Dual regulatory effects of gut microbiota and their metabolites in rheumatoid arthritis: balancing pathogenic and protective mechanisms

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Rheumatoid arthritis is a chronic autoimmune disorder characterized by destructive, symmetric joint inflammation and synovitis, resulting in substantial disability that profoundly compromises patients' quality of life. Its pathogenesis encompasses complex interactions between genetic environmental factors. Recent advances bacterial DNA sequencing technologies have uncovered significant correlation the human gut microbiota composition rheumatoid progression. Growing clinical experimental evidence establishes gut-joint axis as crucial mediator pathogenesis. Comprehensive investigation microbial communities their metabolites' influence on mechanisms, coupled with elucidation microbiome's bidirectional regulatory effects disease development, not only deepens our understanding pathological processes but also theoretical framework for developing novel diagnostic biomarkers personalized therapeutic interventions to enhance patient outcomes.

Language: Английский

Investigating the Role of Gut Microbiota in the Pathogenesis and Progression of Rheumatoid Arthritis in a Collagen-Induced Arthritis Mouse Model

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(11), P. 5099 - 5099

Published: May 26, 2025

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder whose precise etiology remains unclear, though growing evidence implicates gut microbiota in its pathogenesis. This study aimed to investigate the role of onset and progression RA by employing fecal transplantation (FMT) collagen-induced (CIA) mouse model using DBA/1J Aire−/− strains. Mice received FMT from healthy donors, treatment-naïve patients, or treated patients relapse, followed assessment composition via 16S rRNA sequencing, severity scoring, histological evaluations, inflammatory markers. The findings revealed distinct clustering patterns post-FMT across experimental groups, highlighting strain-specific colonization effects. Notably, genera such as Bifidobacterium Paraprevotella correlated positively with mice, whereas Corynebacterium, Enterorhabdus, Odoribacter exhibited negative correlations, suggesting potential protective roles. Despite these microbial differences, minor variations scores, paw inflammation, inflammation were observed among groups. indicates that although alterations are associated pathogenesis, further investigation larger cohorts comprehensive sequencing approaches essential elucidate therapeutic microbiome modulation diseases.

Language: Английский

Preclinical RA: How to halt its progression

Best Practice & Research Clinical Rheumatology, Journal Year: 2024, Volume and Issue: unknown, P. 102030 - 102030

Published: Dec. 1, 2024

Language: Английский