Probiotics improve intestinal ischemia–reperfusion injury: a systematic review and meta-analysis DOI Creative Commons

Zicen Zhao,

Yuxuan Wu, Yufang Leng

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 22, 2025

Background Intestinal ischemia–reperfusion injury (IRI) is a common complication of intestinal surgery and carries the risk patient death. The treatment IRI an important direction current research. This study aimed to analyze animal experiments thus investigate effects probiotics administration on its mechanisms. Methods We included total 12 studies from 5 databases (PubMed, Web Science, Cochrane, Embase, Scopus), incorporating outcome metrics including Chiu’s score, levels malondialdehyde (MDA), myeloperoxidase (MPO) tumor necrosis factor-alpha (TNF- α ), IL-6, IL-1β, occludin, zonula occludens-1 (ZO-1), FITC-dextran bacteria (Lactobacillus, Bacteroides Bifidobacteria). Statistical analysis was performed using Review Manager 5.3. Results found that probiotic-added animals had less damage after compared controls, as evidenced by more intact barrier [occludin (2.83, 95% CI: 1.46 4.20, p < 0.0001), ZO-1 (3.30, 1.58 5.01, = 0.0002) (−3.83, −5.83 −2.29, 0.0001)], lower Chiu score (−1.83, −2.47 −1.20, fewer inflammatory factors [IL-6 (−2.19, −3.98 −0.39, 0.02), TNF- (−2.24, −4.15 −0.33, 0.02)], oxidative stress [MDA (−2.46, −4.62 −0.30, 0.03), MPO (−0.97, −1.77 −0.17; 0.02)]. In addition, probiotic supplementation increased relative abundance Lactobacillus (0.90, 0.33 1.48, 0.002) (0.81, 0.14 1.49, maintaining stability gut microbiota. Conclusion conclusion, mechanisms which therapy attenuates may be related decreased inflammation stress, abundance, expression tight junction (TJ) proteins. Systematic Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024577459 .

Language: Английский

Probiotics improve intestinal ischemia–reperfusion injury: a systematic review and meta-analysis DOI Creative Commons

Zicen Zhao,

Yuxuan Wu, Yufang Leng

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 22, 2025

Background Intestinal ischemia–reperfusion injury (IRI) is a common complication of intestinal surgery and carries the risk patient death. The treatment IRI an important direction current research. This study aimed to analyze animal experiments thus investigate effects probiotics administration on its mechanisms. Methods We included total 12 studies from 5 databases (PubMed, Web Science, Cochrane, Embase, Scopus), incorporating outcome metrics including Chiu’s score, levels malondialdehyde (MDA), myeloperoxidase (MPO) tumor necrosis factor-alpha (TNF- α ), IL-6, IL-1β, occludin, zonula occludens-1 (ZO-1), FITC-dextran bacteria (Lactobacillus, Bacteroides Bifidobacteria). Statistical analysis was performed using Review Manager 5.3. Results found that probiotic-added animals had less damage after compared controls, as evidenced by more intact barrier [occludin (2.83, 95% CI: 1.46 4.20, p < 0.0001), ZO-1 (3.30, 1.58 5.01, = 0.0002) (−3.83, −5.83 −2.29, 0.0001)], lower Chiu score (−1.83, −2.47 −1.20, fewer inflammatory factors [IL-6 (−2.19, −3.98 −0.39, 0.02), TNF- (−2.24, −4.15 −0.33, 0.02)], oxidative stress [MDA (−2.46, −4.62 −0.30, 0.03), MPO (−0.97, −1.77 −0.17; 0.02)]. In addition, probiotic supplementation increased relative abundance Lactobacillus (0.90, 0.33 1.48, 0.002) (0.81, 0.14 1.49, maintaining stability gut microbiota. Conclusion conclusion, mechanisms which therapy attenuates may be related decreased inflammation stress, abundance, expression tight junction (TJ) proteins. Systematic Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024577459 .

Language: Английский

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