L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(4), P. 665 - 665
Published: Feb. 13, 2025
This
narrative
review
provides
an
analysis
of
the
role
nitric
oxide
(NO)
and
its
precursors,
particularly
L-arginine,
in
vascular
regulation
health,
with
emphasis
on
findings
from
our
experimental
research
animal
models.
NO
serves
as
a
critical
mediator
function,
contributing
to
vasodilation,
blood
flow,
prevention
thrombosis.
As
primary
precursor
NO,
L-arginine
is
essential
for
maintaining
endothelial
integrity,
modulating
mitochondrial
reducing
oxidative
damage.
synthesises
data
contextualises
these
within
physiological
challenges
faced
by
donors,
such
repeated
donation
associated
stress.
It
examines
effects
supplementation
respiration,
lipid
peroxidation,
microsomal
oxidation
different
conditions,
including
differences
age,
gender,
dietary
interventions.
The
mechanisms
which
enhances
production,
improves
elasticity,
alleviates
dysfunction
caused
reduced
bioavailability
are
also
investigated.
By
integrating
insights
existing
literature,
this
perspective
potential
address
specific
needs
donors.
highlights
importance
personalised
nutritional
approaches
enhancing
donor
recovery
resilience.
In
addition,
assesses
wider
implications
mitigating
stress
preserving
function.
interplay
between
bioavailability,
factors,
adaptation
donors
highlighted,
along
identification
current
knowledge
gaps
recommendations
future
research.
presenting
both
original
evidence
synthesis
article
therapeutic
promoting
health
context
donation.
Language: Английский
Adaptogens in Long-Lasting Brain Fatigue: An Insight from Systems Biology and Network Pharmacology
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(2), P. 261 - 261
Published: Feb. 15, 2025
Long-lasting
brain
fatigue
is
a
consequence
of
stroke
or
traumatic
injury
associated
with
emotional,
psychological,
and
physical
overload,
distress
in
hypertension,
atherosclerosis,
viral
infection,
aging-related
chronic
low-grade
inflammatory
disorders.
The
pathogenesis
linked
to
disrupted
neurotransmission,
the
glutamate-glutamine
cycle
imbalance,
glucose
metabolism,
ATP
energy
supply,
which
are
multiple
molecular
targets
signaling
pathways
neuroendocrine-immune
blood
circulation
systems.
Regeneration
damaged
tissue
long-lasting
multistage
process,
including
spontaneously
regulating
hypothalamus-pituitary
(HPA)
axis-controlled
anabolic-catabolic
homeostasis
recover
harmonized
sympathoadrenal
system
(SAS)-mediated
function,
deregulated
gene
expression
rehabilitation.
driving
mechanism
spontaneous
recovery
regeneration
cross-talk
mediators
neuronal,
microglia,
immunocompetent,
endothelial
cells
collectively
involved
neurogenesis
angiogenesis,
plant
adaptogens
can
target.
Adaptogens
small
molecules
origin
that
increase
adaptability
organisms
stress
by
interaction
HPA
axis
SAS
(neuroendocrine-immune
cardiovascular
complex),
targeting
adaptive
GPCR
pathways.
Two
major
groups
comprise
(i)
phenolic
phenethyl
phenylpropanoid
derivatives
(ii)
tetracyclic
pentacyclic
glycosides,
whose
chemical
structure
be
distinguished
as
related
correspondingly
monoamine
neurotransmitters
(epinephrine,
norepinephrine,
dopamine)
steroid
hormones
(cortisol,
testosterone,
estradiol).
In
this
narrative
review,
we
discuss
multitarget
integrated
pharmacological
activity
botanical
ischemic
stroke,
fatigue;
time-dependent
dual
response
physiological
regulatory
systems
support
overload;
(iii)
dose-dependent
reversal
(hormetic)
effect
adaptogens.
This
review
shows
adaptogenic
concept
cannot
reduced
rectified
various
effects
on
selected
specific
modes
action
without
estimating
their
interactions
within
networks
complex
that,
turn,
regulates
other
(cardiovascular,
gastrointestinal,
reproductive
systems)
due
numerous
intra-
extracellular
communications
feedback
regulations.
These
result
polyvalent
pleiotropic
adaptogens,
essential
for
characterizing
distinct
types
botanicals.
They
trigger
defense
leads
extension
limits
resilience
inducing
mental
For
first
time,
justifies
potential
particularly
hybrid
preparation
(BHP)
Arctic
Root
Ashwagandha,
providing
rationale
use
individuals
experiencing
fatigue.
provided
insight
into
future
research
network
pharmacology
preventing
rehabilitating
following
trauma,
infections.
Language: Английский
Investigation of the Effect of Topinambur Extract on Cholesterol Levels
Alina Sergeevna Shahova,
No information about this author
Evgenii Yurevich Chmutov,
No information about this author
Amina Ramazanovna Shkhanokova
No information about this author
et al.
Archives of Pharmacy Practice,
Journal Year:
2024,
Volume and Issue:
15(4), P. 53 - 57
Published: Jan. 1, 2024
Language: Английский
The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13338 - 13338
Published: Dec. 12, 2024
Resveratrol,
a
naturally
occurring
polyphenolic
compound
found
in
various
plants,
has
been
extensively
studied
for
its
broad
spectrum
of
beneficial
biological
effects.
These
encompass
potent
antioxidant
properties,
anti-inflammatory
activities,
anti-aging
capabilities,
cardioprotective
functions,
and
neuroprotective
potential.
The
diverse
actions
resveratrol
extend
beyond
these
well-established
properties.
It
also
exerts
significant
impact
on
metabolic
processes
bioavailability,
critically,
it
demonstrates
the
ability
to
effectively
traverse
blood–brain
barrier.
This
capacity
penetrate
central
nervous
system
renders
promising
therapeutic
agent
management
malignancies,
as
shown
inhibit
tumor
cell
proliferation,
induce
apoptosis,
modulate
key
signaling
cascades,
such
PI3K/Akt,
JAK/STAT,
NF-kB.
multifaceted
nature
resveratrol’s
effects,
including
influence
physiological
processes,
underscores
potential
valuable
option
treatment
tumors.
Language: Английский