Adipocytokine Protein Expression from Visceral Fat Differs Significantly Based on Diet, Sex, and Age in C3H/HeJ Mice Fed Long-Term, High-Fat Diets, ± Ammonium-Hydroxide-Supplemented Dietary Protein DOI Creative Commons

Caleb Boren,

Benjamin Barr,

Noshin Mubtasim

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 218 - 218

Published: March 23, 2025

(1) Background: Overconsumption of processed meats, fats, and carbohydrates drives the obesity epidemic in USA. Associated with this are increases metabolic diseases, such as type 2 diabetes, cardiovascular disease, cancer. In study, protein levels adipocytokines isolated from visceral fat mice fed high-fat diets proteins modified through ammonium supplementation were analyzed to determine changes that occur a result dietary source its modification based on age or sex. (2) Methods: Male female C3H/HeJ randomized into six customized diets—Group 1: CCN = Control Chow (CC) + Ammonium Hydroxide Enhancement (AHE); Group 2: CC Chow; 3: HFBN High Fat (HF) AHE Dietary Beef; 4: HFB HF 5: HFCN Casein; 6: HFC Casein. Mice censored at six-month intervals, was collected for analysis. This study highlights sex- age-related cellular adipocytokine expression 12 18 months. (3) Results: When compared casein, dietary-beef-fed showed increased adiponectin, leptin, MCP-1. casein diets, high content correlated pro-inflammatory MCP-1, resistin, VEGF-A, TIMP-1. Sex-related differences observed MCP-1 levels. decreased Age-related VEGF-A. (4) Conclusions: Our results indicate plays critical role determining WAT. Furthermore, shows addition (beef casein), also impact relative both anti-inflammatory sex over time, leptin identified most frequently affected.

Language: Английский

Red Meat Amino Acids for Beginners: A Narrative Review DOI Open Access

Benjamin Barr,

Danielle E. Levitt, Lauren Gollahon

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 939 - 939

Published: March 7, 2025

Meat is a major source of dietary protein and fat across the globe. Red white meat are terms consumers use to refer types meat; however, these do not fully encompass range nutrients provided by sources. refers from mammalian skeletal muscle, while poultry. both provide wide nutritional components in context fatty acids, amino acids micronutrients. Importantly, it has been demonstrated that acid profiles differ between red as well different sources meat. complete meaning contains all essential (EAAs), addition, non-essential (NEAAs). also most abundant bioavailable heme-iron for muscle growth cardiovascular health. indicated contributor rising incidence metabolic disorders even colorectal cancer. However, important note consumption linked conditions, typically overconsumption associated with obesity other symptoms. Similarly, preparation key factor its link cancer some methods produce carcinogens others not. Finally, may be situationally more beneficial groups than others, particularly cases sex aging. For pregnant women, increases increase intake semi-essential elderly, better preserve mass compared

Language: Английский

Citations

0

Adipocytokine Protein Expression from Visceral Fat Differs Significantly Based on Diet, Sex, and Age in C3H/HeJ Mice Fed Long-Term, High-Fat Diets, ± Ammonium-Hydroxide-Supplemented Dietary Protein DOI Creative Commons

Caleb Boren,

Benjamin Barr,

Noshin Mubtasim

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 218 - 218

Published: March 23, 2025

(1) Background: Overconsumption of processed meats, fats, and carbohydrates drives the obesity epidemic in USA. Associated with this are increases metabolic diseases, such as type 2 diabetes, cardiovascular disease, cancer. In study, protein levels adipocytokines isolated from visceral fat mice fed high-fat diets proteins modified through ammonium supplementation were analyzed to determine changes that occur a result dietary source its modification based on age or sex. (2) Methods: Male female C3H/HeJ randomized into six customized diets—Group 1: CCN = Control Chow (CC) + Ammonium Hydroxide Enhancement (AHE); Group 2: CC Chow; 3: HFBN High Fat (HF) AHE Dietary Beef; 4: HFB HF 5: HFCN Casein; 6: HFC Casein. Mice censored at six-month intervals, was collected for analysis. This study highlights sex- age-related cellular adipocytokine expression 12 18 months. (3) Results: When compared casein, dietary-beef-fed showed increased adiponectin, leptin, MCP-1. casein diets, high content correlated pro-inflammatory MCP-1, resistin, VEGF-A, TIMP-1. Sex-related differences observed MCP-1 levels. decreased Age-related VEGF-A. (4) Conclusions: Our results indicate plays critical role determining WAT. Furthermore, shows addition (beef casein), also impact relative both anti-inflammatory sex over time, leptin identified most frequently affected.

Language: Английский

Citations

0