Natural Antidiabetic Agents: Current Evidence and Development Pathways from Medicinal Plants to Clinical use
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(3)
Published: March 1, 2025
Diabetes
mellitus
is
a
long-term
metabolic
condition
marked
by
chronically
high
levels
of
glucose
in
the
blood
due
to
insufficient
synthesis
insulin
or
impaired
function.
Throughout
history,
several
civilizations
have
used
traditional
medicinal
plants
treat
and
control
diabetes.
This
paper
offers
thorough
review,
date,
antidiabetic
natural
compounds
origin,
specifically
highlighting
their
reported
modes
mechanisms
action
therapeutic
possibilities,
with
view
fast-tracking
possibility
transition
pharmaceutical
products
for
human
use.
Phytochemicals
such
as
flavonoids,
alkaloids,
terpenoids,
glycosides
notable
effects.
They
been
shown
via
many
processes,
including
boosting
secretion,
improving
sensitivity,
blocking
absorption
\gastrointestinal-tract,
regulating
carbohydrate
metabolism.
Unlike
earlier
reviews,
this
current
one,
addition
chemistry
proposed
action,
also
x-rays
effectiveness
safety
these
chemicals
combining
evidences
from
laboratory
research,
animal
experiments,
clinical
trials.
Several
substances,
Demethoxycurcumin,
Trigonelline,
Ginsenosides,
progressed
trials,
while
others
like
Allicin
Polypeptide-p
at
bedside.
Bisdemethoxycurcumin,
Vicine,
Gymnemosides,
are
now
preclinical
trial
phase,
suggesting
that
research
still
ongoing
there
promise
future
application.
The
review
highlights
evolution
diabetes
management,
potential
improve
treatment.
It
suggests
incorporating
plant-derived
into
treatments,
reducing
dependence
on
drugs
adverse
Language: Английский
Pharmacological Potential of Bioactive Compounds in Catharanthus roseus Extract: A Comprehensive Review
Keren Celestina Mendonce,
No information about this author
Naveen Palani,
No information about this author
Suriyaprakash Rajadesingu
No information about this author
et al.
Toxicology Reports,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101998 - 101998
Published: March 1, 2025
Language: Английский
Nutritional Value and Therapeutic Applications of Chenopodium album for Human and Livestock Health: A Comprehensive Review
Food Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106624 - 106624
Published: April 1, 2025
Language: Английский
GC–MS profiling and computational analysis of Balanites aegyptiaca phytoconstituents for antidiabetic activity: insights from network pharmacology and molecular docking
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 6, 2025
Language: Английский
Lipid-based nano-carriers for the delivery of anti-obesity natural compounds: advances in targeted delivery and precision therapeutics
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 7, 2025
Obesity
is
a
major
global
health
challenge,
contributing
to
metabolic
disorders
such
as
type
2
diabetes,
cardiovascular
diseases,
and
hypertension.
The
increasing
prevalence
of
obesity,
driven
by
sedentary
lifestyles,
poor
dietary
habits,
genetic
predisposition,
underscores
the
urgent
need
for
effective
therapeutic
strategies.
Conventional
pharmacological
treatments,
including
appetite
suppressants
modulators,
often
fail
provide
sustainable
weight
loss
due
side
effects,
adherence,
limited
long-term
efficacy.
As
result,
natural
bioactive
compounds
have
gained
attention
their
anti-obesity
potential.
However,
clinical
application
hindered
bioavailability,
rapid
metabolism,
inefficient
delivery.
Lipid-based
nano-carriers,
liposomes,
solid
lipid
nanoparticles,
nanostructured
carriers,
offer
promising
solution
enhancing
solubility,
stability,
targeted
delivery
these
compounds.
These
advanced
systems
improve
retention,
enable
controlled
release,
enhance
action
on
adipose
tissue
pathways.
Additionally,
functionalized
stimulus-responsive
nanocarriers
present
innovative
approaches
precision
obesity
treatment.
Despite
advancements,
challenges
remain
in
large-scale
production,
regulatory
approval,
safety.
Overcoming
barriers
critical
ensuring
successful
translation
nano-formulated
therapies.
This
review
explores
potential
lipid-based
nano-carriers
optimizing
efficacy
highlights
role
advancing
next-generation
management
Language: Английский