Vascular Cognitive Impairment—The Molecular Basis and Potential Influence of the Gut Microbiota on the Pathological Process DOI Creative Commons
Piotr Olejnik, Aleksandra Golenia

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1962 - 1962

Published: Nov. 27, 2024

Cognitive impairment is a major healthcare challenge worldwide, with vascular cognitive (VCI) being its second leading cause after Alzheimer’s disease. VCI heterogeneous group of disorders resulting from various pathologies. Therefore, it particularly difficult to determine underlying and exact molecular basis. Nevertheless, the current understanding pathophysiological processes has changed evolved in last decades. The aim this narrative review summarize state knowledge on pathogenesis analyze potential role gut microbiota process, considering most recent scientific reports accordance these processes. Chronic cerebral hypoperfusion, which results impaired blood supply, i.e., oxygen nutrient deficiency, main mechanism VCI. Furthermore, chronic hypoperfusion triggers cascade changes, starting an energy imbalance, glutamate excitotoxicity, acidotoxicity, oxidative stress. Also, all above provoke activation microglia release pro-inflammatory cytokines that recruit systemic immune cells lead their infiltration into central nervous system, neuroinflammation. Blood–brain barrier dysfunction may occur at stages ultimately increasing permeability allowing potentially toxic substances enter brain parenchyma. Gut metabolites, have been identified numerous inflammatory conditions, also influence

Language: Английский

UPFs and Shortened Lifespans: Ultra-Processed Foods Linked to Accelerated Biological Aging; Consequences Across Human Body Systems and Implications for Associated Medical Specialties DOI Creative Commons
Nicholas A Kerna, Chibuike Eze, Okatta A. Ugochukwu

et al.

Scientia. Technology, science and society., Journal Year: 2025, Volume and Issue: 2(3), P. 13 - 36

Published: March 1, 2025

Ultra-processed foods (UPFs) are defined by their high levels of refined carbohydrates, unhealthy fats, artificial additives, and preservatives. These contribute to biological aging through mechanisms such as chronic inflammation, oxidative stress, metabolic dysfunction. Inflammation, disruptions in insulin signaling key factors the development aging-related diseases, including cardiovascular disease, diabetes, neurodegenerative disorders. Specifically, advanced glycation end-products (AGEs) epigenetic modifications significantly acceleration disrupting cellular function, promoting tissue damage, driving disease development. UPF consumption is linked cancer, gastrointestinal disorders, obstetric gynecological conditions, a range adverse effects on various body systems. Reducing intake encouraging healthier dietary patterns crucial for mitigating impact UPFs related health conditions. For individuals unable transition whole food-based diets, pharmaceutical medical interventions offer alternatives reduce UPF-related aging. A combined approach pharmacologic therapies adjustments may optimize outcomes, with ongoing research into novel treatments further enhancing strategies counteract effects. This review examines accelerating aging, which they associated potential mitigate

Language: Английский

Citations

0
The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition DOI Open Access

Martina Monaco,

Carola Torazza, Ernesto Fedele

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3015 - 3015

Published: March 26, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by cognitive decline, memory loss, and behavioural changes. While genetic predispositions pathological processes have been the traditional focus, this review highlights fundamental role of environmental factors, particularly nutrition, within exposome framework in modulating risk progression AD. The exposome, which includes totality exposures an individual's lifetime, provides comprehensive approach to understanding complex aetiology In review, we explore impact dietary factors cyclic nucleotide pathways (cAMP/cGMP) on AD, emphasizing potential interventions as therapeutic strategies. We investigate key aspects how nutrition affects accumulation β-amyloid, aggregation tau proteins, neuroinflammation. also examine specific nutrients performance Additionally, discuss nutraceuticals with anti-phosphodiesterase activity various animal models AD (such 5xFAD, 3xTg-AD, Tg2576, APP/PS1 mice) demonstrating effects onset progression.

Language: Английский

Citations

0
Correlation of cognitive impairment with Mediterranean diet and mortality: a prospective cohort study DOI Creative Commons
Ling Li, Xiaoxiao Zheng, Hongyue Ma

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 9, 2025

Long-term adherence to the Mediterranean Diet has been shown improve cognitive function in patients. However, there is a lack of evidence regarding impact diet and impairment on long-term mortality outcomes. This study aims explore whether an interaction between degree The included 2,520 participants from National Health Nutrition Examination Survey (NHANES) conducted 2011 2014. was assessed using 9-point alternative index (aMED index). Cognitive Consortium Establish Registry for Alzheimer's disease (CERAD), Animal Fluency Test (AFT), Digital Symbol Substitution (DSST). By accessing public records Death Index (NDI), NHANES participants' information linked death certificate determine causes during follow-up period, up December 31, 2019, with specified according ICD-10. Participants were categorized based median aMED score into low (scores 0-3), moderate (score 4), high 5-9) groups. by calculating arithmetic mean standardized scores (Z-scores) each test. below first quartile considered have impairment. Cox proportional hazards regression models used assess relationship impairment, aMED, all-cause cardiovascular Additionally, these outcomes evaluated. participants, 481 deaths which 129 (26.8%) cardiovascular-related. population 4, 632 individuals (25.1%) A higher associated reduced risk cardiovascular-related (HR, 0.65; 95% CI, 0.52-0.81, p < 0.001; HR, 0.73; 0.47-0.91, = 0.039). increased 1.78; 1.46-2.18, 1.80; 1.22-2.64, 0.003). Individuals both lower had risks mortality. Subgroup analysis indicates that only subgroup There increasing (p 0.028). concerning mortality, but not Among more significant

Language: Английский

Citations

0
Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer’s disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut–brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood–brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

Citations

0
Supporting Neurologic Health with Mushroom Nutrition DOI Open Access
Victoria Bell,

Plamen Dimitrov,

Tito Fernandes

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1568 - 1568

Published: May 2, 2025

Due to the extensive types of etiologies and risks causing over 600 mental health issues, convene adequate recommendations in primary care is a difficult assignment. The starting point for preventive interventions on neurologic disorders involves scrutinizing risk factors while targeting multiple hazards order increase success an early precautionary mediation plan action. factor most neurodegenerative diseases increasing worldwide median age, although one seven youngsters also experience disability, namely depression, representing decline well-being conferring considerable global public challenge. brain operates optimally when supported by holistic approach engaging several aspects, diet becoming integral part strategies. Treatment presently dominated pharmacotherapy, but additional strategies are needed prevent treat disorders. Dietary modification can prove be cost-effective strategy prevention and, certain conditions, treatment neurological Molecules dietary ingredients, micronutrients, phytonutrients, additives may modulate depression associated biomarkers. Nutritional exposure during developmental stages maternal impact, lifestyles, modulation gut microbiota through as novel therapies various neuropsychiatric conditions gaining interest maintaining health. Bioactive substances present different mushroom species have been ascribed both direct indirect mechanisms influence neurobehavior, here we support recognition nutrition influential element management some concerns. Scientific evidence demonstrating unequivocal link between nutritional mushrooms cognitive only beginning emerge, medicine should considered care.

Language: Английский

Citations

0
Vascular Cognitive Impairment—The Molecular Basis and Potential Influence of the Gut Microbiota on the Pathological Process DOI Creative Commons
Piotr Olejnik, Aleksandra Golenia

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1962 - 1962

Published: Nov. 27, 2024

Cognitive impairment is a major healthcare challenge worldwide, with vascular cognitive (VCI) being its second leading cause after Alzheimer’s disease. VCI heterogeneous group of disorders resulting from various pathologies. Therefore, it particularly difficult to determine underlying and exact molecular basis. Nevertheless, the current understanding pathophysiological processes has changed evolved in last decades. The aim this narrative review summarize state knowledge on pathogenesis analyze potential role gut microbiota process, considering most recent scientific reports accordance these processes. Chronic cerebral hypoperfusion, which results impaired blood supply, i.e., oxygen nutrient deficiency, main mechanism VCI. Furthermore, chronic hypoperfusion triggers cascade changes, starting an energy imbalance, glutamate excitotoxicity, acidotoxicity, oxidative stress. Also, all above provoke activation microglia release pro-inflammatory cytokines that recruit systemic immune cells lead their infiltration into central nervous system, neuroinflammation. Blood–brain barrier dysfunction may occur at stages ultimately increasing permeability allowing potentially toxic substances enter brain parenchyma. Gut metabolites, have been identified numerous inflammatory conditions, also influence

Language: Английский

Citations

2