Global Status, Recent Trends, and Knowledge Mapping of Olive Bioactivity Research Through Bibliometric Analysis (2000–2024)

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1349 - 1349

Published: April 14, 2025

Over the past two decades, both academic and industrial interest in olive bioactive compounds has grown significantly due to their remarkable health benefits, such as antioxidant, anti-inflammatory, cardioprotective properties. These compounds, found fruit leaves, have become a central focus research on functional foods nutraceuticals. A comprehensive bibliometric analysis of scientific publications from 2000 2024 highlights notable increase this field, with 2228 documents published high-impact journals an estimated annual growth rate 0.2694 year−1, particularly last decade. This surge reflects growing recognition compounds’ potential promoting human through nutritional therapeutic interventions, role expanding nutraceutical industry. is further reaffirmed by patent analysis, which shows significant rise filings related compounds. The also examined nearly 6000 keywords identify most influential domains, pinpoint knowledge gaps, reveal important olives preventing various diseases.

Language: Английский

Screening and Isolating Acetylcholinesterase Inhibitors from Olea europaea L. Fruit Using Ultrafiltration–Liquid Chromatography Coupled with High-Speed Counter-Current Chromatography

Separations, Journal Year: 2025, Volume and Issue: 12(4), P. 96 - 96

Published: April 12, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative condition and one of the most prevalent types dementia in older adults. Currently, primary drugs used to treat AD are acetylcholinesterase (AChE) inhibitors. The development natural substances has become research hotspot due high number adverse effects synthetic drugs. In this study, new assay based on ultrafiltration–liquid chromatography–high-speed counter-current chromatography (UF-HPLC-HSCCC) was developed for rapid screening identification AChE inhibitors from Olea europaea L. fruit. research, we screened isolated two O. fruit extracts, identified by EI-MS NMR as secologanoside oleuroside-11-methyl ester. These compounds were first time found possess inhibitory activity using an vitro inhibition molecular docking. IC50 values 0.76 ± 0.04 mM 1.08 0.05 mM. results demonstrated that showed better than ester, suggesting compound promising inhibitor. At same time, combination UF-HPLC- HSCCC provides powerful tool isolating complex samples.

Language: Английский