Is Multiwavelength Photobiomodulation Effective and Safe for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis
Kuo-Su Chen,
No information about this author
Helena Lee,
No information about this author
Hoi-Chun Chan
No information about this author
et al.
Ophthalmology and Therapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 16, 2025
This
systematic
review
and
meta-analysis
compares
the
complications
effects
of
photobiomodulation
(PBM)
therapy
with
sham
treatment
in
patients
age-related
macular
degeneration
(AMD).
AMD
is
a
leading
cause
visual
impairment
older
adults,
current
treatments
primarily
focusing
on
symptom
management.
PBM
emerging
as
potential
intervention
to
improve
clinical
anatomical
outcomes
AMD,
necessitating
comparative
analysis
determine
its
efficacy
safety.
A
search
was
conducted
across
PubMed/Medline,
Google
Scholar
Cochrane
Library
from
inception
January
13,
2025.
Randomised
controlled
trials
(RCTs)
meeting
predefined
inclusion
criteria
were
selected.
Meta-analysis
employed
random-effects
models.
The
risk
bias
included
studies
assessed
using
tools.
total
six
studies,
comprising
360
477
eyes,
focused
for
dry
AMD.
Five
eligible
meta-analysis.
Best-corrected
acuity
(BCVA)
showed
no
significant
improvement
(SMD
−
0.30,
95%
CI
0.85
0.26,
p
=
0.30),
high
heterogeneity
(I2
83%).
Macular
drusen
volume
also
change
0.08,
0.52
0.37,
0.74),
moderate
48%).
single
study
reported
effect
geographic
atrophy
0.28,
1.26
0.71,
0.58).
Central
subfield
thickness
0.11,
0.25
0.47,
0.58)
microperimetry
0.02,
0.48
0.44,
0.94)
changes.
adverse
events
indicated
statistically
increase
group
within
6
months
(RR
0.48,
0.29–0.82,
0.007),
while
overall
non-significant
1.04,
0.51–2.12,
0.91,
I2
78%).
Qualitative
suggested
that
might
enhance
quality
life
compared
treatment.
suggests
that,
date,
there
are
benefits
Further
long-term
needed
establish
relevance
safety
profile.
Language: Английский
Relationship Between Dietary Nutrient Intake and Autophagy—Related Genes in Obese Humans: A Narrative Review
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4003 - 4003
Published: Nov. 22, 2024
Obesity
is
one
of
the
world’s
major
public
health
challenges.
Its
pathogenesis
and
comorbid
metabolic
disorders
share
common
mechanisms,
such
as
mitochondrial
or
endoplasmic
reticulum
dysfunction
oxidative
stress,
gut
dysbiosis,
chronic
inflammation
altered
autophagy.
Numerous
pro-autophagy
dietary
interventions
are
being
investigated
for
their
potential
obesity-preventing
therapeutic
effects.
We
summarize
current
data
on
relationship
between
autophagy
obesity,
discuss
various
regulators
autophagy-related
genes
in
prevention
ultimate
treatment
obesity
humans,
available
scientific
databases
published
through
July
2024.
Lifestyle
modifications
(such
calorie
restriction,
intermittent
fasting,
physical
exercise),
including
following
a
diet
rich
flavonoids,
antioxidants,
specific
fatty
acids,
amino
acids
others,
have
shown
beneficial
role
induction
this
process.
The
activation
nutritional
tends
to
elicit
consistent
response,
characterized
by
certain
kinases
(including
AMPK,
IKK,
JNK1,
TAK1,
ULK1,
VPS34)
suppression
others
(like
mTORC1),
deacetylation
proteins,
alleviation
inhibitory
interactions
BECN1
members
Bcl-2
family.
Significant
health/translational
properties
many
nutrients
(nutraceuticals)
can
affect
disease
risk
mechanisms
that
include
inhibition
intervention
regulation
its
comorbidities
not
yet
clear,
especially
obese
individuals.
Language: Английский
Editorial: The Effect of Nutrients on Neurological Disorders
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4016 - 4016
Published: Nov. 23, 2024
The
prevalence
of
neurological
disorders
(NDs)
is
increasing,
with
great
cost
to
public
health
[...].
Language: Английский
Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma
Karina Zolotareva,
No information about this author
Polina A. Dotsenko,
No information about this author
N. L. Podkolodnyy
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12802 - 12802
Published: Nov. 28, 2024
Primary
open-angle
glaucoma
(POAG)
is
the
most
common
form
of
glaucoma.
This
condition
leads
to
optic
nerve
degeneration
and
eventually
blindness.
Tobacco
smoking,
alcohol
consumption,
fast-food
diets,
obesity,
heavy
weight
lifting,
high-intensity
physical
exercises,
many
other
bad
habits
are
lifestyle-related
risk
factors
for
POAG.
By
contrast,
moderate-intensity
aerobic
exercise
Mediterranean
diet
can
alleviate
In
this
work,
we
first
time
estimated
phylostratigraphic
age
indices
(PAIs)
all
153
POAG-related
human
genes
in
NCBI
Gene
Database.
allowed
us
separate
them
into
two
groups:
that
appeared
before
after
phylum
Chordata,
is,
ophthalmologically
speaking,
camera-type
eye
evolved.
Next,
genes’
promoters,
silico
predicted
3835
candidate
SNP
markers
significantly
change
TATA-binding
protein
(TBP)
affinity
these
promoters
and,
through
molecular
mechanism,
expression
levels
genes.
Finally,
verified
our
results
against
five
independent
web
services—PANTHER,
DAVID,
STRING,
MetaScape,
GeneMANIA—as
well
as
ClinVar
database.
It
was
concluded
POAG
likely
be
a
symptom
self-domestication
syndrome,
downside
being
civilized.
Language: Английский