Chronic inflammation in obesity and neurodegenerative diseases: exploring the link in disease onset and progression
Molecular Biology Reports,
Journal Year:
2025,
Volume and Issue:
52(1)
Published: April 25, 2025
Language: Английский
Curcumin Modulation of the Gut–Brain Axis for Neuroinflammation and Metabolic Disorders Prevention and Treatment
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(9), P. 1430 - 1430
Published: April 24, 2025
Curcumin,
a
polyphenolic
compound
derived
from
Curcuma
longa,
has
gained
significant
attention
for
its
potential
therapeutic
benefits,
particularly
counteracting
inflammation,
oxidative
stress,
and
metabolic
disorders.
Its
chemical
structure,
featuring
conjugated
double
bonds
between
two
aromatic
rings,
allows
it
to
act
as
an
electron
donor,
thereby
mitigating
free
radical
formation.
Despite
poor
solubility
in
water,
curcumin
is
stable
acidic
environments
undergoes
metabolism
both
the
liver
gut.
Intestinal
microbiota,
at
colon
level,
further
metabolizes
into
several
derivatives,
including
dihydrocurcumin
tetrahydrocurcumin,
which
exhibit
antioxidant
anti-inflammatory
properties.
Studies
suggest
that
can
reduce
body
mass
index
(BMI)
improve
other
composition
parameters,
especially
when
used
combination
with
lifestyle
changes,
though
bioavailability
low
due
rapid
resulting
blood
concentration.
In
obesity,
dysfunctional
adipose
tissue
remodeling
chronic
inflammation
play
critical
roles
development
of
complications.
Curcumin’s
properties
are
related
inhibition
NF-κB
pathway,
leading
reduction
inflammatory
markers
adipocytes
macrophages.
Additionally,
modulates
stress
by
activating
NRF2
enhancing
cellular
defenses.
Emerging
evidence
also
supports
curcumin’s
improving
gut
health
modulating
microbiota
composition,
intestinal
barrier
function,
reducing
systemic
inflammation.
This
interaction
gut–brain
axis
highlights
broader
implications
neuroprotection,
positively
affects
cognitive
function
mitigates
neuroinflammation
neurodegenerative
diseases
like
Alzheimer’s.
disease.
Thus,
holds
promise
multifaceted
agent
management
obesity
associated
diseases.
Language: Английский
Bioactive molecules in wheat "Senatore Cappelli" food chain: Extraction, analysis, processing, and beneficial properties
Food and Chemical Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 115475 - 115475
Published: April 1, 2025
Ancient
grains,
once
forgotten
due
to
the
dominance
of
high-yield
modern
crops,
are
making
a
comeback
concerns
over
biodiversity
loss
and
global
food
challenges.
This
study
examines
nutritional
composition,
safety,
health
benefits
Senatore
Cappelli,
an
ancient
Italian
durum
wheat
variety
(SCW),
highlighting
its
potential
as
functional
food.
Using
multi-method
approach,
SCW
was
analyzed
across
four
chain
stages
(seeds,
flour,
pasta,
chaff)
for
compositional
changes,
phytochemical
content,
safety.
The
safety
raw
material
assessed
by
determination
biogenic
amines,
pesticides,
mycotoxins
pathogenic
microorganisms.
chemical
profile
detected
NMR
spectroscopy
revealed
presence
bioactive
molecules
such
phenolic
acids
carotenoids
in
case
chaff.
toxicity
ethanolic
extracts
evaluated
using
vitro
assays
on
murine
BV-2
microglial
cells
vivo
Caenorhabditis
elegans
animal
model.
No
cytotoxic
effects
were
at
concentrations
up
250
ng/mL
chaff
extract
1000
seed,
pasta
extracts.
Additionally,
extended
lifespan
C.
elegans,
indicating
anti-aging
health-promoting
properties.
These
results
position
valuable
resource
enhancing
compounds,
supporting
reintroduction
into
diets
use
development.
Language: Английский