternative farming technique experimental site Tricarico (Basilicata—Southern Italy, 40°37′ N, 16°09′ E; 472 m. a.s.l.) that, although fertile, suitable systems; (b) spatially explicit land suitability analysis indicate location where export cultivation. final map, obtained combining geo-environmental variables, considered precious tool support policymakers farmers foster broad strategy founded new crop management systems. agroecological could optimize resources perspective increasing productivity

Language: Английский

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Influence of Solvent Polarity on Crocin Content and Surface Properties of Saffron (Crocus sativus L.) Extracts

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5144 - 5144

Published: Oct. 31, 2024

The saffron composition is being widely studied for authenticity and traceability, but very few works have been carried out to investigate the relationship between chemical physico-chemical properties of solutes their technological functionality in colloidal systems. This study aims at evaluating surface extracts obtained using solvents different polarities achieve with compositions terms pattern content polar medium polarity crocins. air-water was evaluated alone presence Tween 20 surfactant-extract ratios. Saffron were able decrease tension aqueous phase, indicating surface-active compounds. In mixed extract-Tween systems, competitive adsorption interface occurred when surfactant present a low concentration, while concentrations higher than CMC, hindered extract results highlight interesting applications To better exploit use design development formulated foods, nutraceutics pharma products, further studies are needed unravel corresponding activity.

Language: Английский

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The Possible Role of Plant-Based Bars Consumption in CKD Geriatric Patients

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1689 - 1689

Published: Dec. 14, 2024

Background: Chronic kidney disease (CKD) geriatric patients experience a premature aging process, compared with the general population of same age and sex. The uremic milieu is capable enhancing oxidative stress (OS) microinflammation, leading to pro-aging mechanism an increased protein catabolism. Moreover, cognitive disorders are observed. Objectives: aim this pilot study was evaluate possible beneficial effects on body composition, functions, inflammatory state OS CKD–geriatric induced by consumption two different plant-based bars (PBBs). Methods: A total 20 male (mean 73 ± 7 years) 9 female 71 4 were enrolled, divided as follows: 19 in PBBs group (that consumed both bars) 10 control group. They monitored for 12 weeks. presented moderate caloric value enriched waste by-products wine olive oil supply chains organic saffron. Results Conclusions: At end study, group, showed improvement their detected bioimpedance analysis ultrasound examination, function, revealed mini-mental examination. In we also observed reduction, through free oxygen radical test.

Language: Английский

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Doğum Şekli ve Doğum Korkusuna Etki Eden Faktörler

Özgür Yayınları eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 30, 2024

Doğum şekli; vajinal doğum, yardımlı doğum ve sezaryen şeklinde sıralanmaktadır. Anne bebek için en güvenilir tercih normal olarak kabul edilmesine rağmen gün geçtikçe artan oranları dikkat çekmektedir. Sezaryen nedenleri arasında tıbbi nedenlerin dışında konusunda güvenlik endişesi, obstetrik travma, öyküsü sık karşımıza çıkan korkusu bulunmaktadır. Her anne eşsiz bir deneyim adlandırılsa da çoğunlukla korku barındırmaktadır. Şiddetli tokofobi adlandırılmakta olup gebelik, sonrası süreçte olumsuz sonuçlara sebep olmaktadır. şekli tercihi yönetiminde eş refakatçi desteği, prekonsepsiyonel dönemden başlayarak sağlık profesyonellerinden kanıt temelli eğitim alınması, okuryazarlığının olumlu yönde etki sağladığı görülmektedir. Ebelik desteği ile adaylarının baş etme sonucunda doğumu oranlarının daha yüksek olduğu güçlü kanıtlarda Bu derlemenin amacı şekli, yönetimi ebelik bakımı güncel literatürün incelenmesidir.

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Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119273 - 119273

Published: Dec. 20, 2024

Language: Английский

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Presenting a fuzzy decision-making model for determining suitable locations for establishing agricultural waste collection centers based on sustainability and resilience dimensions.

Industrial Innovations Requirements and Strategies, Journal Year: 2024, Volume and Issue: 2(2), P. 194 - 211

Published: Sept. 20, 2024

Language: Английский

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