Detection and quantification of miRNA 148a expression in infant formulas

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(1)

Published: Jan. 1, 2025

Abstract MiRNA 148a, which is associated with various biological processes such as immunity and cell differentiation, one of the most abundant miRNAs in breast milk. This study aimed to determine amount miRNA 148a different infant formulas, are used for infants who cannot receive The analyzed 20 including stage formulas (0–6 months age), two follow‐up (6–12 three toddler (above 12 premature ones, analyzing expression qPCR gene expression, significance set at p < 0.05. levels were compared, no statistically significant difference was observed ( > 0.05). Also, there relative across without probiotics Protein probiotic (0 month–1 year+) positively correlated = 0.022). Although has been shown be present it revealed that low compared milk line literature. In this direction, important increase current data on mechanisms action efforts ensure reach a composition closest their effects. Practical Application found exosomal compounds human very diverse terms number health effects, can control cells, immunity, apoptosis. One these For reason, study, content commonly healthy babies enough (breastfeeding recommended least 6 up 2 years) valid analyzed. conclusion, detected but level.

Language: Английский

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Bioactive compounds in human milk

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.

Language: Английский

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Sharing Milk and Knowledge in the Neonatal Intensive Care Unit Improves Care for Neonates in a Low- and Middle-Income Population—A North–South Collaboration

Children, Journal Year: 2025, Volume and Issue: 12(3), P. 326 - 326

Published: March 4, 2025

Background: Basic healthcare may significantly decrease neonatal morbidity and mortality. Attention to this, particularly in populations where rates of potentially preventable illness death within the first weeks life are extremely high, will have a positive impact on global health. Objective: This manuscript presents development quality improvement programme reduce evidence–practice gap care for neonates admitted NICU public hospital India. The was locally customised optimal sustainable results. Method: backbone project educational exchange nurses physicians between Norway Areas potential were mainly identified by clinicians focus areas subject dynamic changes over time. In addition, service centre lactation counselling milk banking established. Progress timeframe 2017–2019 compared with baseline data. Results: has shown that after collaborative effort, there is significant reduction mortality from 11% year 2016 5.5% 2019. reduced, as illustrated proportion culture-proven sepsis. Nutrition improved consumption human NICU-admitted remarkably increasing one third more than three forth their total intake, weight gain subgroup increase. With introduction family participatory care, hours skin-to-skin contact increased. Additional indicators also observed. Conclusions: It feasible low- middle-income hospitalised population improving basic including nutrition relatively inexpensively when utilising resources.

Language: Английский

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Protective effects of human breast milk-derived exosomes on inflammatory bowel disease through modulation of immune cells

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 20, 2025

Human breast milk (HBM)-derived exosomes play a crucial role not only in infant nutrition but also modulating inflammation, immunity, and epithelial cell protection. This study investigated how HBM-derived regulate immune development function. The promoted the differentiation of naïve CD4+ T cells into Treg Th2 while suppressing their Th17 Th1 cells. They enhanced proliferation intestinal Caco-2 reduced apoptosis dextran sulfate sodium (DSS)-damaged caco-2 In DSS-induced colitis mouse model, significantly alleviated disease severity, as evidenced by improvements colon length, activity index, histology grades. Furthermore, normalized subsets spleen, mesenteric lymph nodes, colon, restoring levels comparable to controls. These findings suggest that hold promise potential therapeutic strategy for inflammatory bowel T-cell responses protecting

Language: Английский

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Exosomes in Breast Milk: Their Impact on the Intestinal Microbiota of the Newborn and Therapeutic Perspectives for High-Risk Neonates

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3421 - 3421

Published: April 5, 2025

Breast milk exosomes are essential for the nutrition and immune development of newborn. These 30-150 nm extracellular vesicles contain microRNAs (miRNAs), mesessenger RNAS (mRNA)s, proteins lipids that facilitate cellular communication modulate neonatal system. In this article, we analyse impact breast on intestinal microbiota newborn, especially in high-risk neonates such as preterm infants or at risk necrotising enterocolitis (NEC). Exosomes promote colonisation beneficial bacteria Bifidobacterium Lactobacillus strengthen barrier. They also regulate response, balancing defence against pathogens tolerance to non-pathogenic antigens. This effect is key infants, who benefit from their anti-inflammatory preventive properties complications NEC. Research points potential therapeutic uses care, opening up new opportunities improve health vulnerable newborns through protective effects exosomes.

Language: Английский

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Therapeutic potential of human breast milk-derived exosomes in necrotizing enterocolitis

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 19, 2024

Language: Английский

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