Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application DOI Creative Commons

Ziyuan Liang,

Lixian Deng,

Xiaoying Zhou

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 210 - 210

Published: Jan. 16, 2025

Reprogramming energy metabolism is pivotal to tumor development. Ketone bodies (KBs), which are generated during lipid metabolism, fundamental bioactive molecules that can be modulated satisfy the escalating metabolic needs of cancer cells. At present, a burgeoning body research concentrating on KBs within tumors, investigating their roles as signaling mediators, drivers post-translational modifications, and regulators inflammation oxidative stress. The ketogenic diet (KD) may enhance sensitivity various cancers standard therapies, such chemotherapy radiotherapy, by exploiting reprogrammed cells shifting state from glucose reliance KB utilization, rendering it promising candidate for adjunct therapy. Nonetheless, numerous questions remain regarding expression key genes across different regulation activities, impact individual types. Further investigation imperative resolve conflicting data concerning synthesis functionality tumors. This review aims encapsulate intricate in elucidating comprehensive grasp mechanisms highlighting emerging clinical applications, thereby setting stage future investigations into therapeutic potential.

Language: Английский

Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application DOI Creative Commons

Ziyuan Liang,

Lixian Deng,

Xiaoying Zhou

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 210 - 210

Published: Jan. 16, 2025

Reprogramming energy metabolism is pivotal to tumor development. Ketone bodies (KBs), which are generated during lipid metabolism, fundamental bioactive molecules that can be modulated satisfy the escalating metabolic needs of cancer cells. At present, a burgeoning body research concentrating on KBs within tumors, investigating their roles as signaling mediators, drivers post-translational modifications, and regulators inflammation oxidative stress. The ketogenic diet (KD) may enhance sensitivity various cancers standard therapies, such chemotherapy radiotherapy, by exploiting reprogrammed cells shifting state from glucose reliance KB utilization, rendering it promising candidate for adjunct therapy. Nonetheless, numerous questions remain regarding expression key genes across different regulation activities, impact individual types. Further investigation imperative resolve conflicting data concerning synthesis functionality tumors. This review aims encapsulate intricate in elucidating comprehensive grasp mechanisms highlighting emerging clinical applications, thereby setting stage future investigations into therapeutic potential.

Language: Английский

Citations

1