Vitamin D and COVID-19: Clinical Evidence and Immunological Insights DOI Creative Commons
Olga Adriana Căliman-Sturdza,

Roxana Elena Gheorghita,

Iuliana Șoldănescu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 733 - 733

Published: April 30, 2025

Vitamin D has emerged as a potential modulator of immune responses, sparking interest in its role COVID-19 susceptibility and clinical outcomes. This review synthesizes current evidence explores immunological insights into the relationship between vitamin levels infection severity. Epidemiological studies indicate an inverse correlation deficiency increased risk severe disease, hospitalization, mortality patients. Immunologically, exerts regulatory effects on both innate adaptive immunity, enhancing antimicrobial defense mechanisms, reducing excessive inflammatory potentially mitigating cytokine storm events observed cases. Despite promising observational data, trials evaluating supplementation have shown mixed results, underscoring need for standardized dosing regimens patient stratification. Future research should focus large-scale randomized controlled to conclusively determine therapeutic optimal strategies managing COVID-19.

Language: Английский

Vitamin D and COVID-19: Clinical Evidence and Immunological Insights DOI Creative Commons
Olga Adriana Căliman-Sturdza,

Roxana Elena Gheorghita,

Iuliana Șoldănescu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 733 - 733

Published: April 30, 2025

Vitamin D has emerged as a potential modulator of immune responses, sparking interest in its role COVID-19 susceptibility and clinical outcomes. This review synthesizes current evidence explores immunological insights into the relationship between vitamin levels infection severity. Epidemiological studies indicate an inverse correlation deficiency increased risk severe disease, hospitalization, mortality patients. Immunologically, exerts regulatory effects on both innate adaptive immunity, enhancing antimicrobial defense mechanisms, reducing excessive inflammatory potentially mitigating cytokine storm events observed cases. Despite promising observational data, trials evaluating supplementation have shown mixed results, underscoring need for standardized dosing regimens patient stratification. Future research should focus large-scale randomized controlled to conclusively determine therapeutic optimal strategies managing COVID-19.

Language: Английский

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