Gut Prevotella copri abundance linked to elevated post-exercise inflammation DOI Creative Commons
David C. Nieman, Camila A. Sakaguchi, James C. Williams

et al.

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101039 - 101039

Published: April 1, 2025

This study aimed to examine the linkage between gut microbiome taxa and exercise-induced inflammation. Twenty-five cyclists provided 4 stool samples during a 10-week period cycled vigorously for 2.25 h at 67% maximal oxygen uptake (VO2max) in laboratory setting. Blood were collected pre- post-exercise, with additional 1.5 h-, 3 24 h-post-exercise. Primary outcomes included composition alpha diversity via whole genome shotgun (WGS) sequencing (averaged from samples) targeted panel of 75 plasma oxylipins. A total 5719 identified, 339 that present more than 20% used analysis. Alpha was calculated by evenness, Analysis Composition Microbiomes (ANCOM) differential abundance analysis performed using QIIME2. composite variable 8 pro-inflammatory oxylipins generated arachidonic acid (ARA) cytochrome P-450 (CYP). ARA-CYP significantly elevated least post-exercise (p < 0.001); they strongly positively related Prevotella copri (P. copri) (R2 = 0.676, p 0.001) negatively 0.771, 0.001). revealed first time novel, positive relationship P. These data demonstrate about two-thirds wide variance inflammation following prolonged intensive exercise is largely explained single bacterial species: copri.

Language: Английский

Gut Prevotella copri abundance linked to elevated post-exercise inflammation DOI Creative Commons
David C. Nieman, Camila A. Sakaguchi, James C. Williams

et al.

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101039 - 101039

Published: April 1, 2025

This study aimed to examine the linkage between gut microbiome taxa and exercise-induced inflammation. Twenty-five cyclists provided 4 stool samples during a 10-week period cycled vigorously for 2.25 h at 67% maximal oxygen uptake (VO2max) in laboratory setting. Blood were collected pre- post-exercise, with additional 1.5 h-, 3 24 h-post-exercise. Primary outcomes included composition alpha diversity via whole genome shotgun (WGS) sequencing (averaged from samples) targeted panel of 75 plasma oxylipins. A total 5719 identified, 339 that present more than 20% used analysis. Alpha was calculated by evenness, Analysis Composition Microbiomes (ANCOM) differential abundance analysis performed using QIIME2. composite variable 8 pro-inflammatory oxylipins generated arachidonic acid (ARA) cytochrome P-450 (CYP). ARA-CYP significantly elevated least post-exercise (p < 0.001); they strongly positively related Prevotella copri (P. copri) (R2 = 0.676, p 0.001) negatively 0.771, 0.001). revealed first time novel, positive relationship P. These data demonstrate about two-thirds wide variance inflammation following prolonged intensive exercise is largely explained single bacterial species: copri.

Language: Английский

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