Advancing Obesity Management: the Very Low-Energy Ketogenic therapy (VLEKT) as an Evolution of the “Traditional” Ketogenic Diet
Current Obesity Reports,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: April 3, 2025
This
narrative
review
comprehensively
analyzes
VLEKT
as
an
advanced
nutritional
strategy
for
obesity
management.
The
focus
is
on
the
beneficial
effects
key
disease
organs,
such
adipose
tissue
and
liver,
well
modulation
of
intestinal
permeability
its
fundamental
role
in
influencing
gut
microbiota
inflammatory
pathways.
impact
obesity-related
comorbidities,
including
metabolic
syndrome,
cardiovascular
disease,
endocrine
disorders,
dysfunction-associated
steatotic
liver
(MASLD),
neurological
kidney
alterations,
also
investigated.
Moreover,
to
assess
wider
application
treatment,
combination
ketogenic
regimes
with
additional
strategies
physical
activity,
bariatric
surgery,
digital
health
technologies
examined.
Despite
promising
clinical
results,
adherence
potential
deficiencies
require
careful
follow-up
individualized
programming
monitored
by
specialists.
Future
research
should
elucidating
molecular
mechanisms
underlying
physiological
systems,
long-term
safety.
Nevertheless,
innovative
approach
offering
a
target-oriented
highly
effective
people
fighting
against
overweight
associated
medical
complications.
Obesity
multifactorial
chronic
numerous
comorbidities;
given
increasing
prevalence,
personalized
intervention
are
crucial
inhibit
"obesity
pandemic"
according
"food
re-educational"
protocol.
Among
dietary
interventions,
diet
(KD)
has
attracted
attention
effectiveness
weight
management
benefits.
A
variant,
very
low-calorie
(VLCKD),
more
recently
defined
low-energy
(VLEKD),
combines
benefits
ketosis
substantial
calorie
restriction,
improving
overall
health.
Language: Английский
An 8-Week Very Low-Calorie Ketogenic Diet (VLCKD) Alters the Landscape of Obese-Derived Small Extracellular Vesicles (sEVs), Redefining Hepatic Cell Phenotypes
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4189 - 4189
Published: Dec. 4, 2024
Very
low-calorie
ketogenic
diets
(VLCKD)
are
an
effective
weight-loss
strategy
for
obese
individuals,
reducing
risks
of
liver
conditions
such
as
non-alcoholic
steatohepatitis
and
fibrosis.
Small
extracellular
vesicles
(sEVs)
implicated
in
fibrosis
by
influencing
hepatic
cell
phenotypes
contributing
to
damage.
This
study
investigates
sEVs
derived
from
serum
60
adults
categorized
into
low
risk
(LR)
intermediate/high
(IHR)
groups
based
on
FibroScan
elastography
(FIB
E
scores,
limit
value
8
kPa)
all
participants
underwent
8-week
VLCKD
intervention.
Language: Английский