Mechanometabolic Regulation in Cancer Progression: Lessons from Fibrotic Remodeling DOI Creative Commons
Chen‐Yueh Wen, Po-Hung Chen, Renin Chang

et al.

International Journal of Biological Sciences, Journal Year: 2025, Volume and Issue: 21(6), P. 2672 - 2675

Published: March 31, 2025

Language: Английский

Glucose metabolism impairment in major depressive disorder DOI Creative Commons

Fanhao Meng,

Jing Wang, Long Wang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111191 - 111191

Published: Jan. 7, 2025

Major depressive disorder (MDD) is a common mental with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains unclear. Patients MDD experience systemic localized impairments in glucose metabolism throughout the disease course, disrupting various processes such as uptake, glycoprotein transport, glycolysis, tricarboxylic acid cycle (TCA), oxidative phosphorylation (OXPHOS). These may result from mechanisms including insulin resistance, hyperglycemia-induced damage, stress, astrocyte abnormalities, mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, functional structural damage reward networks. mechanical changes contribute of severely interfere prognosis. Herein, we summarized impairment pathophysiological patients MDD. In addition, briefly discussed potential pharmacological interventions for alleviate MDD, glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, pioglitazone, encourage development new therapeutics.

Language: Английский

Citations

1
The characteristics, influence factors, and regulatory strategies of growth retardation in ruminants: a review DOI Creative Commons
Tao Li,

B. Raja,

Jie Liao

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Growth retardation represents a main barrier to affect the productivity and efficiency of ruminants production, which is characterized by low growth rate, disparity between skeletal physiological maturation, gastrointestinal dysfunction reduced reproductive performance. This review provides concise overview in ruminants, summarizes key factors that influence their development, including genetics, nutrition, microbiota environment. Also, this emphasizes central role nutritional management as well regulatory mechanisms involved processes. In addition, recent advances these aspects are discussed form an integrative framework aimed at improving function ruminants. comprehensive perspective for understanding complex mechanism puts forward theoretical basis optimizing production industry importance multidisciplinary collaboration provide reference advancing systematic research on development

Language: Английский

Citations

1
Emerging Role of Extracellular pH in Tumor Microenvironment as a Therapeutic Target for Cancer Immunotherapy DOI Creative Commons
Md. Ataur Rahman,

Mahesh Kumar Yadab,

Meser M. Ali

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1924 - 1924

Published: Nov. 20, 2024

Identifying definitive biomarkers that predict clinical response and resistance to immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in the tumor microenvironment (TME), which significantly impairs immune cell function contributes failure. However, acidic conditions TME disrupt interaction between cancer cells, driving tumor-infiltrating T cells NK into an inactivated, anergic state. Simultaneously, promotes recruitment activation of immunosuppressive such as myeloid-derived suppressor regulatory (Tregs). Notably, acidity enhances exosome release from Tregs, further amplifying immunosuppression. Tumor thus acts "protective shield," neutralizing anti-tumor responses transforming pro-tumor allies. Therefore, targeting lactate metabolism has emerged promising strategy overcome this barrier, with approaches including buffer agents neutralize pH inhibitors block production or transport, thereby restoring efficacy TME. Recent discoveries have identified genes involved (pHe) regulation, presenting new therapeutic targets. Moreover, ongoing research aims elucidate molecular mechanisms acidification develop treatments modulate levels enhance outcomes. Additionally, future studies are crucial validate safety pHe-targeted therapies patients. Thus, review explores regulation pHe its potential role improving immunotherapy.

Language: Английский

Citations

8
SUMOylated GLUT1 inhibited the glycometabolism disorder in chondroctyes during osteoarthritis DOI Creative Commons
Liwei Xiong

Glycoconjugate Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

0
Repercussions of modulation of gestational resistance training intensity on placental cell composition and nutrient transporter expression DOI
Thaynan Raquel dos Prazeres Oliveira,

Débora Priscila Lima-Oliveira,

Maira Beatriz Matos de Paula

et al.

Placenta, Journal Year: 2025, Volume and Issue: 161, P. 55 - 64

Published: Feb. 3, 2025

Language: Английский

Citations

0
Mechanometabolic Regulation in Cancer Progression: Lessons from Fibrotic Remodeling DOI Creative Commons
Chen‐Yueh Wen, Po-Hung Chen, Renin Chang

et al.

International Journal of Biological Sciences, Journal Year: 2025, Volume and Issue: 21(6), P. 2672 - 2675

Published: March 31, 2025

Language: Английский

Citations

0