Fecal Short-Chain Fatty Acids Are Associated with Obesity in Gestational Diabetes
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 387 - 387
Published: Feb. 6, 2025
Background:
Short-chain
fatty
acids
(SCFAs),
which
are
produced
by
the
microbial
fermentation
of
undigested
carbohydrates,
play
an
important
role
in
metabolism
and
physiology
host.
SCFAs
involved
regulation
maternal
during
pregnancy
influence
weight
gain,
glucose
metabolism,
metabolic
hormones.
Methods:
In
2017,
women
who
were
treated
for
gestational
diabetes
mellitus
(GDM)
at
University
Medical
Centre
Ljubljana
invited
to
participate
a
longitudinal
study.
A
total
45
included
this
study
comprehensively
phenotyped.
During
second
third
trimester
pregnancy,
with
GDM
provided
fecal
samples
SCFA
analysis.
The
analyzed
high-performance
liquid
chromatography
simultaneous
determination
acetate,
propionate,
butyrate.
Results:
concentrations
feces
differed
between
overweight/obese
normal-weight
GDM.
Acetate
propionate
significantly
higher
pregnant
overweight
or
obese
before
compared
but
butyrate
not.
Butyrate
was
elevated
group
excessive
gain.
Conclusions:
relationship
obesity
is
complex,
association
remains
be
clarified.
Regardless
conflicting
publications
on
SCFAs,
our
showed
that
acetate
levels
associated
categories
Language: Английский
Trending Modalities in Type 2 Diabetes Prevention
The Journal of Clinical Endocrinology & Metabolism,
Journal Year:
2025,
Volume and Issue:
110(Supplement_2), P. S187 - S192
Published: Feb. 25, 2025
Prediabetes
now
affects
a
substantial
proportion
of
the
population,
marking
growing
group
individuals
at
increased
risk
for
development
type
2
diabetes
(T2D).
Given
profound
effect
T2D
on
an
individual's
morbidity
and
mortality,
prevention
is
critical
importance.
We
searched
PubMed
Ovid
MEDLINE
databases
recent
systematic
reviews,
meta-analyses,
original
research
articles
pertaining
to
prediabetes
T2D.
strategies
have
focused
intensive
lifestyle
modification
as
well
numerous
medications
that
ultimately
improve
insulin
resistance.
Recently,
better
understanding
gut
microbiome's
role
in
progression
has
suggested
possible
preventive
fecal
transplant.
Finally,
multiple
incretin
pharmaceutical
agents
been
developed
show
promise
treatment
The
number
novel
ways
prevent
rapidly
growing.
A
thorough
indications,
outcomes,
limitations
these
new
therapies
all
who
care
with
diabetes.
Language: Английский
Metabolic Regulation and Cardiorenal Protection: Deciphering the Potential and Multi-Target Mechanisms of Jiangtang Qingre Formula for Type 2 Diabetes Management
Published: Jan. 1, 2025
Language: Английский
Gut Microbiota and Metabolic Dysregulation in Elderly Diabetic Patients: Is There a Gender-Specific Effect
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(9), P. 3103 - 3103
Published: April 30, 2025
Background/Objectives:
The
aim
of
this
study
was
to
qualitatively
and
quantitatively
assess
the
bacterial
domain
gut
microbiome
in
elderly
patients
with
type
2
diabetes
(T2D),
a
focus
on
sex
differences,
glycemic
control,
lipid
disorders.
Methods:
This
included
60
older
adults
T2D
(38
women
22
men)
treated
metformin
or
combination
insulin.
microbiota
profiled
using
16S
rRNA
gene
sequencing.
Statistical
analyses,
including
correlation
analysis
multiple
regression,
were
performed
identify
associations
between
microbial
taxa,
sex,
metabolic
parameters.
Results:
No
statistically
significant
differences
alpha
beta
diversity
observed
sexes.
Multiple
regression
indicated
positive
relationship
Tenericutes
HbA1c
male
participants
(β
=
2.22931,
CI
[0.75,
3.70],
R
0.67;
R2
0.36;
unadjusted
p
0.0052;
adjusted
0.0496).
In
female
participants,
G0′
−2.24107,
[−3.19,
−1.30],
0.78;
0.58;
0.00003;
0.0005)
−1.86670,
[−2.61,
−1.12],
0.00001;
0.0003)
correlated
negatively
Verrucomicrobia
as
well
−1.90427,
[−2.95,
−0.85],
0.46;
0.17;
0.0008;
0.007)
−1.69561,
[−2.52,
−0.87],
0.0002;
0.002)
OD1
bacteria,
known
Parcubacteria.
Conclusions:
population
diabetes,
biological
did
not
significantly
affect
diversity.
However,
several
exploratory
taxa
parameters
differed
men
women,
suggesting
that
may
influence
specific
aspects
microbiota—metabolism
interactions.
These
preliminary
findings
underscore
importance
considering
both
age-
sex-related
factors
when
investigating
context
diabetes.
Language: Английский
The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4359 - 4359
Published: Dec. 18, 2024
Traumatic
brain
injury
(TBI)
represents
a
multifaceted
pathological
condition
resulting
from
external
forces
that
disrupt
neuronal
integrity
and
function.
This
narrative
review
explores
the
intricate
relationship
between
dietary
macronutrients,
gut
microbiota
(GM),
neuroinflammation
in
TBI.
We
delineate
dual
aspects
of
TBI:
immediate
mechanical
damage
(primary
injury)
subsequent
biological
processes
(secondary
exacerbate
damage.
Dysregulation
gut–brain
axis
emerges
as
critical
factor
neuroinflammatory
response,
emphasizing
role
GM
mediating
immune
responses.
Recent
evidence
indicates
specific
including
lipids,
proteins,
probiotics,
can
influence
composition
turn
modulate
neuroinflammation.
Moreover,
specialized
interventions
may
promote
resilience
against
secondary
insults
support
neurological
recovery
post-TBI.
aims
to
synthesize
current
preclinical
clinical
on
potential
strategies
mitigating
pathways,
suggesting
targeted
nutrition
health
optimization
could
serve
promising
therapeutic
modalities
TBI
management.
Language: Английский