Sugar-Free but Not Risk-Free? Exploring Artificial Sweeteners and Cardiovascular Disease DOI

Lillian Huang,

Ellen N. Huhulea,

Esewi Aifuwa

et al.

Cardiology in Review, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

The consumption of artificial sweeteners has significantly increased globally, particularly as a substitute for sugar the management conditions such diabetes and obesity, which are significant risk factors cardiovascular disease. Despite their widespread use, health impacts remain contentious. Research suggested that certain may contribute to systemic inflammation, endothelial dysfunction, disruptions in gut microbiota, potentially altering glucose metabolism exacerbating metabolic obesity. However, other studies highlight potential benefits, weight control improved tolerance. Still, long-term safety sweeteners, with chronic consumption, remains uncertain. This literature review explores risks associated various focusing on 6 US Food Drug Administration–approved nonnutritive aspartame, sucralose, saccharin, acesulfame K, cyclamate, neotame, well nutritive polyols (erythritol, xylitol, sorbitol, maltitol). Ongoing research, including vitro, animal, clinical studies, aims clarify implications assess use across diverse populations.

Language: Английский

Sugar-Free but Not Risk-Free? Exploring Artificial Sweeteners and Cardiovascular Disease DOI

Lillian Huang,

Ellen N. Huhulea,

Esewi Aifuwa

et al.

Cardiology in Review, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

The consumption of artificial sweeteners has significantly increased globally, particularly as a substitute for sugar the management conditions such diabetes and obesity, which are significant risk factors cardiovascular disease. Despite their widespread use, health impacts remain contentious. Research suggested that certain may contribute to systemic inflammation, endothelial dysfunction, disruptions in gut microbiota, potentially altering glucose metabolism exacerbating metabolic obesity. However, other studies highlight potential benefits, weight control improved tolerance. Still, long-term safety sweeteners, with chronic consumption, remains uncertain. This literature review explores risks associated various focusing on 6 US Food Drug Administration–approved nonnutritive aspartame, sucralose, saccharin, acesulfame K, cyclamate, neotame, well nutritive polyols (erythritol, xylitol, sorbitol, maltitol). Ongoing research, including vitro, animal, clinical studies, aims clarify implications assess use across diverse populations.

Language: Английский

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