The Impact of Green Tea Kombucha on the Intestinal Health, Gut Microbiota, and Serum Metabolome of Individuals with Excess Body Weight in a Weight Loss Intervention: A Randomized Controlled Trial DOI Creative Commons
Gabriela Macedo Fraiz, Dandara Baia Bonifácio, Udielle Vermelho Lacerda

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(22), P. 3635 - 3635

Published: Nov. 14, 2024

Green tea kombucha (GTK) has emerged as a promising probiotic fermented beverage. Few studies have investigated its effect on human health, mainly focusing intestinal microbiota composition, and metabolomics. The present study is pioneer in investigating the of GTK consumption individuals with excess body weight. This randomized controlled trial, lasting ten weeks, two groups placed under an energy-restricted diet: control (CG, n = 29), (KG, 30; 200 mL/d). Biological samples questionnaires were collected before after intervention. Microbiota analysis used amplification V4 region 16S rRNA. Serum untargeted metabolomics HPLC-TOF mass spectrometry. Intestinal permeability considered urine excretion lactulose mannitol, plasma zonulin, LPS-binding protein. After intervention, no differences related to found between groups, but only CG had increased fecal pH, lactulose/mannitol ratio, zonulin. In addition this, KG reported lower gastrointestinal symptoms motility compared CG, discriminant metabolites (e.g., diethyl malonate) strictly KG. did not significantly improve gut permeability. However, ameliorated positively influenced serum metabolome, which may contribute enhancing metabolic health

Language: Английский

The Impact of Green Tea Kombucha on the Intestinal Health, Gut Microbiota, and Serum Metabolome of Individuals with Excess Body Weight in a Weight Loss Intervention: A Randomized Controlled Trial DOI Creative Commons
Gabriela Macedo Fraiz, Dandara Baia Bonifácio, Udielle Vermelho Lacerda

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(22), P. 3635 - 3635

Published: Nov. 14, 2024

Green tea kombucha (GTK) has emerged as a promising probiotic fermented beverage. Few studies have investigated its effect on human health, mainly focusing intestinal microbiota composition, and metabolomics. The present study is pioneer in investigating the of GTK consumption individuals with excess body weight. This randomized controlled trial, lasting ten weeks, two groups placed under an energy-restricted diet: control (CG, n = 29), (KG, 30; 200 mL/d). Biological samples questionnaires were collected before after intervention. Microbiota analysis used amplification V4 region 16S rRNA. Serum untargeted metabolomics HPLC-TOF mass spectrometry. Intestinal permeability considered urine excretion lactulose mannitol, plasma zonulin, LPS-binding protein. After intervention, no differences related to found between groups, but only CG had increased fecal pH, lactulose/mannitol ratio, zonulin. In addition this, KG reported lower gastrointestinal symptoms motility compared CG, discriminant metabolites (e.g., diethyl malonate) strictly KG. did not significantly improve gut permeability. However, ameliorated positively influenced serum metabolome, which may contribute enhancing metabolic health

Language: Английский

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