The potential therapeutic approaches targeting gut health in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a narrative review DOI Creative Commons
Chou-Yi Hsu, Irfan Ahmad,

Ruth Maya

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 11, 2025

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disorder characterized by persistent fatigue and cognitive impairments, with emerging evidence highlighting the role of gut health in its pathophysiology. The main objective this review was to synthesize qualitative quantitative data from research examining microbiota composition, inflammatory markers, therapeutic outcomes interventions targeting microbiome context ME/CFS. collection involved detailed search peer-reviewed English literature January 1995 2025, focusing on studies related This comprehensive utilized databases such as PubMed, Scopus, Web Science, keywords including "ME/CFS," "Gut-Brain Axis," "Gut Health," "Intestinal Dysbiosis," "Microbiome "Pathophysiology," "Therapeutic Approaches." Where possible, insights clinical trials observational were included enrich findings. A narrative synthesis method also employed effectively organize present these study found notable changes diversity composition ME/CFS patients, contributing systemic inflammation worsening physical impairments. As result, various like probiotics, prebiotics, specific diets, supplements, fecal transplantation, pharmacological interventions, improved sleep, moderate exercise training are potential strategies that merit further exploration. Interventions gut-brain axis may help reduce neuropsychiatric symptoms utilizing benefits microbiome. Therefore, identifying beneficial elements incorporating their assessments into practice can enhance patient care through personalized treatments. Due complexity ME/CFS, which involves genetic, environmental, microbial factors, multidisciplinary approach necessary. Since current lacks how might aid treatment, standardized diagnostics longitudinal could foster innovative therapies, potentially improving quality life symptom management for those affected.

Language: Английский

The potential therapeutic approaches targeting gut health in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a narrative review DOI Creative Commons
Chou-Yi Hsu, Irfan Ahmad,

Ruth Maya

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 11, 2025

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disorder characterized by persistent fatigue and cognitive impairments, with emerging evidence highlighting the role of gut health in its pathophysiology. The main objective this review was to synthesize qualitative quantitative data from research examining microbiota composition, inflammatory markers, therapeutic outcomes interventions targeting microbiome context ME/CFS. collection involved detailed search peer-reviewed English literature January 1995 2025, focusing on studies related This comprehensive utilized databases such as PubMed, Scopus, Web Science, keywords including "ME/CFS," "Gut-Brain Axis," "Gut Health," "Intestinal Dysbiosis," "Microbiome "Pathophysiology," "Therapeutic Approaches." Where possible, insights clinical trials observational were included enrich findings. A narrative synthesis method also employed effectively organize present these study found notable changes diversity composition ME/CFS patients, contributing systemic inflammation worsening physical impairments. As result, various like probiotics, prebiotics, specific diets, supplements, fecal transplantation, pharmacological interventions, improved sleep, moderate exercise training are potential strategies that merit further exploration. Interventions gut-brain axis may help reduce neuropsychiatric symptoms utilizing benefits microbiome. Therefore, identifying beneficial elements incorporating their assessments into practice can enhance patient care through personalized treatments. Due complexity ME/CFS, which involves genetic, environmental, microbial factors, multidisciplinary approach necessary. Since current lacks how might aid treatment, standardized diagnostics longitudinal could foster innovative therapies, potentially improving quality life symptom management for those affected.

Language: Английский

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