Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 466 - 466

Published: March 20, 2025

Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The microbiome interacts with the via a bidirectional relationship gut–liver axis. Microbial metabolites, sirtuins, responses pivotal in different metabolic diseases. This extensive review explores complex multifaceted interrelationship between sirtuins microbiota, highlighting their importance health disease, particularly hepatocellular carcinoma (HCC). Sirtuins (SIRTs), classified as group of NAD+-dependent deacetylases, serve crucial modulators wide spectrum cellular functions, including pathways, inflammatory response, process senescence. Their subcellular localization diverse functions link them various conditions, NAFLD cancer. Concurrently, comprising microorganisms, significantly influences host metabolism responses. Recent findings indicate modulate microbiota composition function, while can affect sirtuin activity. is relevant disorders, where dysbiosis contributes progression. highlights recent on roles specific maintaining implications HCC development. Understanding these interactions offers potential therapeutic avenues for managing diseases linked dysregulation pathology.

Language: Английский

Folic Acid Prevents High-Fat Diet-Induced Postpartum Weight Retention in Rats, Which Is Associated with a Reduction in Endoplasmic Reticulum Stress-Mediated Hepatic Lipogenesis

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4377 - 4377

Published: Dec. 19, 2024

Background: Proactively preventing postpartum weight retention (PPWR) is one of the effective intervention strategies to reduce occurrence obesity in women. Population studies have shown that serum folate levels are closely related body weight. The regulation folic acid on lipid metabolism has been fully confirmed both vivo and vitro studies. For many years, supplementation widely used periconceptional women due its role fetal neural tube defects. However, whether prior throughout pregnancy exerts preventive effects PPWR remains uncertain. This study aims investigate effect rats further explore underlying mechanisms. Methods: In this study, pregnant were administered dietary schedules: control diet (CON), high-fat (HF), combined with (FA) (HF + FA). Results: We discovered inhibited diet-induced elevations weight, visceral fat liver hepatic at 1 week post-weaning (PW). Western blot analysis showed expression endoplasmic reticulum (ER) stress-specific proteins including GRP78, PERK, eIF2α, IRE1α, XBP1 ATF6, subsequently decreasing synthesis SREBP-1c, ACC1 FAS. Conclusions: conclusion, rats, mechanism associated inhibition ER stress-mediated lipogenesis signaling pathways liver. Folic may serve as a potential strategy for PPWR. future, effectiveness prevention can be verified by population

Language: Английский