Effect of dietary selenium intake and hypertension on mild cognitive impairment in elderly (Preprint) DOI

Mengjie He,

Zhihong Wang, Yan Zou

et al.

Published: April 20, 2025

BACKGROUND It is urgent to achieve precise prevention for the mild cognitive impairment (MCI) population. OBJECTIVE This study aimed explore effects of dietary selenium intake and hypertension on MCI. METHODS A multicenter cross-sectional was conducted in 2020, involving 1084 elderly people aged ≥55 years Zhejiang Province, China. Data demographics, assessment, depression scale, physical examinations were collected. Dietary calculated based converted Food Frequency Questionnaire (FFQ) Composition Tables developed validated this data FFQ. Multivariate logistic regression models used assess relationship between interactive effect RESULTS The prevalence MCI among all participants 24.6%. After adjusting age, educational level, marriage, depression, BMI, central obesity, frequency social activities, sleep disturbances, smoking, drink alcohol, diabetes, energy salt seasonings intake, ≥ 100 g/d significantly associated with a reduced risk (OR = 0.27, 95% CI: 0.19~0.40), while an increased 1.82, 1.3~2.54). Subgroup analyses showed that stronger association found < μg/d 2.42, 1.40~4.17). Interaction analysis indicated had negative additive interaction (RERI: -1.389 (-2.574 ~ -0.205), AP: -3.165 (-5.739 -0.590), protective prevailed. CONCLUSIONS Selenium may have potential Precise intervention strategies are needed. CLINICALTRIAL None

Language: Английский

Effect of dietary selenium intake and hypertension on mild cognitive impairment in elderly (Preprint) DOI

Mengjie He,

Zhihong Wang, Yan Zou

et al.

Published: April 20, 2025

BACKGROUND It is urgent to achieve precise prevention for the mild cognitive impairment (MCI) population. OBJECTIVE This study aimed explore effects of dietary selenium intake and hypertension on MCI. METHODS A multicenter cross-sectional was conducted in 2020, involving 1084 elderly people aged ≥55 years Zhejiang Province, China. Data demographics, assessment, depression scale, physical examinations were collected. Dietary calculated based converted Food Frequency Questionnaire (FFQ) Composition Tables developed validated this data FFQ. Multivariate logistic regression models used assess relationship between interactive effect RESULTS The prevalence MCI among all participants 24.6%. After adjusting age, educational level, marriage, depression, BMI, central obesity, frequency social activities, sleep disturbances, smoking, drink alcohol, diabetes, energy salt seasonings intake, ≥ 100 g/d significantly associated with a reduced risk (OR = 0.27, 95% CI: 0.19~0.40), while an increased 1.82, 1.3~2.54). Subgroup analyses showed that stronger association found < μg/d 2.42, 1.40~4.17). Interaction analysis indicated had negative additive interaction (RERI: -1.389 (-2.574 ~ -0.205), AP: -3.165 (-5.739 -0.590), protective prevailed. CONCLUSIONS Selenium may have potential Precise intervention strategies are needed. CLINICALTRIAL None

Language: Английский

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