The role of gut microbiota in modulating immune responses in chronic liver disease: a systematic review and meta-analysis DOI Creative Commons

Eyad Gadour,

Khalid Shrwani,

Zeinab Hassan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Introduction The gut microbiota plays a crucial role in regulating immune responses and maintaining balance within the gut-liver axis. In patients with chronic liver disease (CLD), alterations have been linked to progression impaired function. This study aimed evaluate impact of gut-modulating therapies on CLD. Method Two independent authors conducted comprehensive literature search using complementary strategies identify relevant articles published until March 2025. Review Manager Software (RevMan 5.4) was used for data analysis, results were presented forest plots. Results Of 373 identified studies, 16 included analysis. findings revealed that microbiota-modulating significantly reduced tumor necrosis factor-α (TNF-α) levels compared control interventions (standardized mean difference [SMD], -0.60; 95% confidence interval [CI] [-0.93, -0.23] p = 0.001), similar observed at 6-month follow-up (SMD -1.3; CI [-2.1, -0.4] 0.004). Interleukin-6 (IL-6) showed no significant change between groups (SMD, -0.67; [-1.5, 0.12) 0.09). C-reactive protein (CRP) by -1.057; [-1.493, -0.621] 0.0005), consistent 1- follow-up. Changes interferon-gamma (IFN-γ) IL-18 cellular immunity also assessed. Conclusion highlights importance modulating CLD demonstrates effectiveness long-term reducing inflammatory markers. While CRP TNF-α decreased, changes IL-6 inconsistent, warranting further research elucidate this biomarker.

Language: Английский

The Expanding Role of Probiotics in Human Health DOI Open Access
George Stavrou, Katerina Kotzampassi

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1116 - 1116

Published: March 24, 2025

Since the 1990s, it has been widely documented that probiotics, either alone or in combination with prebiotic supplements, play a vital role host health and disease management [...].

Language: Английский

Citations

0
The role of gut microbiota in modulating immune responses in chronic liver disease: a systematic review and meta-analysis DOI Creative Commons

Eyad Gadour,

Khalid Shrwani,

Zeinab Hassan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Introduction The gut microbiota plays a crucial role in regulating immune responses and maintaining balance within the gut-liver axis. In patients with chronic liver disease (CLD), alterations have been linked to progression impaired function. This study aimed evaluate impact of gut-modulating therapies on CLD. Method Two independent authors conducted comprehensive literature search using complementary strategies identify relevant articles published until March 2025. Review Manager Software (RevMan 5.4) was used for data analysis, results were presented forest plots. Results Of 373 identified studies, 16 included analysis. findings revealed that microbiota-modulating significantly reduced tumor necrosis factor-α (TNF-α) levels compared control interventions (standardized mean difference [SMD], -0.60; 95% confidence interval [CI] [-0.93, -0.23] p = 0.001), similar observed at 6-month follow-up (SMD -1.3; CI [-2.1, -0.4] 0.004). Interleukin-6 (IL-6) showed no significant change between groups (SMD, -0.67; [-1.5, 0.12) 0.09). C-reactive protein (CRP) by -1.057; [-1.493, -0.621] 0.0005), consistent 1- follow-up. Changes interferon-gamma (IFN-γ) IL-18 cellular immunity also assessed. Conclusion highlights importance modulating CLD demonstrates effectiveness long-term reducing inflammatory markers. While CRP TNF-α decreased, changes IL-6 inconsistent, warranting further research elucidate this biomarker.

Language: Английский

Citations

0