Association between bone mineral density T-score and respiratory sarcopenia in older adults

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 4, 2025

Introduction Respiratory sarcopenia, characterized by reduced respiratory muscle mass and strength, is underdiagnosed in older adults. This cross-sectional study aimed to investigate the association between bone mineral density (BMD) T-score sarcopenia a Chinese population. Methods A total of 530 participants aged ≥60 years were recruited. was diagnosed based on peak expiratory flow rate (PEFR) cutoffs. BMD measured using dual-energy X-ray absorptiometry, assessed bioelectrical impedance analysis. Logistic regression models used analyze risk. Results Participants with exhibited lower T-score, appendicular skeletal index, trunk ratio, lung function parameters compared those without sarcopenia. The odds ratio (95% CI) for lowest tertile risk 4.52 (1.71–13.1) highest tertile. remained significant after adjusting confounding factors. Conclusion significantly associated an increased finding highlights importance monitoring early prevention strategies reduce incidence

Language: Английский

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A Prospective Controlled Study on the Longitudinal Effects of Rehabilitation in Older Women with Primary Sarcopenia

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 609 - 609

Published: April 6, 2025

Sarcopenia, defined as a progressive loss of skeletal muscle mass, strength, and function, is leading contributor to disability, dependence, reduced quality life (HRQoL) in older adults. This study aimed evaluate the impact personalized six-month rehabilitation program, centered on tailored kinetic therapy, physical performance HRQoL women with primary sarcopenia. Methods: prospective controlled included 80 aged ≥65 years, allocated into Study Group (SG, n = 40), who followed supervised control group (CG, received general advice regarding activity nutrition. Physical was measured using short battery (SPPB), while assessed disease-specific SarQoL questionnaire. Evaluations were conducted at baseline after six months. Results: At baseline, both groups had comparable scores (SPPB: SG 5.75 ± 0.86 vs. CG 5.8 0.88, p 0.798; SarQoL: 54.42 8.76 55.59 4.61, 0.457). After months, showed significant improvements (SPPB 8.05 0.90, < 0.001; 62.55 7.00, 0.001). Significant gains observed domains related mental health, locomotion, functionality, leisure activities (p 0.05). In contrast, only minor, non-significant changes 6.17 0.78; 56.51 5.51). Conclusions: A structured, program significantly improves These results support need for individualized, programs optimizing functional recovery enhancing patient-centered outcomes sarcopenia management.

Language: Английский

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Sarcopenia in Chronic Kidney Disease: A Narrative Review from Pathophysiology to Therapeutic Approaches

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 352 - 352

Published: Feb. 4, 2025

Chronic kidney disease (CKD) is a progressive condition linked to sarcopenia, syndrome characterized by loss of skeletal muscle mass and strength, affecting quarter CKD patients globally. Sarcopenia has multiple paths through which it can worsen morbidity mortality as well decrease the quality life in CKD, including systemic inflammation, hormonal imbalances, metabolic changes, dysbiosis gut microbiota. There regional variation criteria set for diagnosis, with two main groups being European Working Group on Older People Asian Sarcopenia. Management regimes such nutritional optimization, vitamin D, exercise, correction acidosis, modulation microbiota constitute effective intervention strategies. Emerging therapeutic options include anabolic agents, myostatin inhibitors, anti-inflammatory treatment options. Future advances genomics, proteomics, personalized medicine will open up new avenues addressing complex pathophysiology sarcopenia. Hence, comprehensive multidisciplinary approach focused specific needs each patient be vital reducing effects sarcopenia improving situation people CKD.

Language: Английский

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Exercise effects on intrinsic capacity in acutely hospitalised older adults: a pooled analysis of two randomised controlled trials

Age and Ageing, Journal Year: 2025, Volume and Issue: 54(4)

Published: March 23, 2025

Hospitalisation often results in adverse effects older adults, particularly an increased risk of functional and cognitive decline. Although in-hospital exercise interventions have shown benefits, their impact on intrinsic capacity (IC) remains unknown. To assess the multicomponent training IC acutely hospitalised adults. Pooled analysis two randomised clinical trials. Three Acute Care for Elders units. Hospitalised adults (≥75 years). The control group received standard care, whereas participated program. primary outcome was assessed using a composite score (0-100) across five domains: vitality (handgrip strength), cognition (Mini-Mental State Examination), psychological health (Yesavage Geriatric Depression Scale), locomotion (Short Physical Performance Battery) sensory function (self-reported vision hearing). Adverse outcomes were evaluated 1 year after discharge, including emergency visits, hospital re-admission mortality. A total 570 patients (age 87.3 ± 4.8 years) enrolled during acute hospitalisation [median duration 8 (interquartile range = 3) days] to (n 288) or 282). intervention significantly improved compared [7.74 points, 95% confidence interval (CI) 6.45-9.03, P < .001], with benefits observed all domains. at discharge inversely associated mortality follow-up (OR 0.98 per each increase CI 0.96, 0.99, .010), although no association found visits (P .866) re-admissions .567). In-hospital is effective strategy enhance Additionally, related within discharge.

Language: Английский

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Molecular and metabolic effects of chronic stress on health, aging and carcinogenesis

Biopolymers and Cell, Journal Year: 2025, Volume and Issue: 41(1), P. 23 - 31

Published: April 14, 2025

Language: Английский

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Systematic Review of Sarcopenia Biomarkers in Hip Fracture Patients as a Potential Tool in Clinical Evaluation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13433 - 13433

Published: Dec. 15, 2024

Hip fractures are associated with high morbidity and mortality. Sarcopenia is a significant factor contributing to poor prognosis; however, the clinical diagnosis of sarcopenia remains difficult in surgical patients. This systematic review aims identify biomarkers as diagnostic predictive tools patients admitted for hip fracture surgery. A search was conducted MEDLINE, EMBASE, Google Scholar databases according PRISMA guidelines. Biomarker study quality assessed using BIOCROSS score. total 7 studies met inclusion criteria 515 were included, whom 402 (78%) female 113 (22%) male. The mean age participants 83.1 years (SD: 5.9). Skeletal muscle biopsies used biomarker assessment 14% (1/7) venous blood samples remaining 86% (6/7). highlighted included low expression insulin-like growth (IGF-I) tumor necrosis factor-α (TNF-α), along serum myostatin vitamin D levels. Overall, score satisfactory, all obtaining at least 13/20. orthopedic literature limited; this could be adjuncts

Language: Английский

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