Morroniside Ameliorates High-Fat and High-Fructose-Driven Chronic Kidney Disease by Motivating AMPK–TFEB Signal Activation to Accelerate Lipophagy and Inhibiting Inflammatory Response DOI
Cong Zhang,

Yuquan Xiong,

Yao-Hua Luo

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Studies have substantiated that dietary-fat- and fructose-overconsumption-caused lipid metabolism disorders can trigger renal lipotoxicity to drive the progression of chronic kidney disease (CKD). This study was conducted evaluate efficacy morroniside, a natural active substance extracted from fruit Cornus officinalis, in inhibiting CKD high-fat high-fructose-fed mice. Our results showed histological changes such as fatty degeneration tubular cells, dilatation, glomerular fibrosis, abnormal function kidneys high-fat- mice, which significantly improved after morroniside treatment. Mechanistically, maintained homeostasis inhibited NLRP3 inflammatory vesicle activation by activating AMPKα promote TFEB nuclear translocation-mediated lipophagy. Consistent were observed palmitic acid-induced HK-2 cells. Notably, silencing or both reversed effects promoting lipophagy responses vivo vitro. Therefore, our provides compelling evidence delays AMPK/TFEB-mediated inflammasome activation, suggesting dietary supplementation with morroniside-rich foods (such officinalis) might be an effective strategy for prevention CKD.

Language: Английский

Morroniside Ameliorates High-Fat and High-Fructose-Driven Chronic Kidney Disease by Motivating AMPK–TFEB Signal Activation to Accelerate Lipophagy and Inhibiting Inflammatory Response DOI
Cong Zhang,

Yuquan Xiong,

Yao-Hua Luo

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Studies have substantiated that dietary-fat- and fructose-overconsumption-caused lipid metabolism disorders can trigger renal lipotoxicity to drive the progression of chronic kidney disease (CKD). This study was conducted evaluate efficacy morroniside, a natural active substance extracted from fruit Cornus officinalis, in inhibiting CKD high-fat high-fructose-fed mice. Our results showed histological changes such as fatty degeneration tubular cells, dilatation, glomerular fibrosis, abnormal function kidneys high-fat- mice, which significantly improved after morroniside treatment. Mechanistically, maintained homeostasis inhibited NLRP3 inflammatory vesicle activation by activating AMPKα promote TFEB nuclear translocation-mediated lipophagy. Consistent were observed palmitic acid-induced HK-2 cells. Notably, silencing or both reversed effects promoting lipophagy responses vivo vitro. Therefore, our provides compelling evidence delays AMPK/TFEB-mediated inflammasome activation, suggesting dietary supplementation with morroniside-rich foods (such officinalis) might be an effective strategy for prevention CKD.

Language: Английский

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