Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography–Tandem Mass Spectrometry DOI Creative Commons

Panisara Suriyawongpongsa,

Sirirat Niyom,

Kannika Wanapinit

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(10), P. 1393 - 1393

Published: May 12, 2025

Cannabidiol (CBD), a non-psychotropic cannabinoid derived from Cannabis plants, is increasingly explored for its potential therapeutic applications in veterinary medicine. This study aimed to evaluate the impact of CBD oil on minimum alveolar concentration isoflurane (MACiso) cats. Sixteen healthy cats underwent anesthesia, and MACiso was determined using tail-clamping technique both at baseline 30 min after administration (2 mg/kg) via stomach tube. resulted significant 11% reduction MACiso, 1.77 ± 0.14% 1.62 0.21% (p < 0.001). Following administration, heart respiratory rates were elevated time determination compared whereas other physiological parameters remained unchanged. Serum biochemical analysis conducted two weeks post revealed decrease blood urea nitrogen (BUN) levels while one cat exhibited mild increase alanine aminotransferase (ALT). Proteomic identified 12 CBD-associated proteins feline serum with CBDA THCA synthases demonstrating upregulation. These findings indicate that reduces anesthetic requirements without inducing disturbances. Further research warranted elucidate underlying mechanisms CBD’s anesthetic-sparing effects implications anesthesia.

Language: Английский

Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography–Tandem Mass Spectrometry DOI Creative Commons

Panisara Suriyawongpongsa,

Sirirat Niyom,

Kannika Wanapinit

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(10), P. 1393 - 1393

Published: May 12, 2025

Cannabidiol (CBD), a non-psychotropic cannabinoid derived from Cannabis plants, is increasingly explored for its potential therapeutic applications in veterinary medicine. This study aimed to evaluate the impact of CBD oil on minimum alveolar concentration isoflurane (MACiso) cats. Sixteen healthy cats underwent anesthesia, and MACiso was determined using tail-clamping technique both at baseline 30 min after administration (2 mg/kg) via stomach tube. resulted significant 11% reduction MACiso, 1.77 ± 0.14% 1.62 0.21% (p < 0.001). Following administration, heart respiratory rates were elevated time determination compared whereas other physiological parameters remained unchanged. Serum biochemical analysis conducted two weeks post revealed decrease blood urea nitrogen (BUN) levels while one cat exhibited mild increase alanine aminotransferase (ALT). Proteomic identified 12 CBD-associated proteins feline serum with CBDA THCA synthases demonstrating upregulation. These findings indicate that reduces anesthetic requirements without inducing disturbances. Further research warranted elucidate underlying mechanisms CBD’s anesthetic-sparing effects implications anesthesia.

Language: Английский

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