Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Childhood obesity has emerged as a significant public health challenge, with profound consequences that negatively impact endocrine functions. Excess adiposity in children leads to dysregulation of various hormonal pathways, notably insulin resistance and hyperinsulinemia, the best-established changes obesity. If is not adequately managed, it might precipitate type 2 diabetes. Another common finding among thyroid dysfunction. Some studies suggest may be associated alterations hormone levels, potentially leading hypothyroidism, although relationship complex fully understood. Additionally, affects hypothalamic-pituitary-gonadal axis, resulting precocious puberty, particularly girls. Elevated leptin produced by adipose tissue, can contribute paradoxical state resistance, further complicating metabolic processes appetite regulation. Moreover, childhood result increased secretion cortisol, which enhance risk developing syndrome cardiovascular complications. The interplay between function also extends growth patterns, where excess weight lead acceleration followed potential short stature adulthood due early epiphyseal closure. Addressing requires comprehensive approach includes prevention, intervention, management strategies tailored this vulnerable population. Understanding these interactions crucial for effective policies mitigate on children. By reviewing research, work provides overview most relevant

Language: Английский