Medical Science of Ukraine (MSU), Journal Year: 2025, Volume and Issue: 21(1), P. 71 - 76
Published: March 31, 2025
Aim: To assess the impact of vitamin D deficiency on fertility female rats and evaluate effectiveness its correction through D3 supplementation. Materials Methods. The study was conducted 41 Wistar albino rats. animals were divided into three groups: Group I (vitamin deficiency, n=16), II (deficiency + D3, n=15), control group (n=10). housing conditions complied with biological research standards. induce fed a special D-hypovitaminosis diet. determination 25(OH)D levels carried out at Department Vitamins Coenzymes Palladin Institute Biochemistry. Pregnancy confirmed by microscopic analysis vaginal smears. Statistical performed using MedStat v.5.2 EZR v.3.4.1 software. Shapiro-Wilk test used to check normal distribution, Student’s t-test applied compare groups. Results considered statistically significant p<0,05. Results. pregnancy rate lowest in (56,3%), while II, after supplementation, it increased 66,7%, compared 90% (p<0,05). highest conception confirms importance maintaining adequate for reproductive function. Although correcting improved indicators, did not reach observed group. Conclusion. Vitamin significantly reduces which may be associated hormonal imbalance ovulatory dysfunction. supplementation increases demonstrating positive effect correction. corrected values (90%), indicating need comprehensive approach normalizing levels.
Language: Английский