A nutrient wide association study of cardiovascular disease prevalence in older adults from NHANES 2007 to 2018 DOI Creative Commons
Wen Li, Siqi Liu, Xiaojun Meng

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 13, 2025

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, particularly among older adults. Identifying modifiable dietary factors associated with CVD prevalence is essential for prevention. This cross-sectional study analyzed 7,341 adults aged ≥ 65 years from NHANES 2007-2018. was defined based on self-reported physician-diagnosed conditions, including coronary heart disease, failure, angina, attack, or stroke. A nutrient-wide association (NWAS) evaluated associations between 56 nutrients and using multivariable logistic regression. Dose-response relationships were assessed restricted cubic spline (RCS) models. Model discrimination receiver operating characteristic (ROC) analysis. Eight significantly after adjusting confounders correcting multiple comparisons: PUFAs 20:4 (OR 0.88, 95% CI 0.80-0.97, P = 0.024), 22:5 0.72, 0.56-0.92, 0.019), 22:6 0.92, 0.87-0.99, 0.032); total choline 0.96, 0.93-0.99, 0.024); cholesterol 0.89, 0.82-0.96, 0.037); protein 0.82, 0.76-0.89, 0.040); vitamin 0.95, 0.91-0.99, 0.045); sugars 0.97, 0.96-0.98, 0.049). Clustering analysis identified protective effects fat-soluble vitamins unsaturated fatty acids. The inclusion these improved model (P < 0.05). key clusters characterized their dose-response relationships. Integrating into predictive models enhances risk discrimination, providing actionable targets prevention strategies in

Language: Английский

The impact of oleuropein, hydroxytyrosol, and tyrosol on cardiometabolic risk factors: a meta-analysis of randomized controlled trials DOI Creative Commons
Oleg Frumuzachi, Helena Kieserling, Sascha Rohn

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: Jan. 19, 2025

The so-called Mediterranean diet, with olive oil as a key component, is effective in reducing cardiometabolic disease risk. Olive consumption improves blood pressure, insulin levels and resistance, supporting heart health glycemic control. Its phenolic compounds, including oleuropein (OLE), hydroxytyrosol (HT), tyrosol (TYR) are hypothesized to likely contribute these benefits. Thus, this meta-analysis evaluated the clinical effects of dietary supplementation OLE, HT, TYR on outcomes. Fourteen human intervention studies 594 participants were included. analysis using random-effects model showed that significantly reduced total cholesterol (SMD = −0.19, CI: −0.37 −0.01, p 0.04, I2 35%), triacylglycerol −0.32, −0.60 −0.03, 0.03, 73%), −0.42, −0.82 78%). Subgroup that, certain contexts, interventions may be more beneficial for BMI <30, non-Mediterranean, individuals, while compound, type intervention, duration might have differential regarding considered Overall, suggests beneficially impact some parameters, though further needed confirm findings.

Language: Английский

Citations

0
A nutrient wide association study of cardiovascular disease prevalence in older adults from NHANES 2007 to 2018 DOI Creative Commons
Wen Li, Siqi Liu, Xiaojun Meng

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 13, 2025

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, particularly among older adults. Identifying modifiable dietary factors associated with CVD prevalence is essential for prevention. This cross-sectional study analyzed 7,341 adults aged ≥ 65 years from NHANES 2007-2018. was defined based on self-reported physician-diagnosed conditions, including coronary heart disease, failure, angina, attack, or stroke. A nutrient-wide association (NWAS) evaluated associations between 56 nutrients and using multivariable logistic regression. Dose-response relationships were assessed restricted cubic spline (RCS) models. Model discrimination receiver operating characteristic (ROC) analysis. Eight significantly after adjusting confounders correcting multiple comparisons: PUFAs 20:4 (OR 0.88, 95% CI 0.80-0.97, P = 0.024), 22:5 0.72, 0.56-0.92, 0.019), 22:6 0.92, 0.87-0.99, 0.032); total choline 0.96, 0.93-0.99, 0.024); cholesterol 0.89, 0.82-0.96, 0.037); protein 0.82, 0.76-0.89, 0.040); vitamin 0.95, 0.91-0.99, 0.045); sugars 0.97, 0.96-0.98, 0.049). Clustering analysis identified protective effects fat-soluble vitamins unsaturated fatty acids. The inclusion these improved model (P < 0.05). key clusters characterized their dose-response relationships. Integrating into predictive models enhances risk discrimination, providing actionable targets prevention strategies in

Language: Английский

Citations

0