Association of 25-hydroxyvitamin D with all-cause and cardiovascular mortality among individuals with sarcopenia: evidence from the NHANES 2001–2006 DOI Creative Commons
Chen Fu, Zhongxin Zhu, Yijie Mao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 16, 2025

Background Sarcopenia, defined as the progressive decline in muscular mass and physical power, poses significant health risks, particularly among aging populations. Methods Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2001–2006, we employed multivariable Cox proportional hazards models to evaluate relationship between serum 25-hydroxyvitamin D [25(OH)D] concentration mortality outcomes, adjusting for multiple covariates. We additionally performed restricted cubic spline threshold analyses using both linear non-linear regression assess dose–response relationships explore continuous effects of 25(OH)D on outcomes. Stratified sensitivity were conducted strengthen reliability our findings. Results A total 1,666 participants diagnosed with sarcopenia included analysis. Our results indicated a association all-cause cardiovascular (CVD) mortality. Notably, revealed inflection points at 62.563 nmol/L 47.367 CVD mortality, suggesting plateau protective higher vitamin levels. Both stratified no interactions across different subgroups. Conclusion These findings emphasize importance maintaining adequate mitigate risk sarcopenic individuals. Further research is needed clarify underlying mechanisms establish optimal benefits.

Language: Английский

Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body DOI Creative Commons
Xingyu Liu, Yu Zhao,

Yanzhi Feng

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Age-related diseases have emerged as a global concern the population ages. Consequently, understanding underlying causes of aging and exploring potential anti-aging interventions is imperative. In females, ovaries serve principal organs responsible for ovulation production female hormones. The are related to infertility, menopause, associated menopausal syndromes, with menopause representing culmination ovarian aging. Current evidence indicates that may contribute dysfunction across multiple organ systems, including, but not limited to, cognitive impairment, osteoporosis, cardiovascular disease. Nevertheless, due widespread distribution sex hormone receptors throughout body, affects only these specific also influences broader spectrum age-related in women. Despite this, impact on overall has been largely neglected. This review provides thorough summary diseases, encompassing nervous, circulatory, locomotor, urinary, digestive, respiratory, endocrine systems. Additionally, we outlined prospective therapeutic approaches addressing both aim mitigating their impacts preserving women's fertility, physical health, psychological well-being.

Language: Английский

Citations

1
Mechanistic Insights into the Biological Effects and Antioxidant Activity of Walnut (Juglans regia L.) Ellagitannins: A Systematic Review DOI Creative Commons
Letiția Mateș, Roxana Banc,

Flaviu Andrei Zaharie

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 974 - 974

Published: Aug. 10, 2024

Walnuts (

Language: Английский

Citations

5
60 is the new 40: preparing for better bone health in later life DOI Creative Commons
Leo D. Westbury,

Kamran Gaba,

Gregorio Bevilacqua

et al.

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: March 19, 2025

In this study we evaluated associations between nutritional factors, including calcium supplementation, and outcomes of fracture cardiovascular mortality. We chose to report both as an illustration the importance factors in midlife heart disease may be more impactful for supporting behavior change strategies, particularly men. This was nested Hertfordshire Cohort Study, a community dwelling cohort 2,997 adults (47% women) who were extensively phenotyped at baseline followed up 20 years using Hospital Episode Statistics linkage. Mean (SD) age 65.7 (2.9) among men 66.6 (2.7) women. There some evidence that better diet quality related reduced risk hip after adjustment sex (hazard ratio (95% CI): 0.82 (0.67, 1.00) per SD higher prudent score). Dietary intake not associated with either any or fracture. Taking supplements increased fracture, possibly because reverse causality will typically prescribed following osteoporotic A dietary protective against cardiovascular-related mortality, while taking led no excess (p = 0.870). Higher scores, indicative quality, other beneficial lifestyle choices such odds ever smoking [odds CI) score: 0.69 (0.63,0.74)], physical activity (SD difference score 0.06 (0.02,0.10)). have demonstrated commonality adverse clinical older adults. These data might used strategies aimed improve nutrition linked midlife.

Language: Английский

Citations

0
The association of vitamin deficiency with depression risk in late-life depression: a review DOI Creative Commons
Yao Gao, Xiaona Song, Z. G. Wen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Late-life depression (LLD), a growing public health challenge in aging societies, profoundly impacts physical and mental by exacerbating cognitive decline, functional disability, comorbid chronic diseases. Emerging research highlights vitamin supplementation as promising adjunctive therapy for LLD, targeting its multifactorial pathogenesis involving mitochondrial dysfunction, neuroinflammation, oxidative stress. Specific vitamins, including B-complex vitamins (B1, B6, B9, B12), D, antioxidants (C, E), demonstrate therapeutic potential through mechanisms ranging from neurotransmitter regulation to function enhancement. For instance, D modulates serotonin synthesis calcium signaling, while B mitigate homocysteine-mediated neurotoxicity support energy metabolism. Antioxidants counteract neural damage linked depressive severity. Clinical studies reveal that deficiency (<20 ng/mL) correlates with elevated risk, combined B-vitamin shows symptom alleviation nutritionally deficient subgroups. However, evidence remains heterogeneous due variability dosing protocols, bioavailability, population-specific factors like comorbidities. Despite evidence, critical gaps persist regarding optimal dosages, bioavailability variations, long-term outcomes elderly populations. This review synthesizes current on vitamin-mediated cellular pathways LLD management, evaluates clinical efficacy across interventions, proposes personalized nutritional strategies optimize outcomes. By integrating mechanistic insights data, this analysis aims guide evidence-based protocols within geriatric care frameworks.

Language: Английский

Citations

0
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial DOI Creative Commons
Samira Rastgoo, Katayoun Pourvali, Seyed Ahmad Raeissadat

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Background Immunosenescence is an important factor in the impaired immune response older adults and plays a significant role development of biological aging. Targeting immunosenescence could present novel pharmacological approach to mitigating aging age-related diseases. We aimed investigate effect N-acetylcysteine (NAC) vitamin D (Vit-D) on senescence peripheral blood mononuclear cells (PBMCs). Method This randomized clinical trial was conducted with Vit-D deficiency. Eligible participants were randomly assigned one four groups receive either (A) 1000 IU daily (D1) (B), plus 600 mg NAC (D1N) (C), 5000 (D5), or (D) (D5N) for 8 weeks. Senescence-associated beta-galactosidase (SA-β-gal) staining, expression senescence-related genes, serum inflammatory factors measured at baseline after Results After intervention, supplementation D5N D5 significantly downregulated p16 , interleukin-6 ( IL-6 ), tumor necrosis factor-α TNF-α ) decreased SA-β-gal activity compared D1 group. Additionally, co-administration transcripts PBMCs alone. No differences observed between IL-6, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) intervention. Conclusions The loading dose attenuates adults. However, both standard doses further enhances these beneficial effects. Clinical registration https://irct.behdasht.gov.ir identifier IRCT20230508058120N1.

Language: Английский

Citations

0
The effect of menopause on the associations between dietary intake and the 20-year incidence of cardiovascular disease in women: the ATTICA cohort study (2002−2022) DOI
Evangelia G. Sigala, Christina Chrysohoou, Fotios Barkas

et al.

Maturitas, Journal Year: 2025, Volume and Issue: 198, P. 108600 - 108600

Published: May 13, 2025

Language: Английский

Citations

0
Association of 25-hydroxyvitamin D with all-cause and cardiovascular mortality among individuals with sarcopenia: evidence from the NHANES 2001–2006 DOI Creative Commons
Chen Fu, Zhongxin Zhu, Yijie Mao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 16, 2025

Background Sarcopenia, defined as the progressive decline in muscular mass and physical power, poses significant health risks, particularly among aging populations. Methods Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2001–2006, we employed multivariable Cox proportional hazards models to evaluate relationship between serum 25-hydroxyvitamin D [25(OH)D] concentration mortality outcomes, adjusting for multiple covariates. We additionally performed restricted cubic spline threshold analyses using both linear non-linear regression assess dose–response relationships explore continuous effects of 25(OH)D on outcomes. Stratified sensitivity were conducted strengthen reliability our findings. Results A total 1,666 participants diagnosed with sarcopenia included analysis. Our results indicated a association all-cause cardiovascular (CVD) mortality. Notably, revealed inflection points at 62.563 nmol/L 47.367 CVD mortality, suggesting plateau protective higher vitamin levels. Both stratified no interactions across different subgroups. Conclusion These findings emphasize importance maintaining adequate mitigate risk sarcopenic individuals. Further research is needed clarify underlying mechanisms establish optimal benefits.

Language: Английский

Citations

0