Assessing cross-national inequalities and predictive trends in gout burden: a global perspective (1990–2021)

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Background Gout, caused by hyperuricemia and the deposition of monosodium urate crystals in joints, remains a major global health issue. Despite progress treatment, its prevalence continues to rise, contributing comorbidities like cardiovascular chronic kidney diseases. Understanding trends sociodemographic disparities is crucial for developing targeted interventions. Methods We analyzed gout prevalence, incidence, disability-adjusted life years (DALYs) from 1990 2021, stratified age, sex, economic development. Decomposition analysis quantified impact demographic factors, while advanced assessed relationship between burden socioeconomic Prediction models forecasted future trends, cross-national inequalities were evaluated highlight across regions with different development levels. Results Between increased 22,264,515 (95% UI: 17,793,190–27,965,605) 56,474,572 45,161,987–70,288,316), age-standardized rate (ASPR) rising 536.54 653.82 per 100,000 population [(Estimated annual percentage changes) EAPC: 0.87%, 95% CI: 0.80–0.95]. The incidence cases 136.1%, (ASIR) 17.12% over this period. Similarly, death (ASDR) grew 21.30%, accompanied substantial increase DALYs. revealed that aging significantly contributed Middle SDI (36.79%), growth was dominant factor Low (98.58%). Advanced indicated gaps observed optimal levels high-SDI countries, such as United States Australia, highlighting unrealized opportunities improving outcomes. projected stable 2021 2045, notable gender-specific age-specific trends. Cross-national inequality showed worsening DALYs high- low-SDI regions, reflected increasing Slope Index Inequality Health Concentration values 2021. Conclusion has risen, facing risks lifestyle changes obesity, struggle healthcare access. Public strategies should focus on modifiable risk infrastructure, gender- address disparities.

Language: Английский

Metabolic Syndrome Prevention Potential of Tamarillo: Phytochemical Composition, Antioxidant Activity, and Enzyme Inhibition Before and After Digestion

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1282 - 1282

Published: April 7, 2025

Tamarillo (Solanum betaceum Cav.) is rich in polyphenols, anthocyanins, and carotenoids, making it a promising candidate for functional food development. This study investigated phytochemical profiles bioactivities different tamarillo parts. Various parts of were extracted using water ethanol (0-95%), with 95% yielding the highest content bioactive compounds peel, pulp, mucilage, whole fruit, while 75% was more effective seeds. Among components, peel exhibited concentrations hydroxycinnamoyl derivatives, along superior antioxidant capacity, including strong scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50, 45.26 µg extract/mL) high reducing power 113.3 extract/mL). The extract strongest inhibitory effects on α-glucosidase (IC50, 1.623 mg/mL) angiotensin-converting enzymes 1.435 mg/mL). In contrast, pulp demonstrated pancreatic lipase 0.882 α-amylase 2.369 These findings suggest that extracts possess potent enzyme-inhibitory properties related to metabolic syndrome (MetS). However, gastrointestinal digestion simulation influenced compound bioactivities. Overall, has potential as ingredient MetS prevention, but processing strategies are needed retain its properties.

Language: Английский

Plant-Based Foods for Chronic Skin Diseases: A Focus on the Mediterranean Diet

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 6, 2025

In this narrative review, we provide an overview of how adherence to a Mediterranean dietary pattern can complement traditional treatment strategies for psoriasis, acne, and hidradenitis suppurativa. We emphasize the importance integrated approach, with interventions as key component holistic patient care. Psoriasis, suppurativa are immune-mediated chronic diseases marked by systemic inflammation, genetic environmental factors influencing their onset. The diet, rich in plant-based foods antioxidant anti-inflammatory properties-such whole-grain cereals, extra-virgin olive oil, vegetables, legumes, fruits, nuts-has been shown reduce clinical severity these conditions. It also supports weight control positively impacts metabolic cardiovascular risk factors, which closely linked diseases. Dietary education, particularly about plays crucial role management skin serves important non-pharmacological option that influence prognosis. This review offers specific nutrition recommendations prescribing diet patients inflammatory

Language: Английский