Heavy Metal and Trace Element Status and Dietary Determinants in Children with Phenylketonuria DOI Open Access
İzzet Erdal, Yılmaz Yıldız, Sıddıka Songül Yalçin

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3463 - 3463

Published: Oct. 12, 2024

Background/Objectives: Heavy metals are a group of and metalloids that have relatively high density. They can cause toxicity even at very low levels. Trace elements required by all living organisms to maintain their normal growth, metabolism, development. Oral intake is the main route exposure both heavy trace elements. Phenylketonuria (PKU) most common amino acid metabolic disorder, best known treatment for patients requiring phenylalanine (Phe)-restricted diet. The objective present study was evaluate plasma metal levels, sources exposure, changes in these levels according dietary regimen, element correlations with PKU patients. Methods: conducted between July 2022 January 2024 on 105 aged 2–6 years diagnosed PKU. Results: percentage Pb individuals upper quartile increased 3.47 times (95% CI = 1.07–11.29) those who consumed canned foods 7.29 1.21–44.03) spring water. As tertile factor 7.26 2.09–25.28) under four age 8.17 2.13–31.27) food users. odds having blood Cd were 0.09 0.01–0.96) being breastfed 6–11 months compared 0–5 months. Zn lower (93.0 vs. 83.6 µg/dL, p 0.008) Phe-restricted Conclusions: did not find relationship status Our findings indicate consumption significant contributing Furthermore, our revealed age, perception economic level, breastfeeding, kitchen equipment, water usage certain metals.

Language: Английский

Heavy Metal and Trace Element Status and Dietary Determinants in Children with Phenylketonuria DOI Open Access
İzzet Erdal, Yılmaz Yıldız, Sıddıka Songül Yalçin

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3463 - 3463

Published: Oct. 12, 2024

Background/Objectives: Heavy metals are a group of and metalloids that have relatively high density. They can cause toxicity even at very low levels. Trace elements required by all living organisms to maintain their normal growth, metabolism, development. Oral intake is the main route exposure both heavy trace elements. Phenylketonuria (PKU) most common amino acid metabolic disorder, best known treatment for patients requiring phenylalanine (Phe)-restricted diet. The objective present study was evaluate plasma metal levels, sources exposure, changes in these levels according dietary regimen, element correlations with PKU patients. Methods: conducted between July 2022 January 2024 on 105 aged 2–6 years diagnosed PKU. Results: percentage Pb individuals upper quartile increased 3.47 times (95% CI = 1.07–11.29) those who consumed canned foods 7.29 1.21–44.03) spring water. As tertile factor 7.26 2.09–25.28) under four age 8.17 2.13–31.27) food users. odds having blood Cd were 0.09 0.01–0.96) being breastfed 6–11 months compared 0–5 months. Zn lower (93.0 vs. 83.6 µg/dL, p 0.008) Phe-restricted Conclusions: did not find relationship status Our findings indicate consumption significant contributing Furthermore, our revealed age, perception economic level, breastfeeding, kitchen equipment, water usage certain metals.

Language: Английский

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