Association of Polycystic Ovary Syndrome with Clinical, Physical, and Reproductive Factors: A Data-Driven Analysis
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(6), P. 711 - 711
Published: March 12, 2025
Background/Objectives:
Polycystic
Ovary
Syndrome
(PCOS)
is
a
multifactorial
endocrine
disorder
with
significant
clinical
and
reproductive
implications.
Identifying
dose–response
relationships
between
clinical,
physical,
factors
PCOS
can
enhance
diagnostic
accuracy
inform
treatment
strategies.
This
study
utilized
data-driven
approach
to
analyze
the
associations
key
factors,
including
age,
weight,
menstrual
cycle
length,
Anti-Mullerian
Hormone
(AMH)
levels,
follicle
count,
prevalence.
Methods:
A
retrospective
analysis
was
conducted
on
dataset
of
539
participants
determine
optimal
ranges
these
associated
an
increased
likelihood
diagnosis.
Statistical
analyses
were
using
Python,
correlation
matrix,
univariate
multivariate
logistic
regression,
evaluations.
Results:
Our
findings
demonstrated
that
risk
increases
positively
in
women
under
32
years
age.
AMH
levels
above
4.18
ng/mL
strongly
PCOS,
suggesting
higher
may
reflect
excessive
follicular
activity
rather
than
enhanced
ovarian
function.
Weight
correlated
emphasizing
role
metabolic
disturbances
its
pathophysiology.
Additionally,
length
exhibited
non-linear
association
both
shortened
prolonged
cycles
being
indicative
hormonal
dysregulation.
count
consistently
linked
reinforcing
significance.
Conclusions:
provides
evidence
factors.
The
proposed
serve
as
valuable
reference
points
for
clinicians,
aiding
early
diagnosis
personalized
management
strategies
PCOS.
Language: Английский
The Anti-Mullerian Hormone as a Biomarker of Effectiveness of Metformin Hydrochloride Therapy in Polycystic Ovarian Syndrome and Insulin Resistance
Healthcare,
Journal Year:
2025,
Volume and Issue:
13(8), P. 884 - 884
Published: April 11, 2025
Background/Objectives:
Among
the
therapeutic
options
available
for
managing
PCOS,
metformin
improves
insulin
sensitivity,
reduces
androgen
levels,
and
helps
restore
menstrual
regularity
ovulation.
While
primarily
used
its
metabolic
effects,
therapy
may
also
influence
reproductive
parameters,
including
AMH
which
are
pivotal
in
improving
ovarian
function
predicting
outcomes
PCOS.
The
aim
of
this
study
was
to
search
scientific
literature
analyze
correlation
between
levels
hydrochloride
women
with
PCOS
IR.
Methods:
A
systematic
review
conducted
using
following
keywords:
polycystic
syndrome,
anti-Mullerian
hormone,
resistance,
metformin,
treatment,
biomarker,
syndrome.
This
aimed
at
investigating
potential
as
a
biomarker
effectiveness
patients
Results:
Metformin
treatment
has
shown
significant
reductions
serum
prolonged
therapy.
As
an
sensitizer,
hyperinsulinemia,
suppresses
hyperandrogenism.
process
inhibits
growth
antral
follicles,
is
reflected
decreased
levels.
Conclusions:
Reductions
improvements
sensitivity
can
serve
indicators
efficacy
enhancements
these
patients.
could
be
considered
prognostic
marker
evaluating
decrease
indicate
improved
reduction
morphology.
However,
further
research
necessary
confirm
findings
determine
optimal
dosages
duration
treatment.
Language: Английский